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Suppository formulations as a potential treatment for nephropathic cystinosis.

Buchan, Barbara; Kay, Graeme; Matthews, Kerr H.; Cairns, Donald

Authors

Barbara Buchan

Graeme Kay

Kerr H. Matthews

Donald Cairns

Abstract

Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of all the organs. It is treated by the 6-h oral administration of the aminothiol, cysteamine, which has an offensive taste and smell. In an attempt to reduce this frequency and improve the treatment, cysteamine-containing polyethylene glycol suppositories were prepared and evaluated for dissolution and stability. The results demonstrated that cysteamine release was complete after 30 min, and that there was a uniform drug distribution within the formulations. Twelve-month stability tests highlighted a potential incompatibility among some excipients, although stability was demonstrated for the cysteamine suppositories up to 6 months. These suppositories may provide a useful alternative to the current oral therapy for cystinosis.

Journal Article Type Article
Publication Date Oct 31, 2012
Journal Journal of pharmaceutical sciences
Print ISSN 0022-3549
Electronic ISSN 1520-6017
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 101
Issue 10
Pages 3729-2738
Institution Citation BUCHAN, B., KAY, G., MATTHEWS, K.H. and CAIRNS, D. 2012. Suppository formulations as a potential treatment for nephropathic cystinosis. Journal of pharmaceutical sciences [online], 101(10), pages 3729-2738. Available from: https://doi.org/10.1002/jps.23246
DOI https://doi.org/10.1002/jps.23246
Keywords Cystinosis; Formulation; PEG; Physical stability; Dissolution; Thermal analysis; Paediatric

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