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Pharmaceutical electrochemistry: the electrochemical detection of asprin utilising screen printed graphene electrodes as sensors platforms.

Kruanetr, Senee; Prabhu, Radhakrishna; Pollard, Pat; Fernandez, Carlos

Authors

Senee Kruanetr

Radhakrishna Prabhu

Pat Pollard

Carlos Fernandez



Abstract

A sensitive electrochemical sensor was designed for acetyl salicylic acid detection using graphene modified Screen Printed Electrodes. The electrochemical response of the sensor with graphene was improved compared to Screen Printed Electrodes without graphene and displayed an excellent analytical performance for the detection of acetyl salicylic acid. The high acetyl salicylic acid loading capacity on the electrode surface and the outstanding electric conductivity of graphene were also discussed in this manuscript. When a range of different concentrations of acetyl salicylic acid from 0.1 to 100 uM into a pH 4 buffer solution (N defined as the sample size N = 9) were plotted against the oxidation peak a linear response was observed. The detection limit was found to be 0.09 'M based on (3-o/slope). Screen Printed Graphene electrodes sensors methodology is shown to be useful for quantifying low levels of acetyl salicylic acid in a buffer solution as well as in biological matrixes such as human oral fluid. A linear response was obtained over a range of concentrations from 10 to 150 uM into a human oral fluid solution (N = 10) giving a detection limit of 8.7 uM.

Journal Article Type Article
Publication Date May 1, 2015
Journal Applied catalysis B: environmental
Print ISSN 0926-3373
Electronic ISSN 1934-8002
Publisher Springer (part of Springer Nature)
Peer Reviewed Peer Reviewed
Volume 51
Issue 3
Pages 283–289
Institution Citation KRUANETR, S., PRABHU, R., POLLARD, P. and FERNANDEZ, C. 2015. Pharmaceutical electrochemistry: the electrochemical detection of asprin utilising screen printed graphene electrodes as sensors platforms. Surface engineering and applied electrochemistry [online], 51(3), pages 283-289. Available from: https://doi.org/10.3103/S1068375515030114
DOI https://doi.org/10.3103/S1068375515030114
Keywords Acetyl salicylic acid; Electrochemical; Sensor; Modified screen printed electrode

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