Metabolically active cytochrome P450 CYP1B1 in solid tumours: a novel target for chemotherapeutic intervention.

McFadyen, Morag C.E.; Melvin, William T.; Murray, Graeme I.

Abstract

Cytochrome P450 CYP1B1 is a member of a superfamily of haemoproteins that are central to the oxidative metabolism of a wide variety of endogenous and exogenous compounds. Several of these enzymes have an established role in the metabolic bio-transformation of a variety of anti-cancer drugs. In this study, we demonstrated both CYP1B1 and CPR activity in the microsomal fraction of ovarian and kidney tumours.

Citation

MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 2002. Metabolically active cytochrome P450 CYP1B1 in solid tumours: a novel target for chemotherapeutic intervention. Presented at the 2002 British cancer research meeting (BCRM 2002), 30 June - 3 July 2002, Glasgow, UK.

• Presentation Conference Type: Poster
• Conference Name: 2002 British cancer research meeting (BCRM 2002)
• Conference Location: Glasgow, UK
• Start Date: Jun 30, 2002
• End Date: Jul 3, 2002
• Deposit Date: Mar 10, 2023
• Publicly Available Date: Mar 10, 2023
• Publisher: Springer
• Keywords: Cytochrome P450 enzymes; Cancer treatments; Ovarian cancer; Kidney cancer
• Public URL: https://rgu-repository.worktribe.com/output/1905806
• Additional Information: The extended abstract for this poster has been published with the following citation: MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 2002. Metabolically active cytochrome P450 CYP1B1 in solid tumours: a novel target for chemotherapeutic intervention. British journal of cancer [online], 86(Suppl 1): abstracts from the 2002 British cancer research meeting (BCRM 2002), 30 June - 3 July 2002, Glasgow, UK, page S111, poster number P254. Available from: https://doi.org/10.1038/sj.bjc.6600380