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The effect of administration of fenbendazole on the microbial hindgut population of the horse.

Crotch-Harvey, Laura; Thomas, Leigh-Anne; Worgan, Hilary J.; Douglas, Jamie-Leigh; Gilby, Diane E.; McEwan, Neil R.


Laura Crotch-Harvey

Leigh-Anne Thomas

Hilary J. Worgan

Jamie-Leigh Douglas

Diane E. Gilby

Neil R. McEwan


Anthelmintics are used as anti-worming agents. Although known to affect their target organisms, nothing has been published regarding their effect on other digestive tract organisms, or metabolites produced by them. The current work investigated effects of fenbendazole, a benzimidazole anthelmintic, on bacteria and ciliates in the equine digestive tract, and their major metabolites. Animals receiving anthelmintic treatment, had high faecal egg counts, relative to controls. Analysis was performed over two weeks, with temporal differences detected in bacterial populations, but with no other significant differences detected. This suggests fenbendazole has no detectable effect on organisms other than its targets. Moreover it does not appear to make a contribution to changing the resulting metabolome.


CROTCH-HARVEY, L., THOMAS, L.-A., WORGAN, H.J., DOUGLAS, J.-L., GILBY, D.E. and MCEWAN, N.R. 2018. The effect of administration of fenbendazole on the microbial hindgut population of the horse. Journal of equine science [online], 29(2), pages 47-51. Available from:

Journal Article Type Article
Acceptance Date Apr 27, 2018
Online Publication Date Jul 6, 2018
Publication Date Jun 30, 2018
Deposit Date Jul 6, 2018
Publicly Available Date Jul 6, 2018
Journal Journal of equine science
Print ISSN 1340-3516
Electronic ISSN 1347-7501
Publisher Japanese Society of Equine Science
Peer Reviewed Peer Reviewed
Volume 29
Issue 2
Pages 47-51
Keywords Bacterial profile; Horse; Metabolome; Worming
Public URL


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