The effect of administration of fenbendazole on the microbial hindgut population of the horse.
Crotch-Harvey, Laura; Thomas, Leigh-Anne; Worgan, Hilary J.; Douglas, Jamie-Leigh; Gilby, Diane E.; McEwan, Neil R.
Hilary J. Worgan
Diane E. Gilby
Neil R. McEwan
Anthelmintics are used as anti-worming agents. Although known to affect their target organisms, nothing has been published regarding their effect on other digestive tract organisms, or metabolites produced by them. The current work investigated effects of fenbendazole, a benzimidazole anthelmintic, on bacteria and ciliates in the equine digestive tract, and their major metabolites. Animals receiving anthelmintic treatment, had high faecal egg counts, relative to controls. Analysis was performed over two weeks, with temporal differences detected in bacterial populations, but with no other significant differences detected. This suggests fenbendazole has no detectable effect on organisms other than its targets. Moreover it does not appear to make a contribution to changing the resulting metabolome.
|Journal Article Type||Article|
|Publication Date||Jun 30, 2018|
|Journal||Journal of equine science|
|Publisher||Japanese Society of Equine Science|
|Peer Reviewed||Peer Reviewed|
|Institution Citation||CROTCH-HARVEY, L., THOMAS, L.-A., WORGAN, H.J., DOUGLAS, J.-L., GILBY, D.E. and MCEWAN, N.R. 2018. The effect of administration of fenbendazole on the microbial hindgut population of the horse. Journal of equine science [online], 29(2), pages 47-51. Available from: https://doi.org/10.1294/jes.29.47|
|Keywords||Bacterial profile; Horse; Metabolome; Worming|
CROTCH-HARVEY 2018 The effect of administration of fenbendazole
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