Cytochrome P450 CYP1B1: a novel mechanism of drug resistance.

McFadyen, Morag C.E.; Melvin, William T.; Murray, Graeme I.

Abstract

CYP1B1 is a member of the cytochrome P450 enzymes, which are central to the oxidative metabolism of a wide range of substrates, including endogenous compounds involved in cell signaling, environmental carcinogens and anti-cancer drugs. This presentation discusses the authors' recent studies investigating CYP1B1 activity in a number of human tumours and its role in the metabolism of anti-cancer drugs in these tumours.

Citation

MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 2001. Cytochrome P450 CYP1B1: a novel mechanism of drug resistance. Presented at the 2001 British cancer research meeting (BCRM 2001), 1-4 July 2001, Leeds, UK.

• Presentation Conference Type: Lecture
• Conference Name: 2001 British cancer research meeting (BCRM 2001)
• Conference Location: Leeds, UK
• Start Date: Jul 1, 2001
• End Date: Jul 4, 2001
• Deposit Date: Mar 15, 2023
• Publicly Available Date: Mar 15, 2023
• Keywords: Cytochrome P450 enzymes; Cancer; Tumour cells; Chemotherapy
• Public URL: https://rgu-repository.worktribe.com/output/1912320
• Additional Information: The extended abstract for this presentation has been published with the following citation: MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 2001. Cytochrome P450 CYP1B1: a novel mechanism of drug resistance. British journal of cancer [online], 85(Suppl. 1): abstracts from the 2001 British cancer research meeting (BCRM 2001), 1-4 July 2001, Leeds, UK, page 19, abstract number 4.7. Available from: https://doi.org/10.1054/bjoc.2001.1917