All Outputs (9)

An investigation into the molecular mechanisms of hyperbaric oxygen using a human dermal microvascular endothelial cell line and a porcine retinal explant model. (2019)
Thesis
IWUAGWU, B.U. 2019. An investigation into the molecular mechanisms of hyperbaric oxygen using a human dermal microvascular endothelial cell line and a porcine retinal explant model. Robert Gordon University [online], PhD thesis. Available from: https://openair.rgu.ac.uk

Diabetes is a debilitating metabolic condition with associated vascular complications that are a major cause of morbidity and mortality. Endothelial dysfunction is central to microvascular complications such as diabetic retinopathy (DR) and impaired... Read More about An investigation into the molecular mechanisms of hyperbaric oxygen using a human dermal microvascular endothelial cell line and a porcine retinal explant model..

The effect of single nucleotide polymorphisms and metabolic substrates on the cellular distribution of mammalian BK channels. (2017)
Thesis
ADEYILEKA-TRACZ, B.A. 2017. The effect of single nucleotide polymorphisms and metabolic substrates on the cellular distribution of mammalian BK channels. Robert Gordon University, PhD thesis.

Humans are approximately 99% similar with inter-individual differences caused in part by single-nucleotide polymorphisms (SNPs), which poses a challenge for the effective treatment of disease. Bioinformatics resources can help to store and analyse ge... Read More about The effect of single nucleotide polymorphisms and metabolic substrates on the cellular distribution of mammalian BK channels..

Hypoxia-induced responses of porcine pulmonary veins. (2017)
Thesis
ARNOLD, A. 2017. Hypoxia-induced responses of porcine pulmonary veins. Robert Gordon University, PhD thesis.

The pulmonary vein (PV) constricts to hypoxia however little is known about the underlying mechanisms. Hypoxic PV constriction is proposed to recruit upstream capillary beds and optimise gas exchange in healthy humans and may play a role in high alti... Read More about Hypoxia-induced responses of porcine pulmonary veins..

Studies investigating the mechanisms of the cardioprotective effects of Cannabidiol. (2014)
Thesis
HEPBURN, C.Y. 2014. Studies investigating the mechanisms of the cardioprotective effects of Cannabidiol. Robert Gordon University, PhD thesis.

The phytocannabinoid cannabidiol (CBD) has a complex pharmacology which is thought to include, but is not limited to, an ability to act as an inverse agonist at the CB1 and CB2 receptors and an antagonist of GPR55. Moreover, is has been shown to redu... Read More about Studies investigating the mechanisms of the cardioprotective effects of Cannabidiol..

Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation. (2010)
Thesis
SKENE, K.E. 2010. Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation. Robert Gordon University, PhD thesis.

Neointimal formation is a complex process that occurs due to the over compensatory healing response produced by the vessel following injury. Three key events, SMC proliferation, SMC migration and the inflammatory response, occur in unison to drive th... Read More about Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation..

Cellular mechanisms of acute hypoxic pulmonary vasoconstriction in intrapulmonary veins. (2009)
Thesis
DOSPINESCU, C. 2009. Cellular mechanisms of acute hypoxic pulmonary vasoconstriction in intrapulmonary veins. Robert Gordon University, PhD thesis.

In the pulmonary circulation, alveolar hypoxia contributes to blood flow regulation. Hypoxic pulmonary vasoconstriction (HPV) involves both pulmonary arteries and veins, but little is known of the contractile mechanisms specific to the veins. The aim... Read More about Cellular mechanisms of acute hypoxic pulmonary vasoconstriction in intrapulmonary veins..

Investigation of hypoxia and hyperglycaemia mediated DNA damage in human endothelial cells. (2008)
Thesis
WEIDMANN, A.E. 2008. Investigation of hypoxia and hyperglycaemia mediated DNA damage in human endothelial cells. Robert Gordon University, PhD thesis.

Chronic complications of diabetes mellitus are a pathological consequence of unregulated levels of blood glucose leading to disorders of the vascular system. When investigating the vascular complications the changes in the endothelium are of particul... Read More about Investigation of hypoxia and hyperglycaemia mediated DNA damage in human endothelial cells..

Use of a three dimensional porcine retinal explant model to detect HIF1 alpha and targets for understanding diabetic retinopathy.
Presentation / Conference Contribution
IWUAGWU, B.U., CRUICKSHANK, S.F., ROWE, I. and KNOTT, R.M. 2017. Use of a three dimensional porcine retinal explant model to detect HIF1 alpha and targets for understanding diabetic retinopathy. Presented at the American Society for Biochemistry and Molecular Biology annual meeting 2017 (ASBMB'17), 22-26 April 2017, Chicago, USA.

Diabeticretinopathy (DR) is a major microvascular complication associated with diabetes mellitus and is a leading cause of blindness. Hypoxia and hyperglycemia are suggested to play crucial pathophysiological roles, but the exact mechanisms are compl... Read More about Use of a three dimensional porcine retinal explant model to detect HIF1 alpha and targets for understanding diabetic retinopathy..

Exploring the opinions of community pharmacists on the implementation of satellite methadone clinics in Malta: a small island state.
Presentation / Conference Contribution
TONNA, R., TONNA, A., MIFSUD, J. and CRUICKSHANK, S. 2020. Exploring the opinions of community pharmacists on the implementation of satellite methadone clinics in Malta: a small island state. Presented at the 2020 Health services research and pharmacy practice conference, 16-17 April 2020, Cardiff, UK.

Methadone maintenance treatment (MMT) was introduced in Malta in 1987 and is provided by the Substance Misuse Outpatient Unit (SMOPU), formerly referred to as Detox. Presently Malta’s national drug policy encourages healthcare professionals and servi... Read More about Exploring the opinions of community pharmacists on the implementation of satellite methadone clinics in Malta: a small island state..