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Pharmacological inhibition of acetylcholinesterase improves the locomotion defective phenotype of a SCA3 C. elegans model.

Pohl, Franziska; Lindsay-McGee, Victoria; Kong Thoo Lin, Paul; Maciel, Patricia; Teixera-Castro, Andreia

Authors

Franziska Pohl

Victoria Lindsay-McGee

Patricia Maciel

Andreia Teixera-Castro



Abstract

Inhibition of acetylcholinesterase (AChE) is a common used treatment option for Alzheimer's disease. However, there has been limited research on the potential use of AChE inhibitors for the treatment of Machado-Joseph disease (MJD)/Spinocerebellar Ataxia 3 (SCA3), in spite of the positive results using AChE inhibitors in patients with other inherited ataxias. MJD/SCA3, the most common form of dominant Spinocerebellar Ataxia worldwide, is caused by an expansion of the polyglutamine tract within the ataxin-3 protein, and is characterized by motor impairments. Our study shows that administration of the AChE inhibitor neostigmine is beneficial in treating the locomotion defective phenotype of a SCA3/MJD model of C. elegans and highlights the potential contribution of AChE enzymes to mutant ataxin-3-mediated toxicity.

Citation

POHL, F., LINDSAY-MCGEE, V., KONG THOO LIN, P., MACIEL, P. AND TEIXEIRA-CASTRO, A. 2024. Pharmacological inhibition of acetylcholinesterase improves the locomotion defective phenotype of a SCA3 C. elegans model. microPublication biology [online], 2024(2), 001086. Available from: https://doi.org/10.17912/micropub.biology.001086

Journal Article Type Article
Acceptance Date Feb 2, 2024
Online Publication Date Feb 6, 2024
Publication Date Feb 29, 2024
Deposit Date Feb 12, 2024
Publicly Available Date Feb 12, 2024
Journal microPublication biology
Electronic ISSN 2578-9430
Publisher Caltech Library
Peer Reviewed Peer Reviewed
Volume 2024
Issue 2
Article Number 001086
DOI https://doi.org/10.17912/micropub.biology.001086
Keywords Alzheimer's disease; Treatments; AChE inhibitors
Public URL https://rgu-repository.worktribe.com/output/2242614

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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/

Copyright Statement
© 2024 by the authors. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.





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