Dr Janine Coombes is a lecturer in Biological Sciences in the School of Pharmacy, Applied Science and Public Health. She also serves as the Research Degrees Coordinator for the school, overseeing PGR progression.
Janine received her DPhil in Immunology from the University of Oxford. During this period, she uncovered novel mechanisms through which dendritic cells in the intestine drive regulatory T cell differentiation. This discovery provided a deeper understanding of how immune tolerance is maintained in the gut, preventing harmful inflammation.
After completing her DPhil, Janine was awarded a Wellcome Trust Postdoctoral Fellowship jointly held at the University of Oxford and The University of California, Berkeley. While at Cal, Janine used advanced imaging methods to better understand immune cell behaviour in complex tissues, particularly in the context of host-pathogen interactions.
After returning to the UK, Janine established her independent research group at the university of Liverpool in 2013, holding various positions from Wellcome Tenure Track Fellow to Senior Lecturer. There, her group worked on developing novel in vitro models of intestinal parasitic infections. She has been a co-investigator and principal investigator on numerous research projects funded by prestigious bodies such as the BBSRC and MRC, with grants totalling over £2 million.
In 2021, Janine moved to RGU. She continues to work on 3D cell culture models of the human intestine, with a view to better understanding how harmful inflammation is controlled in the intestine.
Research Interests
Mucosal immunology.
Intestinal organoid models.
Dendritic cells.
Developing animal-free models of the human intestine.
Creation of synthetic flow cytometry data sets for use in the class room.
Scopus Author ID
8873294100
PhD Supervision Availability
Yes
PhD Topics
Developing animal-free models of the human intestine.
Creation of synthetic flow cytometry data sets for use in the class room.
