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The in vitro effect of natural products and anti-cancer agents: targeting the efflux transporter ABCG2

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Project Description

Medicinal use of natural products, such as, extracts from plants have existed for many years particularly in China and are now widely available around the world. Several different types of cancer including breast cancer are becoming insensitive and resistant to the effective therapies currently available in the clinic. Transporter molecules - which play a role in drug adsorption in the intestines, at the blood brain barrier, in the liver, the kidney and other parts of the body of drugs - have been identified to be involved in multi drug resistance (MDR). Therefore, this project aims to investigate the interaction between plant extracts and clinically available anti-cancer drugs with the aim of investigating possible interactions at the level of transporter molecules. This is an important area of research as resistance of cancer cells to drugs is a major obstacle to successful and effective cancer therapy.

Type of Project Project
Status Project Complete
Funder(s) Tenovus Scotland
Value £9,800.00
Project Dates Jul 1, 2017 - Dec 31, 2019

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