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Investigating the impact of adiposity-redox defence interaction on redox homeostasis and inflammatory and cancer-related pathways in human colonocytes

People Involved

Project Description

Colorectal cancer is the third most common cancer and the second most common cause of cancer-related death.
Increased body fat have been reported as one of the main factors responsible for the rise in colorectal cancer.
For this reason, a major focus for research, as well as public health policy, is to understand the mechanisms by which obesity impacts on cancer development and how these mechanisms can be altered to prevent or treat this condition.
In addition, obese individuals usually have reduced fruit and vegetable intake consumption and consequently low intake of micronutrients important for optimal health and regulation of antioxidant defences, such as the micronutrient selenium.
This project aims to investigate the impact of adiposity on cell metabolism, inflammation and oxidative stress in the colon.

Type of Project Project
Status Project Live
Funder(s) Academy of Medical Sciences
Value £99,000.00
Project Dates Mar 15, 2021 - Mar 14, 2023

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