Purinergic signaling: a common path in the macrophage response against Mycobacterium tuberculosis and Toxoplasma gondii.

Petit-Jentreau, Laetitia; Tailleux, Ludovic; Coombes, Janine L.

doi:10.3389/fcimb.2017.00347

Purinergic signaling: a common path in the macrophage response against Mycobacterium tuberculosis and Toxoplasma gondii.

Petit-Jentreau, Laetitia; Tailleux, Ludovic; Coombes, Janine L.

Authors

Laetitia Petit-Jentreau

Ludovic Tailleux

Janine L. Coombes

Abstract

Immune responses are essential for the protection of the host against external dangers or infections and are normally efficient in the clearance of invading microbes. However, some intracellular pathogens have developed strategies to replicate and survive within host cells resulting in latent infection associated with strong inflammation. This excessive response can cause cell and tissue damage and lead to the release of the intracellular content, in particular the nucleotide pool, into the extracellular space. Over the last decade, new studies have implicated metabolites from the purinergic pathway in shaping the host immune response against intracellular pathogens and proved their importance in the outcome of the infection. This review aims to summarize how the immune system employs the purinergic system either to fight the pathogen, or to control collateral tissue damage. This will be achieved by focusing on the macrophage response against two intracellular pathogens, the human etiologic agent of tuberculosis, Mycobacterium tuberculosis and the protozoan parasite, Toxoplasma gondii.

Citation

PETIT-JENTREAU, L., TAILLEUX, L. and COOMBES, J.L. 2017. Purinergic signaling: a common path in the macrophage response against Mycobacterium tuberculosis and Toxoplasma gondii. Frontiers in cellular and infection microbiology [online], 7, article number 347. Available from: https://doi.org/10.3389/fcimb.2017.00347

Journal Article Type	Review
Acceptance Date	Jul 21, 2017
Online Publication Date	Aug 7, 2017
Publication Date	Dec 31, 2017
Deposit Date	Jul 29, 2024
Publicly Available Date	Jul 29, 2024
Journal	Frontiers in cellular and infection microbiology
Electronic ISSN	2235-2988
Publisher	Frontiers Media
Peer Reviewed	Peer Reviewed
Volume	7
Article Number	347
DOI	https://doi.org/10.3389/fcimb.2017.00347
Keywords	Purinergic agents; Mycobacterium tuberculosis; Toxoplasma gondii; Adenosine triphosphate (ATP); Macrophages; Innate immunity; Nucleotides
Public URL	https://rgu-repository.worktribe.com/output/2058465