Barbara Buchan
Suppository formulations as a potential treatment for nephropathic cystinosis.
Buchan, Barbara; Kay, Graeme; Matthews, Kerr H.; Cairns, Donald
Authors
Dr Graeme Kay g.kay@rgu.ac.uk
Associate Dean for ESCD
Dr Kerr Matthews k.h.matthews@rgu.ac.uk
Lecturer
Donald Cairns
Abstract
Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of all the organs. It is treated by the 6-h oral administration of the aminothiol, cysteamine, which has an offensive taste and smell. In an attempt to reduce this frequency and improve the treatment, cysteamine-containing polyethylene glycol suppositories were prepared and evaluated for dissolution and stability. The results demonstrated that cysteamine release was complete after 30 min, and that there was a uniform drug distribution within the formulations. Twelve-month stability tests highlighted a potential incompatibility among some excipients, although stability was demonstrated for the cysteamine suppositories up to 6 months. These suppositories may provide a useful alternative to the current oral therapy for cystinosis.
Citation
BUCHAN, B., KAY, G., MATTHEWS, K.H. and CAIRNS, D. 2012. Suppository formulations as a potential treatment for nephropathic cystinosis. Journal of pharmaceutical sciences [online], 101(10), pages 3729-3738. Available from: https://doi.org/10.1002/jps.23246
Journal Article Type | Article |
---|---|
Acceptance Date | Jun 8, 2012 |
Online Publication Date | Jul 6, 2012 |
Publication Date | Oct 1, 2012 |
Deposit Date | Apr 25, 2017 |
Publicly Available Date | Apr 25, 2017 |
Journal | Journal of pharmaceutical sciences |
Print ISSN | 0022-3549 |
Electronic ISSN | 1520-6017 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 101 |
Issue | 10 |
Pages | 3729-3738 |
DOI | https://doi.org/10.1002/jps.23246 |
Keywords | Cystinosis; Formulation; PEG; Physical stability; Dissolution; Thermal analysis; Paediatric |
Public URL | http://hdl.handle.net/10059/2287 |
Files
BUCHAN 2012 Suppository formulations as a potential
(818 Kb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by-nc-nd/4.0/
You might also like
Oil-based mud waste reclamation and utilisation in low-density polyethylene composites.
(2020)
Journal Article
Characterisation of illicit ecstasy and diazepam tablets by colorant identification.
(2018)
Journal Article
Downloadable Citations
About OpenAIR@RGU
Administrator e-mail: publications@rgu.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search