Açaí (Euterpe oleracea Martius) supplementation in the diet during gestation and lactation attenuates liver steatosis in dams and protects offspring.

Barbosa, Priscila O.; de Souza, Melina O.; Paiva, Deuziane P. D.; Silva, Marcelo E.; Lima, Wanderson G.; Bermano, Giovanna; Freitas, Renata N.

Abstract

Purpose: Maternal high-fat diet affects offspring and can induce metabolic disorders such as non-alcoholic fatty liver disease (NAFLD). New therapeutic strategies are being investigated as way to prevent or attenuate this condition. The objective of this study was to evaluate the effect of açaí supplementation in the maternal high-fat diet on dams and offspring lipid metabolism. Methods: Female Fisher rats were divided in four groups and fed a control diet (C), a high-fat diet (HF), an açaí supplemented diet (CA) and a high-fat diet supplemented with açaí (HFA) 2 weeks before mating, during gestation and lactation. The effects of açaí were evaluated in the male offspring after birth (P1) and weaning (P21). Results: HFA reduced relative liver weight, fat and cholesterol liver content in dams and improved liver steatosis as confirmed by histological analyses. HFA increased serum cholesterol and expression of Srebpf1 and Fasn genes. In offspring, HFA decreased relative liver weight, and serum cholesterol only in P21. An increase in the Sirt1, Srebpf1 and Fasn genes expression was observed in P21. Conclusions: These results suggest that açaí supplementation may attenuate NAFLD in dams and protect offspring from the detrimental effects of lipid excess from a maternal high-fat diet.

Citation

BARBOSA, P.O., DE SOUZA, M.O., PAIVA, D.P.D., SILVA, M.E., LIMA, W.G., BERMANO, G. and FREITAS, R.N. 2020. Açaí (Euterpe oleracea Martius) supplementation in the diet during gestation and lactation attenuates liver steatosis in dams and protects offspring. European journal of nutrition [online], 59(5), pages 1595-1908. Available from: https://doi.org/10.1007/s00394-019-02040-2

• Journal Article Type: Article
• Acceptance Date: Jun 29, 2019
• Online Publication Date: Jul 5, 2019
• Publication Date: Aug 31, 2020
• Deposit Date: Jul 10, 2019
• Publicly Available Date: Jul 6, 2020
• Journal: European journal of nutrition
• Print ISSN: 1436-6207
• Electronic ISSN: 1436-6215
• Publisher: Springer
• Peer Reviewed: Peer Reviewed
• Volume: 59
• Issue: 5
• Pages: 1895-1908
• DOI: https://doi.org/10.1007/s00394-019-02040-2
• Keywords: Açaí; Euterpe oleracea Martius; High-fat maternal diet; Metabolic programming; Non-alcoholic fatty liver disease
• Public URL: https://rgu-repository.worktribe.com/output/320294
• Contract Date: Jul 10, 2019