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Defining the emerging roles of GPR55

People Involved

Professor Cherry Wainwright c.wainwright@rgu.ac.uk
Professor

Project Description

The G-protein coupled receptor (GPCR) superfamily play crucial roles in cell communication. Given their involvement in neurological disorders, inflammatory and metabolic diseases, diabetes and cardiac dysfunction they represent the largest and most successful class of "druggable" targets in the human body. However the function of numerous members of this family remain poorly understood, but may well represent important therapeutic targets for treatment of major public health issues, such as obesity, diabetes and cardiovascular disease.

This project aims to explore links between a lipid sensing GPCR, called GPR55, and processes influencing adiposity, inflammation, cardiac function and response to insulin within key metabolic tissues, such as white fat, liver, skeletal muscle and heart.

Collectively, our pilot studies indicate GPR55 may function as a novel metabolic regulator within tissues and suggest that understanding how it regulates insulin action, lipid metabolism and cardiac function may offer new pharmacological opportunities for treatment of metabolic disorders associated with conditions such as obesity and type II diabetes.

In partnership with University of Dundee

Status Project Live
Funder(s) Biotechnology & Biological Sciences Research Council
Value £204,620.00
Project Dates Oct 1, 2019 - Sep 30, 2021
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