The bone biomarker response to an acute bout of exercise: a systematic review with meta-analysis. [Dataset]

Abstract

The aim of this study was to quantify the effects of an acute exercise bout on bone biomarkers, along with the influence of potential moderators such as participant, exercise, and design characteristics, using a systematic review and meta-analytic approach. Bone is a plastic tissue that is responsive to its physical environment. As a result, exercise interventions represent a potential means to influence the bone. However, little is currently known about how various exercise and participant characteristics interact to influence bone metabolism. Acute, controlled, interventions provide an in vivo model through which the acute bone response to exercise can be investigated, typically by monitoring circulating bone biomarkers. Currently, substantial heterogeneity in factors such as study design, quality, exercise, and participant characteristics render it difficult to synthesize and evaluate the available evidence. Using a systematic review and meta-analytic approach, the aim of this investigation is to quantify the effect of an acute exercise bout on circulating bone biomarkers as well as examine the potential factors that may moderate this response, e.g., variation in participant, exercise, and sampling characteristics.

Citation

DOLAN, E., DUMAS, A., KEANE, K.M., BESTETTI, G., FREITAS, L.H.M., GUALANO, B., KOHRT, W.M., KELLY, G.A., PEREIRA, R.M.R., SALE, C. and SWINTON, P.A. 2022. The bone biomarker response to an acute bout of exercise: a systematic review with meta-analysis. [Dataset]. Sports medicine [online], 52(12), pages 2837-2851. Available from: https://tinyurl.com/yc588hx8

• Acceptance Date: Jun 3, 2022
• Online Publication Date: Jul 23, 2022
• Publication Date: Dec 31, 2022
• Deposit Date: Aug 2, 2022
• Publicly Available Date: Jul 24, 2023
• Publisher: Springer
• DOI: https://doi.org/10.1007/s40279-022-01718-8
• Keywords: Biomarkers; Bone response; Exercise; Participant
• Public URL: https://rgu-repository.worktribe.com/output/1724559
• Publisher URL: https://link.springer.com/article/10.1007/s40279-022-01718-8#Sec22
• Related Public URLs: https://rgu-repository.worktribe.com/output/1003590; https://rgu-repository.worktribe.com/output/1681889
• Type of Data: 2 PDF files, 8 DOCX files and accompanying TXT file.
• Collection Date: Jun 3, 2022
• Collection Method: A protocol was designed and prospectively published. Seven databases were systematically searched in accordance with predefined eligibility criteria. Bayesian three-level hierarchical meta-analysis models were used to explore the main effects of acute exercise on bone biomarkers, as well as potential moderating factors. Modelled effect sizes were interpreted according to three metrics, namely (1) evidence of an effect (defined by whether, or how much of, the credible interval [CrI] included zero); (b) the size of that effect (threshold values of 0.01, 0.2, 0.5 and 0.8 were used to describe effect sizes as very small, small, medium and large, respectively); and (c) the level of certainty in the estimated effect (defined using the GRADE framework).