Franziska Pohl
Pharmacological inhibition of acetylcholinesterase improves the locomotion defective phenotype of a SCA3 C. elegans model.
Pohl, Franziska; Lindsay-McGee, Victoria; Kong Thoo Lin, Paul; Maciel, Patricia; Teixeira-Castro, Andreia
Authors
Victoria Lindsay-McGee
Paul Kong Thoo Lin
Patricia Maciel
Andreia Teixeira-Castro
Abstract
Inhibition of acetylcholinesterase (AChE) is a common used treatment option for Alzheimer's disease. However, there has been limited research on the potential use of AChE inhibitors for the treatment of Machado-Joseph disease (MJD)/Spinocerebellar Ataxia 3 (SCA3), in spite of the positive results using AChE inhibitors in patients with other inherited ataxias. MJD/SCA3, the most common form of dominant Spinocerebellar Ataxia worldwide, is caused by an expansion of the polyglutamine tract within the ataxin-3 protein, and is characterized by motor impairments. Our study shows that administration of the AChE inhibitor neostigmine is beneficial in treating the locomotion defective phenotype of a SCA3/MJD model of C. elegans and highlights the potential contribution of AChE enzymes to mutant ataxin-3-mediated toxicity.
Citation
POHL, F., LINDSAY-MCGEE, V., KONG THOO LIN, P., MACIEL, P. and TEIXEIRA-CASTRO, A. 2024. Pharmacological inhibition of acetylcholinesterase improves the locomotion defective phenotype of a SCA3 C. elegans model. microPublication biology [online], 2024(2), 001086. Available from: https://doi.org/10.17912/micropub.biology.001086
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 2, 2024 |
Online Publication Date | Feb 6, 2024 |
Publication Date | Feb 29, 2024 |
Deposit Date | Feb 12, 2024 |
Publicly Available Date | Feb 12, 2024 |
Journal | microPublication biology |
Electronic ISSN | 2578-9430 |
Publisher | Caltech Library |
Peer Reviewed | Peer Reviewed |
Volume | 2024 |
Issue | 2 |
Article Number | 001086 |
Pages | 10.17912/micropub.biology.001086 |
DOI | https://doi.org/10.17912/micropub.biology.001086 |
Keywords | Alzheimer's disease; Treatments; AChE inhibitors |
Public URL | https://rgu-repository.worktribe.com/output/2242614 |
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Copyright Statement
© 2024 by the authors. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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