Nano-selenium and its nanomedicine applications: a critical review.

Hosnedlova, Bozena; Kepinska, Marta; Skalickova, Sylvie; Fernandez, Carlos; Ruttkay-Nedecky, Branislav; Peng, Qiuming; Baron, Mojmir; Melcova, Magdalena; Opatrilova, Radka; Zidkova, Jarmila; Bj�rklund, Geir; Sochor, Jiri; Kizek, Rene

Abstract

Traditional supplements of selenium generally have a low degree of absorption and increased toxicity. Therefore, it is imperative to develop innovative systems as transporters of selenium compounds, which would raise the bioavailability of this element and allow its controlled release in the organism. Nanoscale selenium has attracted a great interest as a food additive especially in individuals with selenium deficiency, but also as a therapeutic agent without significant side effects in medicine. This review is focused on the incorporation of nanotechnological applications, in particular exploring the possibilities of a more effective way of administration, especially in selenium-deficient organisms. In addition, this review summarizes the survey of knowledge on selenium nanoparticles, their biological effects in the organism, advantages, absorption mechanisms, and nanotechnological applications for peroral administration.

Citation

HOSNEDLOVA, B., KEPINSKA, M., SKALICKOVA, S., FERNANDEZ, C., RUTTKAY-NEDECKY, B., PENG, Q., BARON, M., MELCOVA, M., OPATRILOVA, R., ZIDKOVA, J., BJORKLUND, G., SOCHOR, J. and KIZEK, R. 2018. Nano-selenium and its nanomedicine applications: a critical review. International journal of nanomedicine [online], 13, pages 2107-2128. Available from: https://doi.org/10.2147/IJN.S157541

• Journal Article Type: Article
• Acceptance Date: Jan 12, 2018
• Online Publication Date: Apr 10, 2018
• Publication Date: Dec 31, 2018
• Deposit Date: Apr 10, 2018
• Publicly Available Date: Apr 10, 2018
• Journal: International journal of nanomedicine
• Print ISSN: 1176-9114
• Electronic ISSN: 1178-2013
• Publisher: Dove Medical Press
• Peer Reviewed: Peer Reviewed
• Volume: 13
• Pages: 2107-2128
• DOI: https://doi.org/10.2147/IJN.S157541
• Keywords: Selenium nanoparticles; Nanodrugs; Nanomedicine; Oxidative stress; Mineral nutrition
• Public URL: http://hdl.handle.net/10059/2867