Cytochrome P450 in human brain tumours.

McFadyen, M.C.E.; Melvin, W.T.; Murray, G.I.

Abstract

This presentation reports on a study investigating the presence and cellular localization of individual families of cytochrome P450 enzymes, in both normal brain and primary brain tumours. The immunoreactivity of individual P450s was identified using light microscopic immunohistochemistry. In all cases, positive immunoreactivity for each P450 was identified in tumour cells and, generally, in positively staining cells, the immunoreactivity was strong. The presentation suggests that individual forms of P450 in brain tumours could be important therapeutically for the development of anti-cancer drugs that are activated by those forms of P450.

Citation

MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 1997. Cytochrome P450 in human brain tumours. Presented at the 1997 Joint winter meeting of the British Association for Cancer Research, the Association of Cancer Physicians and the Royal Society of Medicine (Oncology Section), 27-28 November 1997, London, UK.

• Presentation Conference Type: Lecture
• Conference Name: 1997 Joint winter meeting of the British Association for Cancer Research, the Association of Cancer Physicians and the Royal Society of Medicine (Oncology Section)
• Conference Location: London, UK
• Start Date: Nov 27, 1997
• End Date: Nov 28, 1997
• Deposit Date: Mar 15, 2023
• Publicly Available Date: Mar 15, 2023
• Keywords: Cytochrome P450 enzymes; Brain tissue; Brain tumours; Brain cancer
• Public URL: https://rgu-repository.worktribe.com/output/1912390
• Additional Information: The extended abstract for this presentation has been published with the following citation: MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 1998. Cytochrome P450 in human brain tumours. British journal of cancer [online], 78(2): cancer cure: drugs, genes or surgery? Abstracts from the 1997 Joint winter meeting of the British Association for Cancer Research, the Association of Cancer Physicians and the Royal Society of Medicine (Oncology Section), 27-28 November 1997, London, UK, page 153. Available from: https://doi.org/10.1038/bjc.1998.457