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Theranostic approach for the protein corona of polysaccharide nanoparticles.

Skalickova, Sylvie; Horky, Pavel; Mlejnkova, Veronika; Skladanka, Jiri; Hosnedlova, Bozena; Ruttkay?Nedecky, Branislav; Fernandez, Carlos; Kizek, Rene


Sylvie Skalickova

Pavel Horky

Veronika Mlejnkova

Jiri Skladanka

Bozena Hosnedlova

Branislav Ruttkay?Nedecky

Rene Kizek


Polysaccharide nanoparticles are promising materials in the wide range of disciplines such as medicine, nutrition, food production, agriculture, material science and others. They excel- not only in their non-toxicity and biodegradability but also in their easy preparation. As well as inorganic particles, a protein corona (PC) around polysaccharide nanoparticles is formed in biofluids. Moreover, it has been considered that the overall response of the organism to nanoparticles presence depends on the PC. This review summarises scientific publications about the structural chemistry of polysaccharide nanoparticles and their impact on theranostic applications. Three strategies of implementation of the PC in theranostics have been discussed: I) Utilisation of the PC in therapy; II) How the composition of the PC is analysed for specific disease markers; III) How the formed PC can interact with the immune system and enhances the immunomodulation or immunoelimination. Thus, the findings from this review can contribute to improve the design of drug delivery systems. However, it is still necessary to elucidate the mechanisms of nano-bio interactions and discover new connections in nanoscale research.


SKALICKOVA, S., HORKY, P., MLEJNKOVA, V., SKLADANDA, J., HOSNEDLOVA, B., RUTTKAY-NEDECKY, B., FERNANDEZ, C. and KIZEK, R. 2021. Theranostic approach for the protein corona of polysaccharide nanoparticles. Chemical record [online], 21(1), pages 17-28. Available from:

Journal Article Type Article
Acceptance Date Oct 22, 2020
Online Publication Date Nov 16, 2020
Publication Date Jan 31, 2021
Deposit Date Dec 11, 2020
Publicly Available Date Nov 17, 2021
Journal Chemical Record
Print ISSN 1527-8999
Electronic ISSN 1528-0691
Publisher Wiley Open Access
Peer Reviewed Peer Reviewed
Volume 21
Issue 1
Pages 17-28
Keywords Chitosan; Diagnostics; Drug delivery; Immune response; Stealth strategy
Public URL