Characterisation of a novel thrombomodulin c.1487delC,p.(Pro496Argfs*10) variant and evaluation of therapeutic strategies to manage the rare bleeding phenotype.

Morrow, Gael B.; Beavis, James; Harper, Sarah; Bignell, Patricia; Laffan, Mike A.; Curry, Nicola

doi:10.1016/j.thromres.2020.11.002

Public perceptions and experiences of the minor ailment service in community pharmacy in Scotland. (2021)
Journal Article
BOAG, L., MACLURE, K., BOYTER, A., CUNNINGHAM, S., AKRAM, G., MCQUILLAN, H. and STEWART, D. 2021. Public perceptions and experiences of the minor ailment service in community pharmacy in Scotland. Pharmacy practice [online], 19(1), article 2152. Available from: https://doi.org/10.18549/pharmpract.2021.1.2152

The Minor Ailment Service (MAS) in Scottish community pharmacy allows eligible people to gain improved access to care by providing free treatment for self-limiting conditions. To determine the perceptions and experiences of individuals using MAS and... Read More about Public perceptions and experiences of the minor ailment service in community pharmacy in Scotland..

Metformin and asarone inhibit HepG2 cell proliferation in a high glucose environment by regulating AMPK and Akt signaling pathway. (2021)
Journal Article
DAS, B.K., KNOTT, R.M. and GADAD, P.C. 2021. Metformin and asarone inhibit HepG2 cell proliferation in a high glucose environment by regulating AMPK and Akt signaling pathway. Future journal of pharmaceutical sciences [online], 7, article 43. Available from: https://doi.org/10.1186/s43094-021-00193-8

Metabolic dysregulation is one of the hallmarks of tumor cell proliferation. Evidence indicates the potential role of the 5′adenosine monophosphate-activated protein kinase (AMPK) and protein kinase B/Akt signaling pathway in regulating cell prolifer... Read More about Metformin and asarone inhibit HepG2 cell proliferation in a high glucose environment by regulating AMPK and Akt signaling pathway..

Incidence of co-trimoxazole-induced hyperkalemia in a tertiary care hospital. (2021)
Journal Article
AL ADAWI, R.M., ALBU-MAHMOOD, Z., ABDELGELIL, M., ABDELAZIZ, H., STEWART, D. and AWAISU, A. 2021. Incidence of co-trimoxazole-induced hyperkalemia in a tertiary care hospital. Risk management and healthcare policy [online], 14, pages 519-525. Available from: https://doi.org/10.2147/RMHP.S283471

Co-trimoxazole is a broad-spectrum antibiotic associated with hyperkalemia. To determine the incidence of hyperkalemia and its risk factors in patients receiving co-trimoxazole. A retrospective observational study involving all patients who received... Read More about Incidence of co-trimoxazole-induced hyperkalemia in a tertiary care hospital..

Comparative metabologenomics analysis of polar actinomycetes. (2021)
Journal Article
SOLDATOU, S., ELDJÁRN, G.H., RAMSAY, A., VAN DER HOOFT, J.J.J., HUGHES, A.H., ROGERS, S. and DUNCAN, K.R. 2021. Comparative metabologenomics analysis of polar actinomycetes. Marine drugs [online], 19(2), article 103. Available from: https://doi.org/10.3390/md19020103

Biosynthetic and chemical datasets are the two major pillars for microbial drug discovery in the omics era. Despite the advancement of analysis tools and platforms for multi-strain metabolomics and genomics, linking these information sources remains... Read More about Comparative metabologenomics analysis of polar actinomycetes..

Photoelectrochemical applications of electrochemical deposition of Ni2+-doped FeS2 thin films. (2021)
Journal Article
PRABUKANTHAN, P., SREEDHAR, M., THAMARAISELVI, S., HARICHANDRAN, G., SEENUVASAKUMARAN, P., HANAFIAH, M.M. and FERNANDEZ, C. 2021. Photoelectrochemical applications of electrochemical deposition of Ni2+-doped FeS2 thin films. Journal of materials science: materials in electronics [online], 32(5), pages 6331-6343. Available from: https://doi.org/10.1007/s10854-021-05350-6

Different concentration (1–5 mol%) of Ni2+-doped FeS2 thin films were deposited by facile ECD technique. XRD pattern Ni2+ ion-doped FeS2 thin films were cubic structure with the high intensity plane (2 0 0). HRSEM images show that the undoped with 1–... Read More about Photoelectrochemical applications of electrochemical deposition of Ni2+-doped FeS2 thin films..

Hazardous cyanobacteria integrity response to velocity gradient and powdered activated carbon in water treatment plants. (2021)
Journal Article
OLIVEIRA, S., CLEMENTE, A., MENEZES, I., GOIS, A., CARLOTO, I., LAWTON, L. and CAPELO-NETO, J. 2021. Hazardous cyanobacteria integrity response to velocity gradient and powdered activated carbon in water treatment plants. Science of the total environment [online], 773, article ID 145110. Available from: https://doi.org/10.1016/j.scitotenv.2021.145110

Although some studies have investigated the impact caused by chemicals used on water treatment (coagulants and oxidants) on cyanobacteria integrity, the isolated effect of shear stress during coagulation is still not fully understood. This study eval... Read More about Hazardous cyanobacteria integrity response to velocity gradient and powdered activated carbon in water treatment plants..

Rapid analytical methods for the microalgal and cyanobacterial biorefinery: application on strains of industrial importance. (2021)
Journal Article
PALMER, J.S., LAWTON, L.A., KINDT, R. and EDWARDS, C. 2021. Rapid analytical methods for the microalgal and cyanobacterial biorefinery: application on strains of industrial importance. MicrobiologyOpen [online], 10(1), article number e1156. Available from: https://doi.org/10.1002/mbo3.1156

To realise the potential of microalgae in the biorefinery context, exploitation of multiple products is necessary for profitability and for bioproduct valorisation. Appropriate analytical tools are required for growth optimisation, culture monitoring... Read More about Rapid analytical methods for the microalgal and cyanobacterial biorefinery: application on strains of industrial importance..

Clinical benefits and costs of an outpatient parenteral antimicrobial therapy service. (2021)
Journal Article
BUGEJA, S.J., STEWART, D. and VOSPER, H. 2021. Clinical benefits and costs of an outpatient parenteral antimicrobial therapy service. Research in social and administrative pharmacy [online], 17(10), pages 1758-1763. Available from: https://doi.org/10.1016/j.sapharm.2021.01.009

Background: The enrolment of patients to an outpatient parenteral antimicrobial therapy (OPAT) service can be a means of mitigating financial burdens related to the provision of care and optimisation of hospital bed management. Objective: This study... Read More about Clinical benefits and costs of an outpatient parenteral antimicrobial therapy service..

A review of lifestyle and environment risk factors for pancreatic cancer. (2021)
Journal Article
ZANINI, S., RENZI, S., LIMONGI, A.R., BELLAVITE, P., GIOVINAZZO, F. and BERMANO, G. 2021. A review of lifestyle and environment risk factors for pancreatic cancer. European journal of cancer [online], 145, pages 53-70. Available from: https://doi.org/10.1016/j.ejca.2020.11.040

Pancreatic cancer (PaCa) is one of the deadliest cancers known and its incidence is increasing in the developed countries. Because of the lack of biomarkers that allow early detection and the tendency of the disease to be asymptomatic, the diagnosis... Read More about A review of lifestyle and environment risk factors for pancreatic cancer..

Effect of vacuum cooking process conditions on color, textural, microstructural and sensory properties of beef. (2020)
Journal Article
DEVSEREN, E., OKUT, D., KOÇ, M., KARATAŞ, H. and KAYMAK-ERTEKIN, F. 2020. Effect of vacuum cooking process conditions on color, textural, microstructural and sensory properties of beef. Akademik gida [online], 18(4), pages 347-356. Available from: https://doi.org/0.24323/akademik-gida.850826

In this study, the effect of vacuum cooking conditions (temperature and time) on the color, textural, microstructural and sensory quality of beef samples was investigated. In order to determine the optimum cooking temperature (60-90ºC) and time (80-1... Read More about Effect of vacuum cooking process conditions on color, textural, microstructural and sensory properties of beef..

Rapid uptake and slow depuration: health risks following cyanotoxin accumulation in mussels? (2020)
Journal Article
CAMACHO-MUÑOZ, D., WAACK, J., TURNER, A.D., LEWIS, A.M., LAWTON, L.A. and EDWARDS, C. 2021. Rapid uptake and slow depuration: health risks following cyanotoxin accumulation in mussels? Environmental pollution [online], 271, article ID 116400. Available from: https://doi.org/10.1016/j.envpol.2020.116400

Freshwater cyanobacteria produce highly toxic secondary metabolites, which can be transported downstream by rivers and waterways into the sea. Estuarine and coastal aquaculture sites exposed to toxic cyanobacteria raise concerns that shellfish may ac... Read More about Rapid uptake and slow depuration: health risks following cyanotoxin accumulation in mussels?.

Impact of rapeseed pomace extract on markers of oxidative stress and DNA damage in human SH‐SY5Y cells. (2020)
Journal Article
POHL, F., GOUA, M., YATES, K., BERMANO, G., RUSSELL, W.R., MACIEL, P. and KONG THOO LIN, P. 2021. Impact of rapeseed pomace extract on markers of oxidative stress and DNA damage in human SH‐SY5Y cells. Journal of food biochemistry [online], 45(2), article e13592. Available from: https://doi.org/10.1111/jfbc.13592

With increased longevity and subsequent rise in people with age-related neurodegenerative diseases, protection of neurons from oxidative stress damage has become an important field of study. For the first time, we highlight the neuroprotective proper... Read More about Impact of rapeseed pomace extract on markers of oxidative stress and DNA damage in human SH‐SY5Y cells..

A state-of-charge estimation method of the power lithium-ion battery in complex conditions based on adaptive square root extended Kalman filter. (2020)
Journal Article
JIANG, C., WANG, S., WU, B., FERNANDEZ, C., XIONG, X. and COFFIE-KEN, J. 2021. A state-of-charge estimation method of the power lithium-ion battery in complex conditions based on adaptive square root extended Kalman filter. Energy [online], 219, article ID 119603. Available from: https://doi.org/10.1016/j.energy.2020.119603

The control strategy of electric vehicles mainly depends on the power battery state-of-charge estimation. One of the most important issues is the power lithium-ion battery state-of-charge (SOC) estimation. Compare with the extended Kalman filter algo... Read More about A state-of-charge estimation method of the power lithium-ion battery in complex conditions based on adaptive square root extended Kalman filter..

Análise de dados categóricos de integridade celular de cianobactérias. (2020)
Journal Article
CLEMENTE, A., OLIVEIRA, S., MENEZES, I., CARLOTO, I. and CAPELO NETO, J. 2021. Análise de dados categóricos de integridade celular de cianobactérias. Revista DAE [online], 69(228), pages 205-224. Available from: https://doi.org/10.36659/dae.2021.015

The techniques used in cyanobacterial cell integrity/viability studies provide two outcomes: intact cells or not. These categorical and dichotomous values often make statistical analysis of the results difficult. In this context, the aim of this pape... Read More about Análise de dados categóricos de integridade celular de cianobactérias..

The power state estimation method for high energy ternary lithium-ion batteries based on the online collaborative equivalent modeling and adaptive correction-unscented Kalman filter. (2020)
Journal Article
FAN, Y., WANG, S., JIANG, C. and FERNANDEZ, C. 2021. The power state estimation method for high energy ternary lithium-ion batteries based on the online collaborative equivalent modeling and adaptive correction-unscented Kalman filter. International journal of electrochemical science [online], 16(1), article ID 151020. Available from: https://doi.org/10.20964/2021.01.70

Accurate power state estimation plays an important role in the real-time working state monitoring and safety control of high energy lithium-ion batteries. To solve the difficulty and low accuracy problems in its real-time power state estimation under... Read More about The power state estimation method for high energy ternary lithium-ion batteries based on the online collaborative equivalent modeling and adaptive correction-unscented Kalman filter..

Anatoxin-a degradation by using titanium dioxide. (2020)
Journal Article
KAMINSKI, A., EDWARDS, C., CHRAPUSTA-SREBRNY, E. and LAWTON, L.A. 2021. Anatoxin-a degradation by using titanium dioxide. Science of the total environment [online], 756, article ID 143590. Available from: https://doi.org/10.1016/j.scitotenv.2020.143590

Advanced oxidation processes, such as using titanium dioxide (TiO2) photocatalysis, are being developed to reduce or eliminate the toxicity of treated water. In this study, the removal of purified anatoxin-a (ANTX-a), live Dolichospermum flos-aquae c... Read More about Anatoxin-a degradation by using titanium dioxide..

Theranostic approach for the protein corona of polysaccharide nanoparticles. (2020)
Journal Article
SKALICKOVA, S., HORKY, P., MLEJNKOVA, V., SKLADANDA, J., HOSNEDLOVA, B., RUTTKAY-NEDECKY, B., FERNANDEZ, C. and KIZEK, R. 2021. Theranostic approach for the protein corona of polysaccharide nanoparticles. Chemical record [online], 21(1), pages 17-28. Available from: https://doi.org/10.1002/tcr.202000042

Polysaccharide nanoparticles are promising materials in the wide range of disciplines such as medicine, nutrition, food production, agriculture, material science and others. They excel- not only in their non-toxicity and biodegradability but also in... Read More about Theranostic approach for the protein corona of polysaccharide nanoparticles..

mTOR pathway in gastroenteropancreatic neuroendocrine tumor (GEP-NETs). (2020)
Journal Article
ZANINI, S., RENZI, S., GIOVINAZZO, F. and BERMANO, G. 2020. mTOR pathway in gastroenteropancreatic neuroendocrine tumor (GEP-NETs). Frontiers in endocrinology [online], 11, article ID 562505. Available from: https://doi.org/10.3389/fendo.2020.562505

Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) originate from neuroendocrine cells in the gastrointestinal tract. They are heterogeneous, and though initially considered rare tumors, the incidence of GEP-NENs has increased in the last few... Read More about mTOR pathway in gastroenteropancreatic neuroendocrine tumor (GEP-NETs)..

Cut-lengths of perennial ryegrass leaf-blades influences in vitro fermentation by the anaerobic fungus neocallimastix frontalis. (2020)
Journal Article
JIMENEZ, H.R., EDWARDS, J.E., SANDERSON, R., KINGSTON-SMITH, A.H., MCEWAN, N.R. and THEODOROU, M.K. 2020. Cut-lengths of perennial ryegrass leaf-blades influences in vitro fermentation by the anaerobic fungus neocallimastix frontalis. Microorganisms [online], 8(11): unleashing the hidden potential of anaerobic fungi, article ID 1774. Available from: https://doi.org/10.3390/microorganisms8111774

Anaerobic fungi in the gut of domesticated and wild mammalian herbivores play a key role in the host’s ability to utilize plant biomass. Due to their highly effective ability to enzymatically degrade lignocellulose, anaerobic fungi are biotechnologic... Read More about Cut-lengths of perennial ryegrass leaf-blades influences in vitro fermentation by the anaerobic fungus neocallimastix frontalis..

Characterisation of a novel thrombomodulin c.1487delC,p.(Pro496Argfs*10) variant and evaluation of therapeutic strategies to manage the rare bleeding phenotype. (2020)
Journal Article
MORROW, G.B., BEAVIS, J., HARPER, S., BIGNELL, P., LAFFAN, M.A. and CURRY, N. 2021. Characterisation of a novel thrombomodulin c.1487delC,p.(Pro496Argfs*10) variant and evaluation of therapeutic strategies to manage the rare bleeding phenotype. Thrombosis research [online], 197, pages 100-108. Available from: https://doi.org/10.1016/j.thromres.2020.11.002

A novel variant in the thrombomodulin (TM) gene, c.1487delC,p.(Pro496Argfs*10), referred to as Pro496Argfs*10, was identified in a family with an unexplained bleeding disorder. The Pro496Argfs*10 variant results in loss of the transmembrane and intra... Read More about Characterisation of a novel thrombomodulin c.1487delC,p.(Pro496Argfs*10) variant and evaluation of therapeutic strategies to manage the rare bleeding phenotype..

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