Exploiting the antiparasitic activity of naphthalimides derivatives.

Cristo, Gabriela; Gaspar, Lu�s; Noro, Jennifer; Baptista, Catarina; Kong Thoo Lin, Paul; Alves, Maria Jos�; Cordeiro-Da-Silva, Anabela

Abstract

A set of 1,8-naphtalimides derivatives were synthesized and tested against three protozoans that cause important human diseases: Leishmania infantum, Trypanosomabrucei and Trypanosoma cruzi. Additionally, toxicity was determined by growth inhibition of THP-1 derived macrophages. The results suggest that chemical modifications in the carbon chain linking the naphthalimide and the substituting groups have different effects in the parasites. This work should provide new insights for the design and optimization of more potent and directed naphthalimide derivatives against these organisms.

Citation

CRISTO, G., GASPAR, L., NORO, J., BAPTISTA, C., KONG THOO LIN, P., ALVES, M.J. and CORDEIRO-DA-SILVA, A. 2016. Exploiting the antiparasitic activity of naphthalimides derivatives. International journal of chemistry and pharmaceutical sciences [online], 4(1), pages 19-23. Available from: http://www.pharmaresearchlibrary.com/wp-content/uploads/2016/06/IJCPS2793.pdf

• Journal Article Type: Article
• Acceptance Date: Dec 26, 2015
• Online Publication Date: Jan 27, 2016
• Publication Date: Jan 31, 2016
• Deposit Date: Mar 23, 2020
• Publicly Available Date: May 8, 2020
• Journal: International journal of chemistry and pharmaceutical sciences
• Electronic ISSN: 2321-3132
• Publisher: Pharma Research Library
• Peer Reviewed: Peer Reviewed
• Volume: 4
• Issue: 1
• Pages: 19-23
• Keywords: Leishmania infantum; Trypanosoma brucei; Trypanosoma cruzi
• Public URL: https://rgu-repository.worktribe.com/output/865378
• Publisher URL: http://www.pharmaresearchlibrary.com/ijcps-2016-volume-4-issue-1/