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Aerobic interval exercise improves parameters of Non Alcoholic Fatty Liver Disease (NAFLD) and other alterations of metabolic syndrome in obese Zucker rats.

Kapravelou, Garyfallia; Mart�nez, Rosario; Andrade, Ana M.; Nebot, Elena; Camiletti-Moir�n, Daniel; Aparicio, Virginia A.; Lopez-Jurado, Maria; Aranda, Pilar; Arrebola, Francisco; Fernandez-Segura, Eduardo; Bermano, Giovanna; Goua, Marie; Galisteo, Milagros; Porres, Jesus M.


Garyfallia Kapravelou

Rosario Mart�nez

Ana M. Andrade

Elena Nebot

Daniel Camiletti-Moir�n

Virginia A. Aparicio

Maria Lopez-Jurado

Pilar Aranda

Francisco Arrebola

Eduardo Fernandez-Segura

Milagros Galisteo

Jesus M. Porres


Metabolic syndrome (MS) is a group of metabolic alterations that increase the susceptibility to cardiovascular disease and type 2 diabetes. Nonalcoholic fatty liver disease has been described as the liver manifestation of MS. We aimed to test the beneficial effects of an aerobic interval training (AIT) protocol on different biochemical, microscopic, and functional liver alterations related to the MS in the experimental model of obese Zucker rat. Two groups of lean and obese animals (6 weeks old) followed a protocol of AIT (4 min at 65%-80% of maximal oxygen uptake, followed by 3 min at 50%-65% of maximal oxygen uptake for 45-60 min, 5 days/week, 8 weeks of experimental period), whereas 2 control groups remained sedentary. Obese rats had higher food intake and body weight (P < 0.0001) and suffered significant alterations in plasma lipid profile, area under the curve after oral glucose overload (P < 0.0001), liver histology and functionality, and antioxidant status. The AIT protocol reduced the severity of alterations related to glucose and lipid metabolism and increased the liver protein expression of PPARγ, as well as the gene expression of glutathione peroxidase 4 (P < 0.001). The training protocol also showed significant effects on the activity of hepatic antioxidant enzymes, although this action was greatly influenced by rat phenotype. The present data suggest that AIT protocol is a feasible strategy to improve some of the plasma and liver alterations featured by the MS.


KAPRAVELOU, G., MARTINEZ, R., ANDRADE, A.M., NEBOT, E., CAMILETTI-MOIRON, D., APARICIO, V.A., LOPEZ-JURADO, M., ARANDA, P., ARREBOLA, F., FERNANDEZ-SEGURA, E., BERMANO, G., GOUA, M., GALISTEO, M. and PORRES, J.M. 2015. Aerobic interval exercise improves parameters of Non Alcoholic Fatty Liver Disease (NAFLD) and other alterations of metabolic syndrome in obese Zucker rats. Applied physiology, nutrition and metabolism [online], 40(12), pages 1242-1252. Available from:

Journal Article Type Article
Acceptance Date Jul 30, 2015
Online Publication Date Aug 14, 2015
Publication Date Dec 31, 2015
Deposit Date May 5, 2016
Publicly Available Date May 5, 2016
Journal Applied physiology, nutrition and metabolism
Print ISSN 1715-5312
Electronic ISSN 1715-5320
Publisher NRC Research Press
Peer Reviewed Peer Reviewed
Volume 40
Issue 12
Pages 1242-1252
Keywords Metabolic syndrome; Nonalcoholic fatty liver disease; Aerobic interval training; Arobic capacity; Lipid metabolism; Hepatic metabolic pathways; Liver antioxidant status
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