Evaluation of new naphthalimides as potential anticancer agents against breast cancer MCF-7, pancreatic cancer BxPC-3 and colon cancer HCT-15 cell lines.

Noro, J.; Maciel, J.; Duarte, D.; Olival, A.C.D.; Baptista, C.; Silva, A.C.D.; Alves, M.J.; Kong Thoo Lin, P.

doi:10.4172/2161-0401.1000144

Evaluation of new naphthalimides as potential anticancer agents against breast cancer MCF-7, pancreatic cancer BxPC-3 and colon cancer HCT-15 cell lines.

Noro, J.; Maciel, J.; Duarte, D.; Olival, A.C.D.; Baptista, C.; Silva, A.C.D.; Alves, M.J.; Kong Thoo Lin, P.

Authors

J. Noro

J. Maciel

D. Duarte

A.C.D. Olival

C. Baptista

A.C.D. Silva

M.J. Alves

Professor Paul Kong Thoo Lin p.v.s.kong-thoo-lin@rgu.ac.uk
Professor

Abstract

New 1,8-naphthalimido derivatives with 2,3 and 4 carbon chains bearing a number of different functionalities were synthesized and tested against a panel of breast cancer MCF-7, colon cancer HCT-15 and pancreatic cancer BxPC-3 cell lines. Generally structures with shorter alkyl chains were more active, with the one exception of the amide containing a p-nitrophenyl group. GI50 values (uM) were determined for the most active compounds. Three compounds exhibited GI50 values below 5 uM, two with MCF-7 cells, and one other with HCT-15. Compounds with different functionalities demonstrated cell line specificity: the MCF-7 cell line was more sensitive to an urea derivative (6f), the growth of HCT- 15 cells were most affected by a triazole (9d), while the BxPC-3 cell line was inhibited in a higher extend by a guanidine (4a).

Citation

NORO, J., MACIEL, J., DUARTE, D., OLIVAL, A.C.D., BAPTISTA, C., SILVA, A.C.D., ALVES, M.J. and KONG THOO LIN, P. 2015. Evaluation of new naphthalimides as potential anticancer agents against breast cancer MCF-7, pancreatic cancer BxPC-3 and colon cancer HCT-15 cell lines. Organic chemistry: current research [online], 4(3), ID 1000144. Available from: https://doi.org/10.4172/2161-0401.1000144

Journal Article Type	Article
Acceptance Date	Jul 13, 2015
Online Publication Date	Jul 20, 2015
Publication Date	Sep 30, 2015
Deposit Date	Apr 20, 2016
Publicly Available Date	Apr 20, 2016
Journal	Organic chemistry: current research
Electronic ISSN	2161-0401
Publisher	OMICS International
Peer Reviewed	Peer Reviewed
Volume	4
Issue	3
Article Number	1000144
DOI	https://doi.org/10.4172/2161-0401.1000144
Keywords	Toxicity; Tetrabromide; Naphthalimide; Isocyanate; Membrane permeabilisation
Public URL	http://hdl.handle.net/10059/1446