Cytochrome P450 CYP1B1 in breast cancer.

Murray, G.I.; Buchan, S.; McFadyen, M.C.E.; Miller, I.D.; Payne, S.; Melvin, W.T.

Abstract

This poster gives an overview of recent research into cytochrome P450 CYP1B1, which has previously been shown to present increased expression in several types of human cancer. This study specifically used immunohistochemistry to investigate the expression of CYP1B1 in a series of primary breast cancers. The majority of breast cancers showed positive immunoreactivity for CYP1B1 and this enzyme was specifically localised to tumour cells. This is likely to contribute to breast cancer cells' metabolism of oestradiol and also means that CYP1B1 provides a molecular target for anti-cancer drugs that are specifically activated by this form of P450.

Citation

MURRAY, G.I., BUCHAN, S., MCFADYEN, M.C.E., MILLER, I.D., PAYNE, S. and MELVIN, W.T. 1998. Cytochrome P450 CYP1B1 in breast cancer. Presented at the 1998 Joint special conference of the British Association for Cancer Research and the Royal Society of Medicine (Oncology Section), 7-8 December 1998, London, UK.

• Presentation Conference Type: Poster
• Conference Name: 1998 Joint special conference of the British Association for Cancer Research and the Royal Society of Medicine (Oncology Section)
• Start Date: Dec 7, 1998
• End Date: Dec 9, 1998
• Deposit Date: Mar 15, 2023
• Publicly Available Date: Mar 15, 2023
• Peer Reviewed: Peer Reviewed
• Keywords: Cytochrome P450 enzymes; Breast cancer; Anti-cancer drugs
• Public URL: https://rgu-repository.worktribe.com/output/1912399
• Additional Information: The extended abstract for this poster has been published with the following citation: MURRAY, G.I., BUCHAN, S., MCFADYEN, M.C.E., MILLER, I.D., PAYNE, S. and MELVIN, W.T. 1999. Cytochrome P450 CYP1B1 in breast cancer. British journal of cancer [online], 81(4): carcinogenesis and chemo-prevention: abstracts from the 1998 Joint special conference of the British Association for Cancer Research and the Royal Society of Medicine (Oncology Section), 7-8 December 1998, London, UK, page 580, poster number P9. Available from: https://doi.org/10.1038/sj.bjc.6690733