Professor Giovanna Bermano g.bermano@rgu.ac.uk
Professor
Bioactivity of a compound derived from Amaryllidaceae (Daffodil) in a C.elegans model of obesity
People Involved
Project Description
A previous proof-of-concept study demonstrated that an alkaloid extracted from daffodil bulbs by Agroceutical Products Ltd (APL), alongside sustainable galanthamine production (alkaloid used for Alzheimer’s disease management), selectively reduced release of two important antioxidant and anti-inflammatory molecules from cells exposed to high-levels of glucose. These molecules are typically associated with obesity and metabolic syndrome and are implicated in the development of cardiovascular disease.
This project will further explore the properties of this daffodil-derived alkaloid extracted from bulbs grown by Grampian Growers Ltd (GG) and APL, using the APL extraction process, in a whole-organism model of obesity (C. elegans nematode). The information gathered will not only expand the evidence-base to support investment in the refinement of the process to isolate different alkaloids, in addition to galanthamine, but will also provide GG with the opportunity to develop a business case to expand their production stream and maximise their products’ commercial potential
| Status | Project Live |
|---|---|
| Funder(s) | Industrial Biotechnology Innovation Centre |
| Value | £9,994.00 |
| Project Dates | Sep 1, 2023 - May 30, 2024 |
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