Pharmaceutical electrochemistry: the electrochemical oxidation of paracetamol and its voltammetric sensing in biological samples based on screen printed graphene electrodes.

Fernandez, Carlos; Heger, Zbynek; Kizek, Rene; Ramakrishnappa, Thippeswamy; Boruń, Agnieszka; Faisal, Nadimul H.

Abstract

We present a sensitive, fast and unmodified sensor for the electrochemical detection of paracetamol. The electrochemical behaviours of paracetamol on screen printed graphene electrodes were investigated for the first time by cyclic voltammetry. The results showed that the screen printed graphene electrodes revealed exceptional electrocatalytic activity to paracetamol. The response showed by this sensor was enhanced when it was compared to the bare screen printed electrodes. When Screen Printed Graphene Electrodes were compared to bare SPE, it was shown that the response with graphene was greater than without. This is due to its unique characteristics physical and chemical, pi-pi interactions and a strong adsorptive capability. In this manuscript, the effect of supporting electrolyte, pH and scan rate were also investigated. The oxidation peak current was linearly proportional to the concentration of paracetamol in the range from 0.1 to 50 mM with a limit of detection of 20nM based on (3-s/slope), under the optimum conditions. The proposed method was successfully applied to paracetamol determination in in biological samples such as human oral fluid.

Citation

FERNANDEZ, C., HEGER, Z., KIZEK, R., RAMAKRISHNAPPA, T., BORUN, A. and FAISAL, N.H. 2015. Pharmaceutical electrochemistry: the electrochemical oxidation of paracetamol and its voltammetric sensing in biological samples based on screen printed graphene electrodes. International journal of electrochemical science [online], 10(9), pages 7440-7452. Available from: https://doi.org/10.1016/S1452-3981(23)17361-5

• Journal Article Type: Article
• Acceptance Date: Jul 11, 2015
• Online Publication Date: Jul 28, 2015
• Publication Date: Sep 30, 2015
• Deposit Date: Sep 15, 2016
• Publicly Available Date: Jun 30, 2023
• Journal: International journal of electrochemical science
• Electronic ISSN: 1452-3981
• Publisher: Electrochemical Science Group
• Peer Reviewed: Peer Reviewed
• Volume: 10
• Issue: 9
• Pages: 7440-7452
• DOI: https://doi.org/10.1016/S1452-3981%2823%2917361-5
• Keywords: Paracetamol; Electrochemical sensor; Real samples; Screen printed graphene electrodes
• Public URL: http://hdl.handle.net/10059/1714
• Publisher URL: http://www.electrochemsci.org/papers/vol10/100907440.pdf
• Contract Date: Sep 15, 2016