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Use of CYP1B1 inhibitors for treating cancer.

Murray, Graeme Ian; Melvin, William Thomas; McFadyen, Morag


Graeme Ian Murray

William Thomas Melvin

Morag McFadyen


CYP1B1 proteins and their role in metabolising or inactivating anti-cancer drugs are disclosed, together with compositions for treating cancer comprising a substance capable of inhibiting CYP1B1 protein and an anti-cancer drug (e.g. docetaxel, paclitaxel, flutamide, tamoxifen, mitoxantrone, doxorubicin or daunomycin).


MURRAY, G.I., MELVIN, W.T. and MCFADYEN, M. 2001. Use of CYP1B1 inhibitors for treating cancer. International patent application PCT/GB2001/000548. International publication number WO/2001/058444 (WO 01/58444 A1), published 16.08.2001. Available from:

Publication Date Aug 16, 2001
Deposit Date Sep 8, 2020
Publicly Available Date Sep 8, 2020
Keywords Cytochrome P450; CYP1B1; Cancer treatments
Public URL
Additional Information Publication number WO/2001/058444 (WO 01/58444 A1). Also published as Australian Patent Office AU2001232060; Canadian Patent Office CA2399402; European Patent Office EP1261332; Japanese Patent Office JP2003522143; US Patent and Trademarks Office US20030162727.


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