All Outputs (21)

Corrigendum to: Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review. (2022)
Journal Article
WAINWRIGHT, C.L., TEIXEIRA, M.M., ADELSON, D.L. et al. 2022. Corrigendum to: Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review. Pharmacological research [online], 180, article 106207. Available from: https://doi.org/10.1016/j.phrs.2022.106207

During the manuscript editing three authors were omitted and the chemical structure was missing from Figure 9. This output contains the missing authors and a corrected Figure 9.

Exploring the role of Wnt signalling in heart failure with preserved ejection fraction. (2022)
Thesis
PAUL, M.A. 2022. Exploring the role of Wnt signalling in heart failure with preserved ejection fraction. Robert Gordon University, PhD thesis. Hosted on OpenAIR [online]. Available from: https://doi.org/10.48526/rgu-wt-1987960

According to the European Society of Cardiology long-term out-patient registry, heart failure with preserved ejection fraction (HFpEF) accounts for approximately 16% of heart failure cases, with survival rates failing to improve due to the lack of ef... Read More about Exploring the role of Wnt signalling in heart failure with preserved ejection fraction..

Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review. (2022)
Journal Article
WAINWRIGHT, C.L., TEIXEIRA, M.M., ADELSON, D.L. et al. 2022. Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review. Pharmacological research [online], 177, article 106076. Available from: https://doi.org/10.1016/j.phrs.2022.106076

Drug discovery from natural sources is going through a renaissance, having spent many decades in the shadow of synthetic molecule drug discovery, despite the fact that natural product-derived compounds occupy a much greater chemical space than those... Read More about Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review..

GPR55 regulates the responsiveness to, but does not dimerise with, α1A-adrenoceptors. (2021)
Journal Article
WALSH, S.K., LIPINA, C., ANG, S.Y., SATO, M., CHIA, L.Y., KOCAN, M., HUTCHINSON, D.S., SUMMERS, R.J. and WAINWRIGHT, C.L. 2021. GPR55 regulates the responsiveness to, but does not dimerise with, α1A-adrenoceptors. Biochemical pharmacology [online], 188, article ID 114560. Available from: https://doi.org/10.1016/j.bcp.2021.114560

Emerging evidence suggests that G protein coupled receptor 55 (GPR55) may influence adrenoceptor function/activity in the cardiovascular system. Whether this reflects direct interaction (dimerization) between receptors or signalling crosstalk has not... Read More about GPR55 regulates the responsiveness to, but does not dimerise with, α1A-adrenoceptors..

Exploration of competency requirements and current training models in remote medical emergency response in the oil and gas industry of Nigeria: a mixed method study. (2020)
Thesis
OSAKWE ADAKPORIA, K.A. 2020. Exploration of competency requirements and current training models in remote medical emergency response in the oil and gas industry of Nigeria: a mixed method study. Robert Gordon University, PhD thesis. Hosted on OpenAIR [online]. Available from: https://doi.org/10.48526/rgu-wt-1447366

Medical Emergency Response (MER) in remote work locations such as the Oil and Gas (O&G) industry industry might encounter challenges with potential delay in response time and negative consequences. The aim of this study was to explore current practic... Read More about Exploration of competency requirements and current training models in remote medical emergency response in the oil and gas industry of Nigeria: a mixed method study..

Studies on the role of zinc in maintaining antioxidant status in the heart. (2020)
Thesis
OKAFOR, O.A.G. 2020. Studies on the role of zinc in maintaining antioxidant status in the heart. Robert Gordon University, MRes thesis. Hosted on OpenAIR [online]. Available from: https://openair.rgu.ac.uk

Zinc (Zn2+) is an essential micronutrient which plays a pivotal role as a signalling, catalytic and structural component in cells and functions in several physiological processes such as immune function, wound healing, cognition, reproduction and as... Read More about Studies on the role of zinc in maintaining antioxidant status in the heart..

Cannabidiol exerts species selective cardioprotective effects in anthracycline-induced cardiotoxicity. (2019)
Presentation / Conference Contribution
BARRON, G., WAINWRIGHT, C. and WALSH, S.K. 2019. Cannabidiol exerts species selective cardioprotective effects in anthracycline-induced cardiotoxicity. Presented at the 2019 Pharmacology conference, 15-17 December 2019, Edinburgh, UK.

Anthracyclines such as doxorubicin are effective chemotherapy agents, however a severe and common side effect of this treatment is anthracycline induced cardiotoxicity (AIC), which damages the heart muscle severely impacting its ability to pump and c... Read More about Cannabidiol exerts species selective cardioprotective effects in anthracycline-induced cardiotoxicity..

l-α-Lysophosphatidylinositol (LPI) aggravates myocardial ischemia/reperfusion injury via a GPR55/ROCK-dependent pathway. (2019)
Journal Article
ROBERTSON-GRAY, O.J., WALSH, S.K., RYBERG, E., JÖNSSON-RYLANDER, A.-C., LIPINA, C. and WAINWRIGHT, C.L. 2019. l‐α‐Lysophosphatidylinositol (LPI) aggravates myocardial ischemia/reperfusion injury via a GPR55/ROCK‐dependent pathway. Pharmacology research and perspectives [online], 7(3), article ID e00487. Available from: https://doi.org/10.1002/prp2.487

The phospholipid l-α-lysophosphatidylinositol (LPI), an endogenous ligand for GPR55, is elevated in patients with acute coronary syndrome, and a GPR55 antagonist cannabidiol (CBD) reduces experimental ischemia/reperfusion (I/R) injury. While LPI acti... Read More about l-α-Lysophosphatidylinositol (LPI) aggravates myocardial ischemia/reperfusion injury via a GPR55/ROCK-dependent pathway..

Acute dietary zinc deficiency in rats exacerbates myocardial ischaemia-reperfusion injury through depletion of glutathione. (2019)
Journal Article
SKENE, K., WALSH, S.K., OKAFOR, O., GODSMAN, N., BARROWS, C., MEIER, P., GORDON, M.J., BEATTIE, J.H. and WAINWRIGHT, C.L. 2019. Acute dietary zinc deficiency in rats exacerbates myocardial ischaemia-reperfusion injury through depletion of glutathione. British journal of nutrition [online], 121(9), pages 961-973. Available from: https://doi.org/10.1017/S0007114519000230

Zinc (Zn) plays an important role in maintaining the anti-oxidant status within the heart, and helps to counter the acute redox stress that occurs during myocardial ischaemia and reperfusion. Individuals with low zinc (Zn) levels are at greater risk... Read More about Acute dietary zinc deficiency in rats exacerbates myocardial ischaemia-reperfusion injury through depletion of glutathione..

GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues. (2018)
Journal Article
LIPINA, C., WALSH, S.K., MITCHELL, S.E., SPEAKMAN, J.R., WAINWRIGHT, C.L. and HUNDAL, H.S. 2019. GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues. FASEB journal [online], 33(1), pages 1299-1312. Available from: https://doi.org/10.1096/fj.201800171R

Emerging evidence indicates that G-protein coupled receptor 55 (GPR55), a nonclassic receptor of the endocannabinoid system that is activated by L-α-lysophosphatidylinositol and various cannabinoid ligands, may regulate endocrine function and energy... Read More about GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues..

Determining the role of the LPI/GPR55 system in the development of obesity and associated cardiovascular consequences. (2018)
Thesis
HAIR, S.C. 2018. Determining the role of the LPI/GPR55 system in the development of obesity and associated cardiovascular consequences. Robert Gordon University, PhD thesis.

Obesity has reached worldwide epidemic proportions and with this increased incidence of obesity, comes an increase in incidence of the comorbidities associated with obesity such as diabetes and cardiovascular disease (CVD). The underlying mechanisms... Read More about Determining the role of the LPI/GPR55 system in the development of obesity and associated cardiovascular consequences..

Studies on the role of GPR55 in cardiovascular physiology and pathophysiology. (2017)
Thesis
ROBERTSON-GRAY, O.J. 2017. Studies on the role of GPR55 in cardiovascular physiology and pathophysiology. Robert Gordon University, PhD thesis.

Atherosclerosis is a multifactorial, chronic inflammatory condition characterised by endothelial dysfunction, hyperlipidaemia and the accumulation of fatty deposits within the tunica intima of medium-to-large sized muscular arteries. This disease can... Read More about Studies on the role of GPR55 in cardiovascular physiology and pathophysiology..

The design, synthesis and evaluation of selective, non invasive imaging agents for atherosclerotic plaque. (2017)
Thesis
JESUDOSS, J.R. 2017. The design, synthesis and evaluation of selective, non invasive imaging agents for atherosclerotic plaque. Robert Gordon University, MPhil thesis.

The aim of this research study was the synthesis of an imaging agent, which could be used to non-invasively image atherosclerotic plaques via MRI. In order to achieve this, a library of peptide substrates designed to be substrate specific for either... Read More about The design, synthesis and evaluation of selective, non invasive imaging agents for atherosclerotic plaque..

New insights into the yin and yang of the endocannabinoid system in health and disease. (2016)
Journal Article
WAINWRIGHT, C. 2016. New insights into the yin and yang of the endocannabinoid system in health and disease. British journal of pharmacology [online], 173(7), pages 1113-1115. Available from: https://doi.org/10.1111/bph.13451

This article is part of a themed section on Endocannabionoids, of which the author is guest editor. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v173.7/issuetoc.

Pharmacological profiling of the hemodynamic effects of cannabinoid ligands: a combined in vitro and in vivo approach. (2015)
Journal Article
WALSH, S.K., HEPBURN, C.Y., KEOWN, O., ÅSTRAND, A., LINDBLOM, A., RYBERG, E., HJORTH, S., LESLIE, S. J., GREASLEY, P.J. and WAINWRIGHT, C.L. 2015. Pharmacological profiling of the hemodynamic effects of cannabinoid ligands: a combined in vitro and in vivo approach. Pharmacology research and perspectives [online], 3(3), e00143. Available from: https://doi.org/10.1177/1715163515578124

The receptors mediating the hemodynamic responses to cannabinoids are not clearly defined due to the multifarious pharmacology of many commonly used cannabinoid ligands. While both CB1 and TRPV1 receptors are implicated, G protein-coupled receptor 55... Read More about Pharmacological profiling of the hemodynamic effects of cannabinoid ligands: a combined in vitro and in vivo approach..

GPR55 deletion in mice leads to age-related ventricular dysfunction and impaired adrenoceptor-mediated inotropic responses. (2014)
Journal Article
WALSH, S.K., HECTOR, E.E., ANDREASSON, A.-C., JONSSON-RYLANDER, A.-C. and WAINWRIGHT, C. L. 2014. GPR55 deletion in mice leads to age-related ventricular dysfunction and impaired adrenoceptor-mediated inotropic responses. PLoS ONE [online], 9(10), article number e108999. Available from: https://doi.org/10.1371/journal.pone.0108999

G protein coupled receptor 55 (GPR55) is expressed throughout the body and, although its exact physiological function is unknown, studies have suggested that it has a role in the cardiovascular system. In particular, GPR55 has been proposed as mediat... Read More about GPR55 deletion in mice leads to age-related ventricular dysfunction and impaired adrenoceptor-mediated inotropic responses..

Studies investigating the mechanisms of the cardioprotective effects of Cannabidiol. (2014)
Thesis
HEPBURN, C.Y. 2014. Studies investigating the mechanisms of the cardioprotective effects of Cannabidiol. Robert Gordon University, PhD thesis.

The phytocannabinoid cannabidiol (CBD) has a complex pharmacology which is thought to include, but is not limited to, an ability to act as an inverse agonist at the CB1 and CB2 receptors and an antagonist of GPR55. Moreover, is has been shown to redu... Read More about Studies investigating the mechanisms of the cardioprotective effects of Cannabidiol..

Studies to determine the mechanisms of the anti-atherosclerotic effects of eicosapentaenoic acid: possible role for endocannabinoids? (2012)
Thesis
MICHEL, L. 2012. Studies to determine the mechanisms of the anti-atherosclerotic effects of eicosapentaenoic acid: possible role for endocannabinoids? Robert Gordon University, PhD thesis.

The ω-3 polyunsaturated fatty acids (ω-3 PUFAs), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have been shown to have cardioprotective and antiatherosclerotic actions. While it has been proposed that ω-3 PUFAs may structurally stabi... Read More about Studies to determine the mechanisms of the anti-atherosclerotic effects of eicosapentaenoic acid: possible role for endocannabinoids?.

Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation. (2010)
Thesis
SKENE, K.E. 2010. Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation. Robert Gordon University, PhD thesis.

Neointimal formation is a complex process that occurs due to the over compensatory healing response produced by the vessel following injury. Three key events, SMC proliferation, SMC migration and the inflammatory response, occur in unison to drive th... Read More about Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation..

Cellular mechanisms of acute hypoxic pulmonary vasoconstriction in intrapulmonary veins. (2009)
Thesis
DOSPINESCU, C. 2009. Cellular mechanisms of acute hypoxic pulmonary vasoconstriction in intrapulmonary veins. Robert Gordon University, PhD thesis.

In the pulmonary circulation, alveolar hypoxia contributes to blood flow regulation. Hypoxic pulmonary vasoconstriction (HPV) involves both pulmonary arteries and veins, but little is known of the contractile mechanisms specific to the veins. The aim... Read More about Cellular mechanisms of acute hypoxic pulmonary vasoconstriction in intrapulmonary veins..