Skip to main content

Research Repository

Advanced Search

Serum relaxin levels affect the in vivo properties of some but not all tendons in normally menstruating young women: female tendons and hormone levels.

Pearson, S. J.; Burgess, K. E.; Onambélé, G. L.

Authors

S. J. Pearson

G. L. Onambélé



Abstract

Relaxin (hRLX) is a hormone reported to affect collagen synthesis. Its effects are also thought to be modulated by other sex hormones, including oestrogen, which has previously been found to be associated with alterations of in vivo tendon properties. There is thus a potential for hRLX to impact on collagen, which could result in tendon structural and mechanical properties being modified. The present study therefore aimed to determine any interaction between hRLX and tendon stiffness, in normally menstruating women (n= 12). Tendon properties were determined using a combination of dynamometry and B-mode ultrasound, whilst serum hRLX levels were established by ELISA. Serum hRLX level was seen to be negatively associated with patellar tendon stiffness (r=-0.56;P< 0.001), explaining 31% of the variance in this parameter. There was no association between hRLX and gastrocnemius tendon stiffness (P> 0.05), or with the cross-sectional area of either of the two tendons (P> 0.05). In young, normally menstruating women, hRLX appears to have a significant effect on the patellar but not the gastrocnemius tendon stiffness. Where it has an effect, this appears to be on the intrinsic properties rather than on the dimensions of said tendon. Future work to elucidate the physiological cause of this selectivity in the impact of relaxin will be key to mapping the impact of the endocrine system on the phenotype of tendinous tissue.

Citation

PEARSON, S.J., BURGESS, K.E. and ONAMBÉLÉ, G.L. 2011. Serum relaxin levels affect the in vivo properties of some but not all tendons in normally menstruating young women. Experimental physiology [online], 96(7), pages 681-688. Available from: https://doi.org/10.1113/expphysiol.2011.057877

Journal Article Type Article
Acceptance Date Apr 8, 2011
Online Publication Date Jun 21, 2011
Publication Date Jul 31, 2011
Deposit Date Sep 4, 2023
Publicly Available Date Dec 8, 2023
Journal Experimental physiology
Print ISSN 0958-0670
Electronic ISSN 1469-445X
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 96
Issue 7
Pages 681-688
DOI https://doi.org/10.1113/expphysiol.2011.057877
Keywords Hormones; Collagen synthesis; Sex hormones; Oestrogen; Menstruating women;
Public URL https://rgu-repository.worktribe.com/output/2060308

Files

PEARSON 2011 Serum relaxin levels affect (AAM) (793 Kb)
PDF

Publisher Licence URL
https://creativecommons.org/licenses/by-nc/4.0/

Copyright Statement
This is the peer reviewed version of the following article: PEARSON, S.J., BURGESS, K.E. and ONAMBÉLÉ, G.L. 2011. Serum relaxin levels affect the in vivo properties of some but not all tendons in normally menstruating young women. Experimental physiology, 96(7), pages 681-688, which has been published in final form at https://doi.org/10.1113/expphysiol.2011.057877. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.





You might also like



Downloadable Citations