Cytochrome P450 in normal human brain and brain tumours.

McFadyen, Morag C.E.; Melvin, William T.; Murray, Graeme I.

Abstract

Cytochromes P450 are a multi-gene family of constitutive and inducible haem-containing enzymes, with a critical role in the oxidative metabolism of a wide range of environmental chemicals - including carcinogens, toxins and therapeutic drugs. P450s may also have a role in cell regulation, given their involvement in the metabolism of physiological chemicals that are active in cellular signalling. This presentation discusses a study investigating the expression of individual P450 mRNAs in normal human brain through reverse transcriptase polymerase chain reaction, and investigating the cellular localisation of P450s in normal brain and brain tumours through immunohistochemistry.

Citation

MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 1997. Cytochrome P450 in normal human brain and brain tumours. Presented at the July 1997 Biochemical Society meeting, 29-31 July 1997, Dundee, UK.

• Presentation Conference Type: Lecture
• Conference Name: July 1997 Biochemical Society meeting
• Conference Location: Dundee, UK
• Start Date: Jul 29, 1997
• End Date: Jul 31, 1997
• Deposit Date: Mar 15, 2023
• Publicly Available Date: Mar 15, 2023
• Keywords: Cytochrome P450 enzymes; Brain tissue; Brain tumours; Brain cancer
• Public URL: https://rgu-repository.worktribe.com/output/1912370
• Additional Information: The extended abstract for this presentation has been published with the following citation: MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 1997. Cytochrome P450 in normal human brain and brain tumours. Biochemical Society transactions [online], 25(4), page S577, abstract number 27. Available from: https://doi.org/10.1042/bst025s577