Outputs (5)

Carbon nanomaterials for targeted cancer therapy drugs: a critical review. (2018)
Journal Article
HOSNEDLOVA, B., KEPINSKA, M., FERNANDEZ, C., PENG, Q., RUTTKAY-NEDECKY, B., MILNEROWICZ, H. and KIZEK, R. 2019. Carbon nanomaterials for targeted cancer therapy drugs: a critical review. Chemical record [online], 19(2-3), pages 502-522. Available from: https://doi.org/10.1002/tcr.201800038

Cancer represents one of the main causes of human death in developed countries. Most current therapies, unfortunately, carry a number of side effects, such as toxicity and damage to healthy cells, as well as the risk of resistance and recurrence. The... Read More about Carbon nanomaterials for targeted cancer therapy drugs: a critical review..

Zinc-modified nanotransporter of doxorubicin for targeted prostate cancer delivery. (2017)
Journal Article
SKALICKOVA, S., LOFFELMANN, M., GARGULAK, M., KEPINSKA, M., DOCEKALOVA, M., UHLIROVA, D., STANKOVA, M., FERNANDEZ, C., MILNEROWICZ, H., RUTTKAY-NEDECKY, B. and KIZEK, R. 2017. Zinc-modified nanotransporter of doxorubicin for targeted prostate cancer delivery. Nanomaterials [online], 7(12), article ID 435. Available from: https://doi.org/10.3390/nano7120435

This work investigated the preparation of chitosan nanoparticles used as carriers for doxorubicin for targeted cancer delivery. Prepared nanocarriers were stabilized and functionalized via zinc ions incorporated into the chitosan nanoparticle backbon... Read More about Zinc-modified nanotransporter of doxorubicin for targeted prostate cancer delivery..

A summary of new findings on the biological effects of selenium in selected animal species: a critical review. (2017)
Journal Article
HOSNEDLOVA, B., KEPINSKA, M., SKALICKOVA, S., FERNANDEZ, C., RUTTKAY-NEDECKY, B., MALEVU, T.D., SOCHOR, J., BARON, M., MELCOVA, M., ZIDKOVA, J. and KIZEK, R. 2017. A summary of new findings on the biological effects of selenium in selected animal species: a critical review. International journal of molecular sciences [online], 18(10), paper ID 2209. Available from: https://doi.org/10.3390/ijms18102209

Selenium is an essential trace element important for many physiological processes, especially for the functions of immune and reproductive systems, metabolism of thyroid hormones, as well as antioxidant defense. Selenium deficiency is usually manifes... Read More about A summary of new findings on the biological effects of selenium in selected animal species: a critical review..

Conjugated metallothionein-carbon-doxorubicin nanotransporter for targeted breast cancer therapy.
Presentation / Conference Contribution
SKALIČKOVÁ, S., KEPINSKA, M., LOFFELMANN, M., UHLÍŘOVÁ, D., GARGULÁK, M., DOČEKALOVÁ, M., HOSNEDLOVÁ, B., RUTTKAY-NEDECKÝ, B., MILNEROWICZ, H., FERNANDEZ, C. and KIZEK, R. 2018. Conjugated metallothionein-carbon-doxorubicin nanotransporter for targeted breast cancer therapy. In Proceedings of 10th Nanomaterials international conference 2018 (NANOCON 2018): research and application, 17-19 October 2018, Brno, Czech Republic. Ostrava: Tanger Ltd [online], pages 342-347. Available from: https://www.confer.cz/nanocon/2018/download/193-metallothionein-fullerene-doxorubicin-nanotransporter-conjugates-for-targeted-breast-cancer-therapy.pdf

Metalothionein (MT) is a polypeptide of molecular weight in the range of 6-10 kDa. MT typically contains 60 to 68 amino acid residues. MT is characterized by its unique content of metal ions as well as its sulfur content. Higher MT levels were observ... Read More about Conjugated metallothionein-carbon-doxorubicin nanotransporter for targeted breast cancer therapy..

Zinc-modified nanotransporter of doxorubicine for multi-targeted therapy of prostate cancer cells.
Presentation / Conference Contribution
SKALICKOVA, S., LOFFELMANN, M., DOCEKALOVA, M., UHLIROVA, D., STANKOVA, M., KEPINSKA, M., MILNEROWICZ, H., FERNANDEZ, C., RUTTKAY-NEDECKY, B., ZIDKOVA, J. and KIZEK, R. 2017. Zinc-modified nanotransporter of doxorubicine for multi-targeted therapy of prostate cancer cells. In Proceedings of the 9th Nanomaterials international conference 2017 (NANOCON 2017): research and application, 18-20 October 2017, Brno, Czech Republic. Ostrava: Tanger Ltd [online], pages 531-536. Available from: https://www.confer.cz/nanocon/2017/read/347-zinc-modified-nanotransporter-of-doxorubicine-for-multi-targeted-therapy-of-prostate-cancer-cells.pdf

Target therapy for oncologic diseases presents a big challenge for advance nanomedicine. In our work, we focused on multi-target approach development. Designed nanotransporter is based on polysaccharide chitosan which allows formation of nanoparticle... Read More about Zinc-modified nanotransporter of doxorubicine for multi-targeted therapy of prostate cancer cells..