Professor Cherry Wainwright's Outputs (26)

Studies to determine the mechanisms of the anti-atherosclerotic effects of eicosapentaenoic acid: possible role for endocannabinoids? (2012)
Thesis
MICHEL, L. 2012. Studies to determine the mechanisms of the anti-atherosclerotic effects of eicosapentaenoic acid: possible role for endocannabinoids? Robert Gordon University, PhD thesis.

The ω-3 polyunsaturated fatty acids (ω-3 PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to have cardioprotective and antiatherosclerotic actions. While it has been proposed that ω-3 PUFAs may structurally stabi... Read More about Studies to determine the mechanisms of the anti-atherosclerotic effects of eicosapentaenoic acid: possible role for endocannabinoids?.

Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation. (2010)
Thesis
SKENE, K.E. 2010. Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation. Robert Gordon University, PhD thesis.

Neointimal formation is a complex process that occurs due to the over compensatory healing response produced by the vessel following injury. Three key events, SMC proliferation, SMC migration and the inflammatory response, occur in unison to drive th... Read More about Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation..

Cellular mechanisms of acute hypoxic pulmonary vasoconstriction in intrapulmonary veins. (2009)
Thesis
DOSPINESCU, C. 2009. Cellular mechanisms of acute hypoxic pulmonary vasoconstriction in intrapulmonary veins. Robert Gordon University, PhD thesis.

In the pulmonary circulation, alveolar hypoxia contributes to blood flow regulation. Hypoxic pulmonary vasoconstriction (HPV) involves both pulmonary arteries and veins, but little is known of the contractile mechanisms specific to the veins. The aim... Read More about Cellular mechanisms of acute hypoxic pulmonary vasoconstriction in intrapulmonary veins..

The nitric oxide-donating pravastatin derivative, NCX 6550 [(1S-[1α(βS*,δS*),2α,6α,8β- (R*),8aα]]-1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8- (2-methyl-1-oxobutoxy)-1-naphtalene-heptanoic acid 4-(nitrooxy)butyl ester), reduces splenocyte adhesion and reactive oxygen species generation in normal and atherosclerotic mice. (2007)
Journal Article
DEVER, G., SPICKETT, C.M., KENNEDY, S., RUSH, C., TENNANT, G., MONOPOLI, A. and WAINWRIGHT, C.L. 2007. The nitric oxide-donating pravastatin derivative, NCX 6550 [(1S-[1α(βS*,δS*),2α,6α,8β- (R*),8aα]]-1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8- (2-methyl-1-oxobutoxy)-1-naphtalene-heptanoic acid 4-(nitrooxy)butyl ester), reduces splenocyte adhesion and reactive oxygen species generation in normal and atherosclerotic mice. Journal of pharmacology and experimental therapeutics [online], 320(1), pages 419-426. Available from: https://doi.org/10.1124/jpet.106.109298

Statins possess anti-inflammatory effects that may contribute to their ability to slow atherogenesis, whereas nitric oxide (NO) also influences inflammatory cell adhesion. This study aimed to determine whether a novel NO-donating pravastatin derivati... Read More about The nitric oxide-donating pravastatin derivative, NCX 6550 [(1S-[1α(βS*,δS*),2α,6α,8β- (R*),8aα]]-1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8- (2-methyl-1-oxobutoxy)-1-naphtalene-heptanoic acid 4-(nitrooxy)butyl ester), reduces splenocyte adhesion and reactive oxygen species generation in normal and atherosclerotic mice..

Fatty acid and phospholipid chlorohydrins cause cell stress and endothelial adhesion. (2006)
Journal Article
DEVER, G., WAINWRIGHT, C. L., KENNEDY, S. and SPICKETT, C. M. 2006. Fatty acid and phospholipid chlorohydrins cause cell stress and endothelial adhesion. Acta biochimica polonica [online], 53(4), pages 761-768. Available from: https://doi.org/10.18388/abp.2006_3304

The oxidation of low-density lipoprotein (LDL) is thought to contribute to atherogenesis, which is an inflammatory disease involving activation of phagocytic cells. Myeloperoxidase, an enzyme which is able to produce hypochlorous acid (HOCl), is rele... Read More about Fatty acid and phospholipid chlorohydrins cause cell stress and endothelial adhesion..

The effect of NCX4016 [2-acetoxy-benzoate 2-(2-nitroxymethyl)-phenyl ester] on the consequences of ischemia and reperfusion in the streptozotocin diabetic rat. (2005)
Journal Article
BURKE, S.G., WAINWRIGHT, C.L., VOJNOVIC, I., WARNER, T., WATSON, D.G. and FURMAN, B.L. 2006. The effect of NCX4016 [2-acetoxy-benzoate 2-(2-nitroxymethyl)-phenyl ester] on the consequences of ischemia and reperfusion in the streptozotocin diabetic rat. Journal of pharmacology and experimental therapeutics [online], 316(3), pages 1107-1114. Available from: https://doi.org/10.1124/jpet.105.096339

The aim of this study was to assess the effect of chronic administration of NCX4016 [2 acetoxy-benzoate 2-(2-nitroxymethyl)-phenyl ester], a nitric oxide-releasing aspirin derivative on the consequences of coronary artery occlusion in streptozotocin-... Read More about The effect of NCX4016 [2-acetoxy-benzoate 2-(2-nitroxymethyl)-phenyl ester] on the consequences of ischemia and reperfusion in the streptozotocin diabetic rat..