Phenome-wide association study of genetically predicted B vitamins and homocysteine biomarkers with multiple health and disease outcomes: analysis of the UK Biobank. [Dataset]

doi:10.1016/j.ajcnut.2023.01.005

All Outputs (4)

Season, storage and extraction method impact on the phytochemical profile of Terminalia ivorensis. (2023)
Journal Article
MOOMIN, A., RUSSELL, W.R., KNOTT, R.M., SCOBBIE, L., MENSAH, K.B., ADU-GYAMFI, P.K.T. and DUTHIE, S.J. 2023. Season, storage and extraction method impact on the phytochemical profile of Terminalia ivorensis. BMC plant biology [online], 23, article number 162. Available from: https://doi.org/10.1186/s12870-023-04144-8

Terminalia ivorensis (TI) is used in West African ethnomedicine for the treatment of conditions including ulcers, malaria and wounds. Despite its widespread use, the phytochemical profile of TI remains largely undetermined. This research investigated... Read More about Season, storage and extraction method impact on the phytochemical profile of Terminalia ivorensis..

Measuring DNA modifications with the comet assay: a compendium of protocols. (2023)
Journal Article
COLLINS, A., MØLLER, P., GAJSKI, G., DUTHIE, S.J. et al. 2023. Measuring DNA modifications with the comet assay: a compendium of protocols. Nature protocols [online], 18, pages 929-989. Available from: https://doi.org/10.1038/s41596-022-00754-y

The comet assay is a versatile method to detect nuclear DNA damage in individual eukaryotic cells, from yeast to human. The types of damage detected encompass DNA strand breaks and alkali-labile sites (e.g., apurinic/apyrimidinic sites), alkylated an... Read More about Measuring DNA modifications with the comet assay: a compendium of protocols..

Phenome-wide association study of genetically predicted B vitamins and homocysteine biomarkers with multiple health and disease outcomes: analysis of the UK Biobank. (2023)
Journal Article
WANG, L., LI, X., MONTAZERI, A., MACFARLANE, A.J., MOMOLI, F., DUTHIE, S., SENEKAL, M., EGUIAGARAY, I.M., MUNGER, R., BENNETT, D., CAMPBELL, H., RUBINI, M., MCNULTY, H., LITTLE, J. and THEODORATOU, E. 2023. Phenome-wide association study of genetically predicted B vitamins and homocysteine biomarkers with multiple health and disease outcomes: analysis of the UK Biobank. American journal of clinical nutrition [online], 117(3), pages 564-575. Available from: https://doi.org/10.1016/j.ajcnut.2023.01.005

Although a number of health outcomes such as cardiovascular diseases, metabolic-related outcomes, neurological disorders, pregnancy outcomes and cancers have been identified in relation to B vitamins, evidence is of uneven quality and volume, and the... Read More about Phenome-wide association study of genetically predicted B vitamins and homocysteine biomarkers with multiple health and disease outcomes: analysis of the UK Biobank..

Phenome-wide association study of genetically predicted B vitamins and homocysteine biomarkers with multiple health and disease outcomes: analysis of the UK Biobank. [Dataset] (2023)
Data
WANG, L., LI, X., MONTAZERI, A., MACFARLANE, A.J., MOMOLI, F., DUTHIE, S., SENEKAL, M., EGUIAGARAY, I.M., MUNGER, R., BENNETT, D., CAMPBELL, H., RUBINI, M., MCNULTY, H., LITTLE, J. and THEODORATOU, E. 2023. Phenome-wide association study of genetically predicted B vitamins and homocysteine biomarkers with multiple health and disease outcomes: analysis of the UK Biobank. [Dataset]. American journal of clinical nutrition [online], 117(3), pages 564-575. Available from: https://doi.org/10.1016/j.ajcnut.2023.01.005

The aim of this study was to explore the effects of B vitamins and homocysteine on a wide range of health outcomes based on a large biorepository linking biological samples and electronic medical records. Significant nonlinear dose-response relations... Read More about Phenome-wide association study of genetically predicted B vitamins and homocysteine biomarkers with multiple health and disease outcomes: analysis of the UK Biobank. [Dataset].