Outputs (56)

Morphological changes in MCF-7 human breast cancer cells in response to Bis-Naphthalimidopropylspermidine-treatment. (2002)
Journal Article
PAVLOV, V., RODILLA, V. and KONG THOO LIN, P. 2002. Morphological changes in MCF-7 human breast cancer cells in response to Bis-Naphthalimidopropylspermidine-treatment. Biotechnology and biotechnological equipment [online], 16(1), pages 118-123. Available from: https://doi.org/10.1080/13102818.2002.10819165

The effects of bis-naphthalimidopropylspermidine (BNIPSpd), a representative of a novel class of polyamine derivatives with antiproliferative properties on the morphology of MCF-7 human breast cancer cells were studied. BNIPSpd was shown to cause cyt... Read More about Morphological changes in MCF-7 human breast cancer cells in response to Bis-Naphthalimidopropylspermidine-treatment..

Rerefinement of (μ-1,7,11,17-tetraoxa-2,6,12,16-tetraazacycloeicosane-κ4N1,N17:N7,N11)bis[dichlorozinc(II)]. [Dataset] (2002)
Dataset
KUKSA, V.A., WARDELL, S.M.S.V. , KONG THOO LIN, P. and HOWIE, R.A. 2002. Rerefinement of ([mu]-1,7,11,17-tetraoxa-2,6,12,16-tetra­aza­cyclo­ei­cosane-[kappa]4N1,N17:N7,N11)­bis­[di­chlorozinc(II)]. [Dataset]. Acta crystallographica section E: crystallographic communications [online], 58(2), pages m68-m69. Available from: https://doi.org/10.1107/S1600536802001654

This rerefinement of the title compound, [Zn2Cl4(C12H28­N4O4)], based on the original intensity data, differs from the original only in the exchange of the NH and O moieties of the oxa­aza-macrocycle, resulting in a dramatic improvement in the R fact... Read More about Rerefinement of (μ-1,7,11,17-tetraoxa-2,6,12,16-tetraazacycloeicosane-κ4N1,N17:N7,N11)bis[dichlorozinc(II)]. [Dataset].

6-(3,5-Di-O-acetyl-β-D-2-deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7(6H)-one. [Dataset] (1995)
Dataset
VAN MEERVELT, L., KONG THOO LIN, P. and BROWN, D.M. 1995. 6-(3,5-Di-O-acetyl-β-D-2-deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7(6H)-one. [Dataset] Acta crystallographica section C: crystal structure communications [online], 51(7), pages 1347-1350. Available from: https://doi.org/10.1107/s0108270195000096

The title compound, C15H19N3O7 (P), crystallizes with two molecules in the asymmetric unit which differ in sugar and oxazino ring puckering; both occur as the imino tautomer and form P;P wobble base pairs. The supporting information for the published... Read More about 6-(3,5-Di-O-acetyl-β-D-2-deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7(6H)-one. [Dataset].

Direct observation of two base-pairing modes of a cytosine-thymine analogue with guanine in a DNA z-form duplex: significance for base analogue mutagenesis. [Dataset] (1995)
Dataset
MOORE, M.H., VAN MEERVELT, L., SALISBURY, S.A., KONG THOO LIN, P. and BROWN, D.M. 1995. Direct observation of two base-pairing modes of a cytosine-thymine analogue with guanine in a DNA z-form duplex: significance for base analogue mutagenesis. [Dataset]. Hosted on Worldwide Protein Data Bank (wwPDB) [online], 223D. Available from: https://doi.org/10.2210/pdb223d/pdb

The pyrimidine nucleobase analogue 6H,8H-3,4-dihydropyrimido[4,5-c]-[1,2]oxazin-7-one (P) is a mimic both of cytosine and thymine, since it can form stable hydrogen-bonded base-pairs with either guanine or adenine. To investigate the geometric proper... Read More about Direct observation of two base-pairing modes of a cytosine-thymine analogue with guanine in a DNA z-form duplex: significance for base analogue mutagenesis. [Dataset].

Synthesis of oligodeoxyribonucleotides containing degenerate bases and their use as primers in the polymerase chain reaction. (1992)
Journal Article
KONG THOO LIN, P. and BROWN, D.M. 1992. Synthesis of oligodeoxyribonucleotides containing degenerate bases and their use as primers in the polymerase chain reaction. Nucleic acids research [online], 20(19), pages 5149-5152. Available from: https://doi.org/10.1093/nar/20.19.5149

Heptadecaoligodeoxyribonudeotides containing one or more of the bases, 6H,8H-3,4-dihydropyrimido[4,5-c] [1,2]oxazin-7-one (P), 2-amino-6-methoxyaminopurine (K), and hypoxanthine (I) and combinations of P with K and I have been synthesised on a DNA sy... Read More about Synthesis of oligodeoxyribonucleotides containing degenerate bases and their use as primers in the polymerase chain reaction..

Synthesis and duplex stability of oligonucleotides containing cytosine-thymine analogues. (1989)
Journal Article
KONG THOO LIN, P. and BROWN, D.M. 1989. Synthesis and duplex stability of oligonucleotides containing cytosine-thymine analogues. Nucleic acids research [online], 17(24), pages 10373-10383. Available from: https://doi.org/10.1093/nar/17.24.10373

The synthesis of the deoxynucleoside derived from the base P, 6H, 8H-3, 4-dihydro-pyrimido[4, 5-c][1, 2] oxazin-7-one, 2, and its introduction by established phosphoramidite and H-phosphonate chemistry into oligonucleotides is described. The melting... Read More about Synthesis and duplex stability of oligonucleotides containing cytosine-thymine analogues..