Adipocytokines and their relationship to endometrial cancer risk: a systematic review and meta-analysis.

Ellis, Patricia E.; Barron, Gemma A.; Bermano, Giovanna

Abstract

Objective:- To investigate the association between circulating levels of adipocytokines (adiponectin, leptin, tumour necrosis factor alpha (TNFα), interleukin 6 (IL-6)) and growth factors (insulin-like growth factor I (IGF-I) and II (IGF-II)), and the risk of endometrial cancer. Methods:- Cochrane, CINAHL, Embase, Medline and Web of Science were searched for English-language manuscripts published between January 2000 and August 2018 using the following string of words: cancer and endometrial and (obesity or BMI) and (adiponectin or TNF* or IGF-I or IGF-II or IL-6 or leptin). Results:- Twenty articles were included in this meta-analysis, which corresponded to 18 studies involving 2921 endometrial carcinoma cases and 5302 controls. Fourteen articles reported circulating levels for adiponectin, seven for leptin, three for TNFα, three for IL-6 and one for IGF- I. No article reported values for IGF- II. Patients with circulating adiponectin levels in the highest tertile had decreased endometrial cancer risk compared to women with levels in the lowest tertile, (summary of odds ratio (SOR) 0.51, 95% CI: 0.38-0.69, p[less than]0.00001). Women with circulating leptin concentrations in the highest tertile had increased endometrial cancer risk compared to women with concentrations in the lowest tertile (SOR 2.19, 95% CI: 1.45-3.30, p=0.0002). There was no difference in cancer risk between participants with the highest TNFα and IL-6 levels compared to the lowest levels (SOR 1.27, 95% CI: 0.88-1.83, p=0.20 and SOR 1.20, 95% CI: 0.89-1.63, p=0.23, respectively). Conclusions:- Endometrial cancer risk is inversely affected by adiponectin and leptin levels. There appears to be no relationship between TNF-α and IL- 6 and the overall risk of endometrial cancer.

Citation

ELLIS, P.E., BARRON, G.A., and BERMANO, G. 2020. Adipocytokines and their relationship to endometrial cancer risk: a systematic review and meta-analysis. Gynecologic oncology [online], 158(2), pages 507-516. Available from: https://doi.org/10.1016/j.ygyno.2020.05.033

• Journal Article Type: Review
• Acceptance Date: May 21, 2020
• Online Publication Date: Jun 5, 2020
• Publication Date: Aug 1, 2020
• Deposit Date: May 25, 2020
• Publicly Available Date: Jun 6, 2021
• Journal: Gynecologic oncology
• Print ISSN: 0090-8258
• Electronic ISSN: 1095-6859
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 158
• Issue: 2
• Pages: 507-516
• DOI: https://doi.org/10.1016/j.ygyno.2020.05.033
• Keywords: Endometrial cancer; Obesity; Adipocytokines; Risk factors; Meta-analysis
• Public URL: https://rgu-repository.worktribe.com/output/918078