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Understanding the beneficial and harmful effects of Tranexamic Acid to treat traumatic haemorrhage

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Project Description

Traumatic injury accounts for 4.9 million deaths worldwide each year. Approximately 25% of trauma patients die within 6 h of injury from uncontrolled bleeding, termed trauma induced coagulopathy (TIC). TIC describes the overall failure of the blood clotting system to stop bleeding after injury. TIC is associated with an increased need for transfusion therapy and a 3-4 fold increased risk of death. Major trauma costs the NHS £150 million per year, with transfusion therapies accounting for approximately 12% of this cost.

Tranexamic acid (TXA) is an anti-fibrinolytic drug given to prevent bleeding, however, there is a short window of time (3h post-injury) where it can be used safely. This project will investigate changes in key molecules of the blood clotting process over time to determine why TXA becomes harmful 3h post-injury.

Type of Project Research Grant
Status Project Live
Funder(s) Friends of Anchor
Value £12,348.00
Project Dates Oct 1, 2024 - Sep 30, 2025

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