Evaluation of new naphthalimides as potential anticancer agents against breast cancer MCF-7, pancreatic cancer BxPC-3 and colon cancer HCT-15 cell lines.

Noro, J.; Maciel, J.; Duarte, D.; Olival, A.C.D.; Baptista, C.; Silva, A.C.D.; Alves, M.J.; Kong Thoo Lin, P.

doi:10.4172/2161-0401.1000144

Simultaneous cellulose conversion and hydrogen production assisted by cellulose decomposition under UV-light photcatalysis. (2015)
Journal Article
ZHANG, G., NI, C., HUANG, X., WELGARMAGE, A., LAWTON, L.A., ROBERTSON, P.K.J. and IRVINE, J.T.S. 2016. Simultaneous cellulose conversion and hydrogen production assisted by cellulose decomposition under UV-light photcatalysis. Chemical communications [online], 52, pages 1673-1676. Available from: https://doi.org/10.1039/c5cc09075j

Photocatalytic conversion of cellulose to sugars and carbon dioxide with simultaneous production of hydrogen assisted by cellulose decomposition under UV or solar light irradiation was achieved upon immobilization of cellulose onto a TiO2 photocataly... Read More about Simultaneous cellulose conversion and hydrogen production assisted by cellulose decomposition under UV-light photcatalysis..

The role of ciliate protozoa in the rumen. (2015)
Journal Article
NEWBOLD, C.J., DE LA FUENTE, G. BELANCHE, A. RAMOS-MORALES, E. and MCEWAN, N.R. 2015. The role of ciliate protozoa in the rumen. Frontiers in microbiology [online], 6, Article 1313. Available from: https://doi.org/10.3389/fmicb.2015.01313

First described in 1843, Rumen protozoa with their striking appearance were assumed to be important for the welfare of their host. However, despite contributing up to 50% of the bio-mass in the rumen, the role of protozoa in rumen microbial ecosystem... Read More about The role of ciliate protozoa in the rumen..

Microneedle coating techniques for transdermal drug delivery. (2015)
Journal Article
HAJ-AHMAD, R., KHAN, H., ARSHAD, M.S., RASEKH, M., HUSSAIN, A., WALSH, S., LI, X., CHANG, M.-W. and AHMAD, Z. 2015. Microneedle coating techniques for transdermal drug delivery. Pharmaceutics [online], 7(4), pages 486-502. Available from: https://doi.org/10.3390/pharmaceutics7040486

Drug administration via the transdermal route is an evolving field that provides an alternative to oral and parenteral routes of therapy. Several microneedle (MN) based approaches have been developed. Among these, coated MNs (typically where drug is... Read More about Microneedle coating techniques for transdermal drug delivery..

Assessment of tigecycline prescription and patients' outcomes at three different hospitals in Saudi Arabia. (2015)
Journal Article
TOBAIQY, M., AL HUMAID, S., STEWART, D., ALOTAIBI, F.O., QURESHI, K.A., MACLURE, K., ALGHARIB, F., ALSMETI, A., ALSAQER, A. and ALMEMAN, A. 2015. Assessment of tigecycline prescription and patients' outcomes at three different hospitals in Saudi Arabia. Tropical journal of pharmaceutical research [online], 14(10), pages 1919-1926. Available from: https://doi.org/10.4314/tjpr.v14i10.26

The purpose of this study is to investigate tigecycline prescription and patient outcomes in the Kingdom of Saudi Arabia (KSA). A retrospective observational study was conducted in three KSA government hospitals, between January, 2013 and May, 2014.... Read More about Assessment of tigecycline prescription and patients' outcomes at three different hospitals in Saudi Arabia..

The use of theory in research. (2015)
Journal Article
STEWART, D. and KLEIN, S. 2016. The use of theory in research. International journal of clinical pharmacy [online], 38(3), pages 615-619. Available from: https://doi.org/10.1007/s11096-015-0216-y

All researchers should consider the theoretical basis for their studies very early on in the planning stage. The aim of this paper is to describe and discuss how theory (a 'comprehensive explanation of some aspect of nature that is supported by a bod... Read More about The use of theory in research..

An exploration of health professionals' experiences of medicines management in elderly, hospitalised patients in Abu Dhabi. (2015)
Journal Article
AL SHEMEILI, S., KLEIN, S., STRATH, A., FARES, S. and STEWART, D. 2016. An exploration of health professionals' experiences of medicines management in elderly, hospitalised patients in Abu Dhabi. International journal of clinical pharmacy [online], 38(1), pages 107-118. Available from: https://doi.org/10.1007/s11096-015-0212-2

Background Given the multiplicity of issues relating to medicines in the elderly, the structures and processes of medicines management should be clearly defined and described to optimise patient outcomes. There is a paucity of research which provides... Read More about An exploration of health professionals' experiences of medicines management in elderly, hospitalised patients in Abu Dhabi..

Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression. (2015)
Journal Article
BARRON, G.A., GOUA, M., KURAOKA, I., BERMANO, G., IWAI, S. and KONG THOO LIN, P. 2015. Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression. Chemico-biological interactions [online], 242, pages 307-315. Available from: https://doi.org/10.1016/j.cbi.2015.10.017

Bisnaphthalimidopropyl diaminodicyclohexylmethane (BNIPDaCHM) bisintercalates to DNA and is a potential anti-cancer therapeutic. In an attempt to elucidate the mechanism(s) underlying the potential of BNIPDaCHM; earlier work was extended to investiga... Read More about Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression..

Self-reported digital literacy of the pharmacy workforce in North East Scotland. (2015)
Journal Article
MACLURE, K. and STEWART, D. 2015. Self-reported digital literacy of the pharmacy workforce in North East Scotland. Pharmacy [online], 3(4), pages 182-196. Available from: https://doi.org/10.3390/pharmacy3040182

In their day-to-day practice, pharmacists, graduate (pre-registration) pharmacists, pharmacy technicians, dispensing assistants and medicines counter assistants use widely available office, retail and management information systems alongside dedicate... Read More about Self-reported digital literacy of the pharmacy workforce in North East Scotland..

Weight loss for women with and without polycystic ovary syndrome following a very low-calorie diet in a community-based setting with trained facilitators for 12 weeks. (2015)
Journal Article
NIKOKAVOURA, E.A., JOHNSTON, K.L., BROOM, J., WRIEDEN.W.L. and ROLLAND, C. 2015. Weight loss for women with and without polycystic ovary syndrome following a very low-calorie diet in a community-based setting with trained facilitators for 12 weeks. Diabetes, metabolic syndrome and obesity: targets and therapy [online], 8, pages 495-503. Available from: https://doi.org/10.2147/DMSO.S85134

Background: Polycystic ovary syndrome (PCOS) affects between 2% and 26% of reproductive-age women in the UK, and accounts for up to 75% of anovulatory infertility. The major symptoms include ovarian disruption, hyperandrogenism, insulin resistance, a... Read More about Weight loss for women with and without polycystic ovary syndrome following a very low-calorie diet in a community-based setting with trained facilitators for 12 weeks..

A qualitative study of UK pharmacy pre-registration graduates' views and reflections on pharmacist prescribing. (2015)
Journal Article
MCINTOSH, T. and STEWART, D. 2016. A qualitative study of UK pharmacy pre-registration graduates' views and reflections on pharmacist prescribing. International journal of pharmacy practice [online], 24(2), pages 139-141. Available from: https://doi.org/10.1111/ijpp.12222

Background: Pre-registration pharmacy graduates are a key group in relation to developing and implementing innovations in practice. Objective: To explore the views and reflections on pharmacist prescribing of UK pre-registration pharmacy graduates. M... Read More about A qualitative study of UK pharmacy pre-registration graduates' views and reflections on pharmacist prescribing..

Rapid bioassay-guided isolation of antibacterial clerodane type diterpenoid from Dodonaea viscosa (L.) Jaeq. (2015)
Journal Article
KHURRAM, M., LAWTON, L.A., EDWARDS, C., IRITI, M., HAMEED, A., KHAN, M.A., KHAN, F.A. and RAHMAN, S.U. 2015. Rapid bioassay-guided isolation of antibacterial clerodane type diterpenoid from Dodonaea viscosa (L.) Jaeq. International journal of molecular science [online], 16(9), pages 20290-20307. Available from: https://doi.org/10.3390/ijms160920290

Plant extracts are complex matrices and, although crude extracts are widely in use, purified compounds are pivotal in drug discovery. This study describes the application of automated preparative-HPLC combined with a rapid off-line bacterial bioassay... Read More about Rapid bioassay-guided isolation of antibacterial clerodane type diterpenoid from Dodonaea viscosa (L.) Jaeq..

A preliminary investigation to group disparate batches of licit and illicit diazepam tablets using differential scanning calorimetry. (2015)
Journal Article
BIBI, S., BREMNER, D.H., MACDOUGALL-HEASMAN, M., REID, R., SIMPSON, K., TOUGH, A., WADDELL, S., STEWART, I.J. and MATTHEWS, K.H. 2015. A preliminary investigation to group disparate batches of licit and illicit diazepam tablets using differential scanning calorimetry. Analytical methods [online], 7(20), pages 8597-8604. Available from: https://doi.org/10.1039/C5AY01711D

Increasing numbers of illicit and unlicensed medicines are in general circulation and regularly seized by the police and other regulatory authorities. Forensic identification of seized tablets tends to focus on visual appearance and chromatographic i... Read More about A preliminary investigation to group disparate batches of licit and illicit diazepam tablets using differential scanning calorimetry..

Support for community pharmacy-based alcohol interventions: a Scottish general public survey. (2015)
Journal Article
FITZGERALD, N., YOUNGSON, E., CUNNINGHAM, S., WATSON, M. and STEWART, D. 2015. Support for community pharmacy-based alcohol interventions: a Scottish general public survey. Public health [online], 129(11), pages 1431-1438. Available from: https://doi.org/10.1016/j.puhe.2015.07.005

Background: Community pharmacy teams are recognised by health agencies as vital to increasing capacity in the provision of public health services. Public awareness and support of these services in general, and relating to safe alcohol consumption in... Read More about Support for community pharmacy-based alcohol interventions: a Scottish general public survey..

Aerobic interval exercise improves parameters of Non Alcoholic Fatty Liver Disease (NAFLD) and other alterations of metabolic syndrome in obese Zucker rats. (2015)
Journal Article
KAPRAVELOU, G., MARTINEZ, R., ANDRADE, A.M., NEBOT, E., CAMILETTI-MOIRON, D., APARICIO, V.A., LOPEZ-JURADO, M., ARANDA, P., ARREBOLA, F., FERNANDEZ-SEGURA, E., BERMANO, G., GOUA, M., GALISTEO, M. and PORRES, J.M. 2015. Aerobic interval exercise improves parameters of Non Alcoholic Fatty Liver Disease (NAFLD) and other alterations of metabolic syndrome in obese Zucker rats. Applied physiology, nutrition and metabolism [online], 40(12), pages 1242-1252. Available from: https://doi.org/10.1139/apnm-2015-0141

Metabolic syndrome (MS) is a group of metabolic alterations that increase the susceptibility to cardiovascular disease and type 2 diabetes. Nonalcoholic fatty liver disease has been described as the liver manifestation of MS. We aimed to test the ben... Read More about Aerobic interval exercise improves parameters of Non Alcoholic Fatty Liver Disease (NAFLD) and other alterations of metabolic syndrome in obese Zucker rats..

Healthcare professionals' perceptions of the facilitators and barriers to implementing electronic systems for the prescribing, dispensing and administration of medicines in hospitals: a systematic review. (2015)
Journal Article
HOGAN-MURPHY, D., TONNA, A., STRATH, A. and CUNNINGHAM, S. 2015. Healthcare professionals' perceptions of the facilitators and barriers to implementing electronic systems for the prescribing, dispensing and administration of medicines in hospitals: a systematic review. European journal of hospital pharmacy [online], 22(6), pages 358-365. Available from: https://doi.org/10.1136/ejhpharm-2015-000722

Abstract Objective To identify, critically appraise, synthesise and present the available evidence on healthcare professionals' perceptions of the facilitators and barriers to implementing electronic prescribing, dispensing and/or administration of m... Read More about Healthcare professionals' perceptions of the facilitators and barriers to implementing electronic systems for the prescribing, dispensing and administration of medicines in hospitals: a systematic review..

Evaluation of the practice of veterinary pharmacy. (2015)
Journal Article
O'DRISCOLL, N.H., LABOVITIADI, O. and LAMB, A.J. 2015. Evaluation of the practice of veterinary pharmacy. Currents in pharmacy teaching and learning [online], 7(5), pages 606-613. Available from: https://doi.org/10.1016/j.cptl.2015.06.017

Background: In the United Kingdom (UK), pharmacists' roles have expanded considerably in recent decades to encompass clinical practice through more direct patient care. However, dispensing and compounding remain core activities for pharmacists. A lac... Read More about Evaluation of the practice of veterinary pharmacy..

Food and drink purchasing habits out of school at lunchtime: a national survey of secondary school pupils in Scotland. (2015)
Journal Article
MACDIARMID, J.I., WILLS, W.J., MASSON, L.F., CRAIG, L.C.A., BROMLEY, C. and MCNEILL, G. 2015. Food and drink purchasing habits out of school at lunchtime: a national survey of secondary school pupils in Scotland. International of behavioural nutrition and physical activity [online], 12, article ID 98. Available from: https://doi.org/10.1186/s12966-015-0259-4

Background: Food and drink purchasing habits of pupils out of school at lunchtime may be contributing to poor dietary intakes and overweight and obesity. The aim of this study was to identify the places from which purchases were made, types of food a... Read More about Food and drink purchasing habits out of school at lunchtime: a national survey of secondary school pupils in Scotland..

Comparative genetic diversity in a sample of pony breeds from the U.K. and North America: a case study in the conservation of global genetic resources. (2015)
Journal Article
WINTON, C.L., PLANTE, Y., HIND, P., MCMAHON, R., HEGARTY, M.J., MCEWAN, N.R., DAVIES-MOREL, M.C.G., MORGAN, C.M., POWELL, W. and NASH, D.M. 2015. Comparative genetic diversity in a sample of pony breeds from the U.K. and North America: a case study in the conservation of global genetic resources. Ecology and evolution [online], 5(16), pages 3507-3522. Available from: https://doi.org/10.1002/ece3.1562

Most species exist as subdivided ex situ daughter population(s) derived from a single original group of individuals. Such subdivision occurs for many reasons both natural and manmade. Traditional British and Irish pony breeds were introduced to North... Read More about Comparative genetic diversity in a sample of pony breeds from the U.K. and North America: a case study in the conservation of global genetic resources..

Pharmaceutical electrochemistry: the electrochemical oxidation of paracetamol and its voltammetric sensing in biological samples based on screen printed graphene electrodes. (2015)
Journal Article
FERNANDEZ, C., HEGER, Z., KIZEK, R., RAMAKRISHNAPPA, T., BORUN, A. and FAISAL, N.H. 2015. Pharmaceutical electrochemistry: the electrochemical oxidation of paracetamol and its voltammetric sensing in biological samples based on screen printed graphene electrodes. International journal of electrochemical science [online], 10(9), pages 7440-7452. Available from: https://doi.org/10.1016/S1452-3981(23)17361-5

We present a sensitive, fast and unmodified sensor for the electrochemical detection of paracetamol. The electrochemical behaviours of paracetamol on screen printed graphene electrodes were investigated for the first time by cyclic voltammetry. The r... Read More about Pharmaceutical electrochemistry: the electrochemical oxidation of paracetamol and its voltammetric sensing in biological samples based on screen printed graphene electrodes..

Evaluation of new naphthalimides as potential anticancer agents against breast cancer MCF-7, pancreatic cancer BxPC-3 and colon cancer HCT-15 cell lines. (2015)
Journal Article
NORO, J., MACIEL, J., DUARTE, D., OLIVAL, A.C.D., BAPTISTA, C., SILVA, A.C.D., ALVES, M.J. and KONG THOO LIN, P. 2015. Evaluation of new naphthalimides as potential anticancer agents against breast cancer MCF-7, pancreatic cancer BxPC-3 and colon cancer HCT-15 cell lines. Organic chemistry: current research [online], 4(3), ID 1000144. Available from: https://doi.org/10.4172/2161-0401.1000144

New 1,8-naphthalimido derivatives with 2,3 and 4 carbon chains bearing a number of different functionalities were synthesized and tested against a panel of breast cancer MCF-7, colon cancer HCT-15 and pancreatic cancer BxPC-3 cell lines. Generally st... Read More about Evaluation of new naphthalimides as potential anticancer agents against breast cancer MCF-7, pancreatic cancer BxPC-3 and colon cancer HCT-15 cell lines..

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