Microneedle coating techniques for transdermal drug delivery.

Haj-Ahmad, Rita; Khan, Hashim; Arshad, Muhammad Sohail; Rasekh, Manoochehr; Hussain, Amjad; Walsh, Susannah; Li, Xiang; Chang, Ming-Wei; Ahmad, Zeeshan

Abstract

Drug administration via the transdermal route is an evolving field that provides an alternative to oral and parenteral routes of therapy. Several microneedle (MN) based approaches have been developed. Among these, coated MNs (typically where drug is deposited on MN tips) are a minimally invasive method to deliver drugs and vaccines through the skin. In this review, we describe several processes to coat MNs. These include dip coating, gas jet drying, spray coating, electrohydrodynamic atomisation (EHDA) based processes and piezoelectric inkjet printing. Examples of process mechanisms, conditions and tested formulations are provided. As these processes are independent techniques, modifications to facilitate MN coatings are elucidated. In summary, the outcomes and potential value for each technique provides opportunities to overcome formulation or dosage form limitations. While there are significant developments in solid degradable MNs, coated MNs (through the various techniques described) have potential to be utilized in personalized drug delivery via controlled deposition onto MN templates.

Citation

HAJ-AHMAD, R., KHAN, H., ARSHAD, M.S., RASEKH, M., HUSSAIN, A., WALSH, S., LI, X., CHANG, M.-W. and AHMAD, Z. 2015. Microneedle coating techniques for transdermal drug delivery. Pharmaceutics [online], 7(4), pages 486-502. Available from: https://doi.org/10.3390/pharmaceutics7040486

• Journal Article Type: Article
• Acceptance Date: Oct 28, 2015
• Online Publication Date: Nov 5, 2015
• Publication Date: Dec 31, 2015
• Deposit Date: Aug 22, 2022
• Publicly Available Date: Aug 22, 2022
• Journal: Pharmaceutics
• Electronic ISSN: 1999-4923
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 7
• Issue: 4
• Pages: 486-502
• DOI: https://doi.org/10.3390/pharmaceutics7040486
• Keywords: Microneedles; Coatings; Drug delivery; Coating process; Films; Particles
• Public URL: https://rgu-repository.worktribe.com/output/1609026