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Synthesis and evaluation of polymer-drug conjugates as potential antioxidant and cholinesterase inhibitors for neurodegenerative diseases. (2024)
Journal Article
MAHADIK, N., BARRON, G., KONG THOO LIN, P. and THOMPSON, C. 2024. Synthesis and evaluation of polymer-drug conjugates as potential antioxidant and cholinesterase inhibitors for neurodegenerative diseases. Chemistry of materials [online], 36(21), pages 10514-10527. Available from: https://doi.org/10.1021/acs.chemmater.4c01767

Polymer-drug conjugates (PDCs) may offer improved water-solubility and in vitro activity of potential antioxidant and cholinesterase (ChE) inhibitor drugs compared to the drugs alone. Conjugation of these potential drugs to water-soluble polymers cou... Read More about Synthesis and evaluation of polymer-drug conjugates as potential antioxidant and cholinesterase inhibitors for neurodegenerative diseases..

Polymer-drug conjugates as nano-sized multi-targeting systems for the treatment of Alzheimer's disease. (2024)
Journal Article
MAHADIK, N., BARRON, G.A., KONG THOO LIN, P. and THOMPSON, C.J. 2024. Polymer-drug conjugates as nano-sized multi-targeting systems for the treatment of Alzheimer's disease. RSC pharmaceutics [online], 1(2), pages 161-181. Available from: https://doi.org/10.1039/D3PM00075C

Alzheimer's disease (AD) is a progressive, neurodegenerative condition. There are clear markers for the presence and progression of the disease, including β-amyloid (Aβ) plaques and Tau tangles, with many potential causes debated in the scientific co... Read More about Polymer-drug conjugates as nano-sized multi-targeting systems for the treatment of Alzheimer's disease..

Adipocytokines and their relationship to endometrial cancer risk: a systematic review and meta-analysis. (2020)
Journal Article
ELLIS, P.E., BARRON, G.A., and BERMANO, G. 2020. Adipocytokines and their relationship to endometrial cancer risk: a systematic review and meta-analysis. Gynecologic oncology [online], 158(2), pages 507-516. Available from: https://doi.org/10.1016/j.ygyno.2020.05.033

Objective:- To investigate the association between circulating levels of adipocytokines (adiponectin, leptin, tumour necrosis factor alpha (TNFα), interleukin 6 (IL-6)) and growth factors (insulin-like growth factor I (IGF-I) and II (IGF-II)), and th... Read More about Adipocytokines and their relationship to endometrial cancer risk: a systematic review and meta-analysis..

Açaí (Euterpe oleracea Martius) supplementation in the diet during gestation and lactation attenuates liver steatosis in dams and protects offspring. (2019)
Journal Article
BARBOSA, P.O., DE SOUZA, M.O., PAIVA, D.P.D., SILVA, M.E., LIMA, W.G., BERMANO, G. and FREITAS, R.N. 2020. Açaí (Euterpe oleracea Martius) supplementation in the diet during gestation and lactation attenuates liver steatosis in dams and protects offspring. European journal of nutrition [online], 59(5), pages 1595-1908. Available from: https://doi.org/10.1007/s00394-019-02040-2

Purpose: Maternal high-fat diet affects offspring and can induce metabolic disorders such as non-alcoholic fatty liver disease (NAFLD). New therapeutic strategies are being investigated as way to prevent or attenuate this condition. The objective of... Read More about Açaí (Euterpe oleracea Martius) supplementation in the diet during gestation and lactation attenuates liver steatosis in dams and protects offspring..

Circulating levels of angiogenesis-related growth factors in breast cancer: a study to profile proteins responsible for tubule formation. (2017)
Journal Article
BARRON, G.A., GOUA, M., WAHLE, K.W.J. and BERMANO, G. 2017. Circulating levels of angiogenesis-related growth factors in breast cancer: a study to profile proteins responsible for tubule formation. Oncology reports [online], 38(3), pages 1886-1894. Available from: https://doi.org/10.3892/or.2017.5803

The present study exploited a versatile in vitro endothelial cell/fibroblast co-culture cell system to investigate the association between angiogenesis and breast cancer by comparing the capacity of plasma from women with breast cancer and age-matche... Read More about Circulating levels of angiogenesis-related growth factors in breast cancer: a study to profile proteins responsible for tubule formation..

Novel bisnaphthalimidopropyl (BNIPs) derivatives as anticancer compounds targeting DNA in human breast cancer cells. (2016)
Journal Article
KOPSIDA, M., BARRON, G.A. BERMANO, G., KONG THOO LIN, P. and GOUA, M. 2016. Novel bisnaphthalimidopropyl (BNIPs) derivatives as anticancer compounds targeting DNA in human breast cancer cells. Organic and biomolecular chemistry [online], 14(41), pages 9780-9789. Available from: https://doi.org/10.1039/C6OB01850E

Bisnaphthalimidopropyl (BNIP) derivatives are a family of compounds that exert anti-cancer activities in vitro and, according to previous studies, variations in the linker sequence have increased their DNA binding and cytotoxic activities. By modifyi... Read More about Novel bisnaphthalimidopropyl (BNIPs) derivatives as anticancer compounds targeting DNA in human breast cancer cells..

Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression. (2015)
Journal Article
BARRON, G.A., GOUA, M., KURAOKA, I., BERMANO, G., IWAI, S. and KONG THOO LIN, P. 2015. Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression. Chemico-biological interactions [online], 242, pages 307-315. Available from: https://doi.org/10.1016/j.cbi.2015.10.017

Bisnaphthalimidopropyl diaminodicyclohexylmethane (BNIPDaCHM) bisintercalates to DNA and is a potential anti-cancer therapeutic. In an attempt to elucidate the mechanism(s) underlying the potential of BNIPDaCHM; earlier work was extended to investiga... Read More about Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression..

Modulation of angiogenesis by inflammatory markers and the role of matrix metalloproteinases in an endothelial cell/fibroblast co-culture system. (2014)
Journal Article
BARRON, G.A., BORDET, E., GOUA, M. and BERMANO. G. 2014. Modulation of angiogenesis by inflammatory markers and the role of matrix metalloproteinases in an endothelial cell/fibroblast co-culture system. Current angiogenesis [online], 3(3), pages 152-163. Available from: https://doi.org/10.2174/2211552803666141113211829

Increased levels of inflammatory markers such as tumour necrosis factor-α (TNFα) and interleukin- 6 (IL-6) have been associated with formation of new blood vessels, or angiogenesis, and linked to chronic inflammation in obesity. This study aimed to e... Read More about Modulation of angiogenesis by inflammatory markers and the role of matrix metalloproteinases in an endothelial cell/fibroblast co-culture system..