The effect of administration of fenbendazole on the microbial hindgut population of the horse.

Crotch-Harvey, Laura; Thomas, Leigh-Anne; Worgan, Hilary J.; Douglas, Jamie-Leigh; Gilby, Diane E.; McEwan, Neil R.

Abstract

Anthelmintics are used as anti-worming agents. Although known to affect their target organisms, nothing has been published regarding their effect on other digestive tract organisms, or metabolites produced by them. The current work investigated effects of fenbendazole, a benzimidazole anthelmintic, on bacteria and ciliates in the equine digestive tract, and their major metabolites. Animals receiving anthelmintic treatment, had high faecal egg counts, relative to controls. Analysis was performed over two weeks, with temporal differences detected in bacterial populations, but with no other significant differences detected. This suggests fenbendazole has no detectable effect on organisms other than its targets. Moreover it does not appear to make a contribution to changing the resulting metabolome.

Citation

CROTCH-HARVEY, L., THOMAS, L.-A., WORGAN, H.J., DOUGLAS, J.-L., GILBY, D.E. and MCEWAN, N.R. 2018. The effect of administration of fenbendazole on the microbial hindgut population of the horse. Journal of equine science [online], 29(2), pages 47-51. Available from: https://doi.org/10.1294/jes.29.47

• Journal Article Type: Article
• Acceptance Date: Apr 27, 2018
• Online Publication Date: Jul 6, 2018
• Publication Date: Jun 30, 2018
• Deposit Date: Jul 6, 2018
• Publicly Available Date: Jul 6, 2018
• Journal: Journal of equine science
• Print ISSN: 1340-3516
• Electronic ISSN: 1347-7501
• Publisher: Japanese Society of Equine Science
• Peer Reviewed: Peer Reviewed
• Volume: 29
• Issue: 2
• Pages: 47-51
• DOI: https://doi.org/10.1294/jes.29.47
• Keywords: Bacterial profile; Horse; Metabolome; Worming
• Public URL: http://hdl.handle.net/10059/2995