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Microbubble-liposome conjugate: payload evaluation of potential theranostic vehicle.

Malik, Ritu; Pancholi, Ketan; Melzer, Andreas


Ritu Malik

Andreas Melzer


Liposome–microbubble conjugates are considered as better targeted drug delivery vehicles compared to microbubbles alone. The microbubble in the integrated drug delivery system delivers the drug intracellularly on the target, whereas the liposome component allows loading of high drug dose and extravasation through leaky vasculature. In this work, a new high yielding microbubble production method was used to prepare microbubbles for formulation of the liposome-conjugated drug delivery system. In formulation process, the prepared liposome of 200 nm diameter was attached to the microbubble surface using the avidin–biotin interaction. The analysis of the confocal scanning laser microscope images showed that approximately 8 × 108 microbubbles per millilitre (range: 2–7 μm, mean size 5 ± 0.5 μm) can be efficiently conjugated to the liposomes. The method of conjugation was found to be effective in attaching liposome to microbubbles.


MALIK, R., PANCHOLI, K. and MELZER, A. 2016. Microbubble-liposome conjugate: payload evaluation of potential theranostic vehicle. Nanobiomedicine [online], 3, pages 1-8. Available from:

Journal Article Type Article
Acceptance Date Sep 1, 2016
Online Publication Date Oct 5, 2016
Publication Date Dec 31, 2016
Deposit Date Jan 5, 2017
Publicly Available Date Jan 5, 2017
Journal Nanobiomedicine
Electronic ISSN 1849-5435
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
Volume 3
Pages 1-8
Keywords Liposome microbubble conjugate; Confocal scanning laser microscopy (CSLM); Image correlation spectroscopy (ICS)
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