Professor Giovanna Bermano g.bermano@rgu.ac.uk
Professor
Professor Giovanna Bermano g.bermano@rgu.ac.uk
Professor
Dr Sarah Walsh s.walsh@rgu.ac.uk
Research Fellow
Agroceutical Products Ltd (APL) produces sustainable quantities of the naturally derived alkaloid galanthamine from daffodils, which is a key active pharmaceutical used for the treatment of Alzheimer’s disease. Daffodils contain an abundance of other alkaloid compounds, some of which (e.g. narciclasine and haemanthamine) APL can extract alongside galanthamine. There is emerging evidence that some of these alkaloids may target cellular events in the heart cell (cardiomyocyte) to interrupt heart failure (HF) associated structural changes, and thus have the potential for development as novel therapeutics in the prevention of HF. Previous work, carried out on a Proof of concept grant from HVB, has shown that one alkaloid compound has potential. This project will involve further testing to increase the body of evidence for its potential as anti-hypertrophic/anti-fibrotic molecules, and to gain better understanding into cellular mechanism of action. Outcomes will bring added value to the company current production stream which will, in turn maximise the commercial potential for their products.
Project Acronym | HVB Follow on Fund |
---|---|
Status | Project Complete |
Funder(s) | Biotechnology & Biological Sciences Research Council |
Value | £27,501.00 |
Project Dates | Sep 1, 2023 - Apr 30, 2024 |
sFRPs as a novel modulator of diastolic heart failure Oct 1, 2017 - Dec 31, 2021
Following a heart attack, or because of persistently high blood pressure the heart is damaged and has to work harder to circulate blood around the body. This condition is known as heart failure. In the UK alone, 500,000 people have heart failure re...
Read More about sFRPs as a novel modulator of diastolic heart failure.
A human Glutathione Peroxidase 4 3 untranslated region knock-in mouse model to study susceptibility to colon cancer in obesity Apr 1, 2017 - Dec 31, 2021
Colorectal cancer (CRC) incidence is rising steadily and in parallel with increasing prevalence of obesity in Scotland. Recent data indicate that the highest incidence rates are in the North East. The increasing prevalence of obes...
Read More about A human Glutathione Peroxidase 4 3 untranslated region knock-in mouse model to study susceptibility to colon cancer in obesity.
The in vitro effect of natural products and anti-cancer agents: targeting the efflux transporter ABCG2 Jul 1, 2017 - Dec 31, 2019
Medicinal use of natural products, such as, extracts from plants have existed for many years particularly in China and are now widely available around the world. Several different types of cancer including breast cancer are becoming insensitive and r...
Read More about The in vitro effect of natural products and anti-cancer agents: targeting the efflux transporter ABCG2.
Extracting added value from the Seaweed Industry - a search for novel anti-obesity agents Oct 1, 2018 - Dec 31, 2022
Seaweed farming is a growing industry in the UK, with the majority of the biomass being used for the extraction of high yield products such as aliginates, or for use as biofuels.
However, a significant amount of the biomass remains un-used and t...
Read More about Extracting added value from the Seaweed Industry - a search for novel anti-obesity agents.
About OpenAIR@RGU
Administrator e-mail: publications@rgu.ac.uk
This application uses the following open-source libraries:
Apache License Version 2.0 (http://www.apache.org/licenses/)
Apache License Version 2.0 (http://www.apache.org/licenses/)
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2025
Advanced Search