Kate V. Atkinson
Influenza C in Lancaster, UK, in the winter of 2014-2015.
Atkinson, Kate V.; Bishop, Lisa A.; Rhodes, Glenn; Salez, Nicolas; McEwan, Neil R.; Hegarty, Matthew J.; Robey, Julie; Harding, Nicola; Wetherell, Simon; Lauder, Robert M.; Pickup, Roger W.; Wilkinson, Mark; Gatherer, Derek
Lisa A. Bishop
Neil R. McEwan
Matthew J. Hegarty
Robert M. Lauder
Roger W. Pickup
Influenza C is not included in the annual seasonal influenza vaccine, and has historically been regarded as a minor respiratory pathogen. However, recent work has highlighted its potential role as a cause of pneumonia in infants. We performed nasopharyngeal or nasal swabbing and/or serum sampling (n=148) in Lancaster, UK, over the winter of 2014-2015. Using enzyme-linked immunosorbent assay (ELISA), we obtain seropositivity of 77%. By contrast, only 2 individuals, both asymptomatic adults, were influenza C-positive by polymerase chain reaction (PCR). Deep sequencing of nasopharyngeal samples produced partial sequences for 4 genome segments in one of these patients. Bayesian phylogenetic analysis demonstrated that the influenza C genome from this individual is evolutionarily distant to those sampled in recent years and represents a novel genome constellation, indicating that it may be a product of a decades-old reassortment event. Although we find no evidence that influenza C was a significant respiratory pathogen during the winter of 2014-2015 in Lancaster, we confirm previous observations of seropositivity in the majority of the population.
|Journal Article Type||Article|
|Publication Date||May 26, 2017|
|Publisher||Nature Publishing Group|
|Peer Reviewed||Peer Reviewed|
|Institution Citation||ATKINSON, K.V., BISHOP, L.A., RHODES, G., SALEZ, N., MCEWAN, N.R., HEGARTY, M.J., ROBEY, J., HARDING, N., WETHERELL, S., LAUDER, R.M., PICKUP, R.W., WILKINSON, M. and GATHERER, D. 2017. Influenza C in Lancaster, UK, in the winter of 2014-2015. Scientific reports [online], 7, article number 46578. Available from: https://doi.org/10.1038/srep46578|
|Keywords||Influenza virus; Viral evolution; Respiratory pathogen|
ATKINSON 2017 Influenza C in Lancaster
You might also like
High-starch diets alter equine faecal microbiota and increase behavioural reactivity.