Suppository formulations as a potential treatment for nephropathic cystinosis.

Buchan, Barbara; Kay, Graeme; Matthews, Kerr H.; Cairns, Donald

Abstract

Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of all the organs. It is treated by the 6-h oral administration of the aminothiol, cysteamine, which has an offensive taste and smell. In an attempt to reduce this frequency and improve the treatment, cysteamine-containing polyethylene glycol suppositories were prepared and evaluated for dissolution and stability. The results demonstrated that cysteamine release was complete after 30 min, and that there was a uniform drug distribution within the formulations. Twelve-month stability tests highlighted a potential incompatibility among some excipients, although stability was demonstrated for the cysteamine suppositories up to 6 months. These suppositories may provide a useful alternative to the current oral therapy for cystinosis.

Citation

BUCHAN, B., KAY, G., MATTHEWS, K.H. and CAIRNS, D. 2012. Suppository formulations as a potential treatment for nephropathic cystinosis. Journal of pharmaceutical sciences [online], 101(10), pages 3729-3738. Available from: https://doi.org/10.1002/jps.23246

• Journal Article Type: Article
• Acceptance Date: Jun 8, 2012
• Online Publication Date: Jul 6, 2012
• Publication Date: Oct 1, 2012
• Deposit Date: Apr 25, 2017
• Publicly Available Date: Apr 25, 2017
• Journal: Journal of pharmaceutical sciences
• Print ISSN: 0022-3549
• Electronic ISSN: 1520-6017
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 101
• Issue: 10
• Pages: 3729-3738
• DOI: https://doi.org/10.1002/jps.23246
• Keywords: Cystinosis; Formulation; PEG; Physical stability; Dissolution; Thermal analysis; Paediatric
• Public URL: http://hdl.handle.net/10059/2287
• Contract Date: Apr 25, 2017