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Glassy carbon electrode modified with 7,7,8,8-tetracyanoquinodimethane and graphene oxide triggered a synergistic effect: low-potential amperometric detection of reduced glutathione.

Yuan, Baiqing; Xu, Chunying; Zhang, Renchun; Lu, Donghui; Li, Sujuan; Zhang, Daojun; Liu, Lin; Fernandez, Carlos

Authors

Baiqing Yuan

Chunying Xu

Renchun Zhang

Donghui Lu

Sujuan Li

Daojun Zhang

Lin Liu

Carlos Fernandez



Abstract

A sensitive electrochemical sensor based on the synergistic effect of 7,7,8,8-tetracyanoquinodimethane (TCNQ) and graphene oxide (GO) for low-potential amperometric detection of reduced glutathione (GSH) in pH 7.2 phosphate buffer solution (PBS) has been reported. This is the first time that the combination of GO and TCNQ have been successfully employed to construct an electrochemical sensor for the detection of glutathione. The surface of the glassy carbon electrode (GCE) was modified by a drop casting using TCNQ and GO. Cyclic voltammetric measurements showed that TCNQ and GO triggered a synergistic effect and exhibited an unexpected electrocatalytic activity towards GSH oxidation, compared to GCE modified with only GO, TCNQ or TCNQ/electrochemically reduced GO. Three oxidation waves for GSH were found at −0.05, 0.1 and 0.5 V, respectively. Amperometric techniques were employed to detect GSH sensitively using a GCE modified with TCNQ/GO at −0.05 V. The electrochemical sensor showed a wide linear range from 0.25 to 124.3 μM and 124.3 μM to 1.67 mM with a limit of detection of 0.15 μM. The electroanalytical sensor was successfully applied towards the detection of GSH in an eye drop solution.

Journal Article Type Article
Publication Date Oct 15, 2017
Journal Biosensors and bioelectronics
Print ISSN 0956-5663
Electronic ISSN 1873-4235
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 96
Pages 1-7
Institution Citation YUAN, B., XU, C., ZHANG, R., LU, D., LI, S., ZHANG, D., LIU, L. and FERNANDEZ, C. 2017. Glassy carbon electrode modified with 7,7,8,8-tetracyanoquinodimethane and graphene oxide triggered a synergistic effect: low-potential amperometric detection of reduced glutathione. Biosensors and bioelectronics [online], 96, pages 1-7. Available from: https://doi.org/10.1016/j.bios.2017.04.026
DOI https://doi.org/10.1016/j.bios.2017.04.026
Keywords Electrochemical sensor; 7,7,8,8-tetracyanoquinodimethane (TCNQ); Graphene oxide; Reduced glutathione
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