Skip to main content

Research Repository

Advanced Search

All Outputs (1206)

An investigation into factors influencing the production and degradation of microcystins. (2007)
Thesis
GRAHAM, D.J.L. 2007. An investigation into factors influencing the production and degradation of microcystins. Robert Gordon University, PhD thesis.

Microcystins (MCYST) potently inhibit protein phosphatases and these cyclic heptapeptides are powerful hepatotoxins. They are known to be secondary metabolites produced by several species of cyanobacteria. The release of these peptides into water sup... Read More about An investigation into factors influencing the production and degradation of microcystins..

Bioactivity of two Turkish endemic centaurea species, and their major constituents. (2007)
Journal Article
SHOEB, M., MACMANUS, S.M., JASPARS, M., KONG THOO LIN, P., NAHAR, L., CELIK, S. and SARKER, S.D. 2007. Bioactivity of two Turkish endemic centaurea species, and their major constituents. Revista Brasileira de Farmacognosia/Brazilian journal of pharmacognosy [online], 17(2), pages 155-159. Available from: https://doi.org/10.1590/S0102-695X2007000200003

The antioxidant activity, general toxicity and cytotoxicity of the methanol extracts of Centaurea urvillei subs, armata and C. mucronifera have been assessed, respectively, by the DPPH assay, the brine shrimp lethality and the MTT cytotoxicity assays... Read More about Bioactivity of two Turkish endemic centaurea species, and their major constituents..

Aggregation of Staphylococcus aureus following treatment with the antibacterial flavonol galangin. (2007)
Journal Article
CUSHNIE, T.P.T., HAMILTON, V.E.S., CHAPMAN, D.G., TAYLOR, P.W. and LAMB, A.J. 2007. Aggregation of Staphylococcus aureus following treatment with the antibacterial flavonol galangin. Journal of applied microbiology [online], 103(5), pages 1562-1567. Available from: https://doi.org/10.1111/j.1365-2672.2007.03393.x

Aim: The flavonol galangin, an antimicrobial constituent of the traditional medicines propolis and Helichrysum aureonitens, is being assessed as part of an ongoing investigation into the antibacterial activity of flavonoids. The present study sought... Read More about Aggregation of Staphylococcus aureus following treatment with the antibacterial flavonol galangin..

Detection, analysis, and photocatalytic destruction of the freshwater taint compound geosmin. (2007)
Thesis
BELLU, E. 2007. Detection, analysis, and photocatalytic destruction of the freshwater taint compound geosmin. Robert Gordon University, PhD thesis.

A significant issue affecting the aquaculture and water industries is the presence of off-flavour compounds in water, which cause problems by imparting an undesirable earthy/musty flavour and smell to water and fish. Two predominant off-flavour compo... Read More about Detection, analysis, and photocatalytic destruction of the freshwater taint compound geosmin..

Molecular mechanisms of nutrient mediated regulation of hypoxia inducible factor -1a(HIF-1a) in endothelial cells. (2007)
Thesis
HECTOR, E.E. 2007. Molecular mechanisms of nutrient mediated regulation of hypoxia inducible factor -1a(HIF-1a) in endothelial cells. Robert Gordon University, PhD thesis.

Poorly-controlled diabetes mellitus is associated with the development of chronic vascular complications, which cause morbidity and premature mortality. Many studies have highlighted that maintenance of normal blood glucose levels in all people with... Read More about Molecular mechanisms of nutrient mediated regulation of hypoxia inducible factor -1a(HIF-1a) in endothelial cells..

Fatty acid and phospholipid chlorohydrins cause cell stress and endothelial adhesion. (2006)
Journal Article
DEVER, G., WAINWRIGHT, C. L., KENNEDY, S. and SPICKETT, C. M. 2006. Fatty acid and phospholipid chlorohydrins cause cell stress and endothelial adhesion. Acta biochimica polonica [online], 53(4), pages 761-768. Available from: https://doi.org/10.18388/abp.2006_3304

The oxidation of low-density lipoprotein (LDL) is thought to contribute to atherogenesis, which is an inflammatory disease involving activation of phagocytic cells. Myeloperoxidase, an enzyme which is able to produce hypochlorous acid (HOCl), is rele... Read More about Fatty acid and phospholipid chlorohydrins cause cell stress and endothelial adhesion..

The application of Raman and anti-stokes Raman spectroscopy for in-situ monitoring of structural changes in laser irradiated titanium dioxide materials. (2006)
Journal Article
RIGBY, S.J., AL-OBAIDI, A.H.R., LEE, S.-K., McSTAY, D. and ROBERTSON, P.K.J. 2006. The application of Raman and anti-stokes Raman spectroscopy for in-situ monitoring of structural changes in laser irradiated titanium dioxide materials. Applied surface science [online], 252(22), pages 7948-7952. Available from: https://doi.org/10.1016/j.apsusc.2005.10.003

The use of Raman and anti-stokes Raman spectroscopy to investigate the effect of exposure to high power laser radiation on the crystalline phases of TiO 2 has been investigated. Measurement of the changes, over several time integrals, in the Raman an... Read More about The application of Raman and anti-stokes Raman spectroscopy for in-situ monitoring of structural changes in laser irradiated titanium dioxide materials..

Photo-dynamic biocidal action of methylene blue and hydrogen peroxide on the cyanobacterium Synechococcus leopoliensis under visible light irradiation. (2006)
Journal Article
MCCULLAGH, C. and ROBERTSON, P.K.J. 2006. Photo-dynamic biocidal action of methylene blue and hydrogen peroxide on the cyanobacterium Synechococcus leopoliensis under visible light irradiation. Journal of photochemistry and photobiology B: biology [online], 83(1), pages 63-68. Available from: https://doi.org/10.1016/j.jphotobiol.2005.11.013

Biofilm growth on stone surfaces is a significant contributing factor to stone biodeterioration. Current market based biocides are hazardous to the environment and to public health. We have investigated the photo-dynamic effect of methylene blue (MB)... Read More about Photo-dynamic biocidal action of methylene blue and hydrogen peroxide on the cyanobacterium Synechococcus leopoliensis under visible light irradiation..

The development and application of statistical sampling regime to map out hydrocarbons in sediments. (2005)
Thesis
AHMED, A.S. 2005. The development and application of statistical sampling regime to map out hydrocarbons in sediments. Robert Gordon University, PhD thesis.

This thesis investigates and develops a stratified random sampling design for sediments in an offshore oil field environment. The sampling area was partitioned equally into sixteen zones. Stratification was based on the near-field and far-field areas... Read More about The development and application of statistical sampling regime to map out hydrocarbons in sediments..

The photocatalytic destruction of the cyanotoxin, nodularin using Ti02. (2005)
Journal Article
LIU, I., LAWTON, L.A., BAHNEMANN, D.W. and ROBERTSON, P.K.J. 2005. The photocatalytic destruction of the cyanotoxin, nodularin using Ti02. Applied catalysis B: environmental [online], 60(3-4), pages 245-252. Available from: https://doi.org/10.1016/j.apcatb.2005.03.006

Titanium dioxide (TiO2) photocatalysis has been used to initiate the destruction of nodularin, a natural hepatotoxin produced by cyanobacteria. The destruction process was monitored using liquid chromatography-mass spectrometry analysis which has als... Read More about The photocatalytic destruction of the cyanotoxin, nodularin using Ti02..

A comparison of the effectiveness of TiO2 photocatalysis and UVA photolysis for the destruction of three pathogenic micro-organisms. (2005)
Journal Article
ROBERTSON, J.M.C., ROBERTSON, P.K.J. and LAWTON, L.A. 2005. A comparison of the effectiveness of TiO2 photocatalysis and UVA photolysis for the destruction of three pathogenic micro-organisms. Journal of photochemistry and photobiology A: chemistry [online], 175(1), pages 51-56. Available from: https://doi.org/10.1016/j.jphotochem.2005.04.033

TiO2 photocatalysis has demonstrated efficacy as a treatment process for water contaminated with chemical pollutants. When exposed to UVA light TiO2 also demonstrates an effective bactericidal activity. The mechanism of this process has been reported... Read More about A comparison of the effectiveness of TiO2 photocatalysis and UVA photolysis for the destruction of three pathogenic micro-organisms..

Occurrence of toxigenic cyanobacterial blooms in freshwaters of Sri Lanka. (2005)
Journal Article
JAYATISSA, L.P., SILVA, E.I.L., MCELHINEY, J. and LAWTON, L.A. 2006. Occurrence of toxigenic cyanobacterial blooms in freshwaters in Sri Lanka. Systematic and applied microbiology [online], 29(2), pages 156-164. Available from: https://doi.org/10.1016/j.syapm.2005.07.007

A previous pioneering study of freshwater bodies in Sri Lanka revealed the presence of toxic cyanobacteria in three out of four water bodies tested. It was therefore important to perform a more detailed investigation into the presence of cyanobacteri... Read More about Occurrence of toxigenic cyanobacterial blooms in freshwaters of Sri Lanka..

Alternative strategies for security labelling/encoding of paper and plastic products. (2005)
Thesis
OFFICER, S.J. 2005. Alternative strategies for security labelling/encoding of paper and plastic products. Robert Gordon University, PhD thesis.

A literature and patent review of current optical security techniques has been carried out and identified a need in the market for an improved optical security label to rival molecular fluorescent dyes. The label proposed was a rare earth (RE) doped... Read More about Alternative strategies for security labelling/encoding of paper and plastic products..

Cytochrome P450 CYP1B1 activity in renal cell carcinoma. (2004)
Journal Article
MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 2004. Cytochrome P450 CYP1B1 activity in renal cell carcinoma. British journal of cancer [online], 91, pages 966-971. Available from: https://doi.org/10.1038/sj.bjc.6602053

Renal cell carcinoma (RCC) is the most common malignancy of the kidney and has a poor prognosis due to its late presentation and resistance to current anticancer drugs. One mechanism of drug resistance, which is potentially amenable to therapeutic in... Read More about Cytochrome P450 CYP1B1 activity in renal cell carcinoma..

Two oxazane macrocycles. (2004)
Journal Article
COX, P.J. and KONG THOO LIN, P. 2004. Two oxazane macrocycles. Acta crystallographica section C: structural chemistry [online], 60(5), pages o321-o324. Available from: https://doi.org/10.1107/S0108270104006687

The 20-membered ring in 1,7,11,17-tetraoxa-2,6,12,16-tetraazacycloeicosane tetrahydrochloride, C12H32N4O44+·4Cl-, adopts an endo conformation, while the 18-membered ring in 1,6,10,15-tetraoxa-2,5,11,14-tetraazacyclooctadecane tetrahydrochloride, C10H... Read More about Two oxazane macrocycles..

On-line monitoring of laser modification of titanium dioxide using optical surface second harmonic. (2004)
Journal Article
VRILLET, G., LEE, S.K., McSTAY, D. and ROBERTSON, P.K.J. 2004. On-line monitoring of laser modification of titanium dioxide using optical surface second harmonic. Applied surface science [online], 222(1-4), pages 33-42. Available from: https://doi.org/10.1016/j.apsusc.2003.07.003

TiO2 photocatalysis is a promising technology for the destruction of organic pollutants in both waste and potable waters with the mineralisation of a wide range of compounds having been reported. TiO2 has many advantages over other semiconductors, it... Read More about On-line monitoring of laser modification of titanium dioxide using optical surface second harmonic..

Anti-cancer drug interaction with cytochrome P450 CYP1B1. (2003)
Presentation / Conference
MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 2003. Anti-cancer drug interaction with cytochrome P450 CYP1B1. Presented at the 2003 British cancer research meeting (BCRM 2003), 2-5 July 2003, Bournemouth, UK.

One mechanism potentially amenable to chemotherapeutic intervention involves cytochrome P450 CYP1B1. Our research has established the concept of over-expression of individual forms of cytochrome P450 - in particular CYP1B1 - in a range of solid tumou... Read More about Anti-cancer drug interaction with cytochrome P450 CYP1B1..

School-based drug education in Northeast Scotland: policy, planning and practice. (2003)
Thesis
FITZGERALD, N. 2003. School-based drug education in Northeast Scotland: policy, planning and practice. Robert Gordon University, PhD thesis.

This research utilised qualitative methods to gain a deeper insight into the policy, planning and practice of school-based drug education than had previously been achieved in Scotland. Semi-structured interviews were carried out with staff in nine Gr... Read More about School-based drug education in Northeast Scotland: policy, planning and practice..

The managed entry of new drugs into a National Health Service: a case study for Malta. (2003)
Thesis
BONANNO, P.V. 2003. The managed entry of new drugs into a National Health Service: a case study for Malta. Robert Gordon University, PhD thesis.

The research question was to determine if it is possible to develop a systematic approach to the managed entry of new drugs into a National Health Service( NHS), using Malta as a case study. In early 1999, Malta had major problems with the managed en... Read More about The managed entry of new drugs into a National Health Service: a case study for Malta..