Theranostic approach for the protein corona of polysaccharide nanoparticles.

Skalickova, Sylvie; Horky, Pavel; Mlejnkova, Veronika; Skladanka, Jiri; Hosnedlova, Bozena; Ruttkay?Nedecky, Branislav; Fernandez, Carlos; Kizek, Rene

Abstract

Polysaccharide nanoparticles are promising materials in the wide range of disciplines such as medicine, nutrition, food production, agriculture, material science and others. They excel- not only in their non-toxicity and biodegradability but also in their easy preparation. As well as inorganic particles, a protein corona (PC) around polysaccharide nanoparticles is formed in biofluids. Moreover, it has been considered that the overall response of the organism to nanoparticles presence depends on the PC. This review summarises scientific publications about the structural chemistry of polysaccharide nanoparticles and their impact on theranostic applications. Three strategies of implementation of the PC in theranostics have been discussed: I) Utilisation of the PC in therapy; II) How the composition of the PC is analysed for specific disease markers; III) How the formed PC can interact with the immune system and enhances the immunomodulation or immunoelimination. Thus, the findings from this review can contribute to improve the design of drug delivery systems. However, it is still necessary to elucidate the mechanisms of nano-bio interactions and discover new connections in nanoscale research.

Citation

SKALICKOVA, S., HORKY, P., MLEJNKOVA, V., SKLADANDA, J., HOSNEDLOVA, B., RUTTKAY-NEDECKY, B., FERNANDEZ, C. and KIZEK, R. 2021. Theranostic approach for the protein corona of polysaccharide nanoparticles. Chemical record [online], 21(1), pages 17-28. Available from: https://doi.org/10.1002/tcr.202000042

• Journal Article Type: Article
• Acceptance Date: Oct 22, 2020
• Online Publication Date: Nov 16, 2020
• Publication Date: Jan 31, 2021
• Deposit Date: Dec 11, 2020
• Publicly Available Date: Nov 17, 2021
• Journal: Chemical Record
• Print ISSN: 1527-8999
• Electronic ISSN: 1528-0691
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 21
• Issue: 1
• Pages: 17-28
• DOI: https://doi.org/10.1002/tcr.202000042
• Keywords: Chitosan; Diagnostics; Drug delivery; Immune response; Stealth strategy
• Public URL: https://rgu-repository.worktribe.com/output/1005190