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Suppository formulations as a potential treatment for nephropathic cystinosis.

Buchan, Barbara; Kay, Graeme; Matthews, Kerr H.; Cairns, Donald


Barbara Buchan

Donald Cairns


Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of all the organs. It is treated by the 6-h oral administration of the aminothiol, cysteamine, which has an offensive taste and smell. In an attempt to reduce this frequency and improve the treatment, cysteamine-containing polyethylene glycol suppositories were prepared and evaluated for dissolution and stability. The results demonstrated that cysteamine release was complete after 30 min, and that there was a uniform drug distribution within the formulations. Twelve-month stability tests highlighted a potential incompatibility among some excipients, although stability was demonstrated for the cysteamine suppositories up to 6 months. These suppositories may provide a useful alternative to the current oral therapy for cystinosis.


BUCHAN, B., KAY, G., MATTHEWS, K.H. and CAIRNS, D. 2012. Suppository formulations as a potential treatment for nephropathic cystinosis. Journal of pharmaceutical sciences [online], 101(10), pages 3729-3738. Available from:

Journal Article Type Article
Acceptance Date Jun 8, 2012
Online Publication Date Jul 6, 2012
Publication Date Oct 1, 2012
Deposit Date Apr 25, 2017
Publicly Available Date Apr 25, 2017
Journal Journal of pharmaceutical sciences
Print ISSN 0022-3549
Electronic ISSN 1520-6017
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 101
Issue 10
Pages 3729-3738
Keywords Cystinosis; Formulation; PEG; Physical stability; Dissolution; Thermal analysis; Paediatric
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