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In vitro and in vivo antimalarial activity assays of seeds from Balanites aegyptiaca: compounds of the extract show growth inhibition and activity against Plasmodial aminopeptidase. (2011)
Journal Article
KUSCH, P., DEININGER, S., SPECHT, S., MANIAKO, R., HAUBRICH, S., POMMERENING, T., KONG THOO LIN, P., HOERAUF, A. and KAISER, A. 2011. In vitro and in vivo antimalarial activity assays of seeds from Balanites aegyptiaca: compounds of the extract show growth inhibition and activity against Plasmodial aminopeptidase. Journal of parasitology research [online], 2011, article ID 368692. Available from: https://doi.org/10.1155/2011/368692

Balanites aegyptiaca (Balanitaceae) is a widely grown desert plant with multiuse potential. In the present paper, a crude extract from B. aegyptiaca seeds equivalent to a ratio of 1:2000 seeds to the extract was screened for antiplasmodial activity.... Read More about In vitro and in vivo antimalarial activity assays of seeds from Balanites aegyptiaca: compounds of the extract show growth inhibition and activity against Plasmodial aminopeptidase..

In vitro and in vivo anticancer activity of a novel nano-sized formulation based on self-assembling polymers against pancreatic cancer. (2010)
Journal Article
HOSKINS, C., OUAISSI, M., LIMA, S.C., CHENG, W.P., LOUREIRIO, I., MAS, E., LOMBARDO, D., CORDEIRO-DA-SILVA, A., OUAISSI, A. and KONG THOO LIN, P. 2010. In vitro and in vivo anticancer activity of a novel nano-sized formulation based on self-assembling polymers against pancreatic cancer. Pharmaceutical research [online], 27(12), pages 2694-2703. Available from: https://doi.org/10.1007/s11095-010-0268-6

Purpose: To evaluate the in vitro and in vivo pancreatic anticancer activity of a nano-sized formulation based on novel polyallylamine grafted with 5% mole cholesteryl pendant groups (CH5-PAA). Methods: Insoluble novel anticancer drug, Bisnaphthalimi... Read More about In vitro and in vivo anticancer activity of a novel nano-sized formulation based on self-assembling polymers against pancreatic cancer..

Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system. (2010)
Thesis
BARRON, G. 2010. Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system. Robert Gordon University, PhD thesis.

The synthesis and characterisation of novel bisnaphthalimidopropyl polyamine (BNIPP) derivatives has gained pace over the last couple of years, as they have enhanced aqueous solubility without loss of biological activity in contrast to parent bisnaph... Read More about Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system..

The characterisation and identification of body fluid proteins for forensic purposes. (2010)
Thesis
VINCINI, L. 2010. The characterisation and identification of body fluid proteins for forensic purposes. Robert Gordon University, PhD thesis.

Advances in DNA technology have led to the extremely sensitive and rapid analysis methods used in forensic science. It can often be crucial to a criminal case to unequivocally identify the body fluid source of DNA. This is of particular importance in... Read More about The characterisation and identification of body fluid proteins for forensic purposes..

The use of novel poly(allylamine) based amphiphilic polymers for drug delivery. (2010)
Thesis
HOSKINS, C. 2010. The use of novel poly(allylamine) based amphiphilic polymers for drug delivery. Robert Gordon University, PhD thesis.

Fourteen novel comb shaped amphiphilic polymers were successfully synthesised to determine the effect of polymer architecture on the potential of these amphiphilic polymers for hydrophobic drug delivery. Polyallylamine (PAA) was grafted with four dif... Read More about The use of novel poly(allylamine) based amphiphilic polymers for drug delivery..

The effect of CLAs on the expression of PKC isoforms and cell viability in breast cancer cell lines. (2008)
Thesis
CRABB-WYKE, R. 2008. The effect of CLAs on the expression of PKC isoforms and cell viability in breast cancer cell lines. Robert Gordon University, MPhil thesis.

Breast tumours make up 15% of the total cancer burden in the UK and around 8% of the total number of cancer related deaths. Protein kinase C (PKC) isoforms have been shown to be strongly modulated in many androgen sensitive tumour cell lines. Increas... Read More about The effect of CLAs on the expression of PKC isoforms and cell viability in breast cancer cell lines..

Bioactivity of the extracts and isolation of lignans and a sesquiterpene from the aerial parts of Centaurea pamphylica (Asteraceae). (2007)
Journal Article
SHOEB, M., MACMANUS, S.M., KONG THOO LIN, P., CELIK, S., JASPARS, M., NAHR, L. and SARKER, S.D. 2007. Bioactivity of the extracts and isolation of lignans and a sesquiterpene from the aerial parts of Centaurea pamphylica (Asteraceae). DARU journal of pharmaceutical sciences [online], 15(3), pages 118-122. Available from: http://daru.tums.ac.ir/index.php/daru/article/view/315/315

Centaurea pamphylica Boiss. & Heldr. (Family: Asteraceae), commonly known as 'pamphylia daisy', is a Turkish endemic species of the genus Centaurea that comprises ca. 500 species, many of which have been used as traditional medicines. The n-hexane, d... Read More about Bioactivity of the extracts and isolation of lignans and a sesquiterpene from the aerial parts of Centaurea pamphylica (Asteraceae)..

Bioactivity of two Turkish endemic centaurea species, and their major constituents. (2007)
Journal Article
SHOEB, M., MACMANUS, S.M., JASPARS, M., KONG THOO LIN, P., NAHAR, L., CELIK, S. and SARKER, S.D. 2007. Bioactivity of two Turkish endemic centaurea species, and their major constituents. Revista Brasileira de Farmacognosia/Brazilian journal of pharmacognosy [online], 17(2), pages 155-159. Available from: https://doi.org/10.1590/S0102-695X2007000200003

The antioxidant activity, general toxicity and cytotoxicity of the methanol extracts of Centaurea urvillei subs, armata and C. mucronifera have been assessed, respectively, by the DPPH assay, the brine shrimp lethality and the MTT cytotoxicity assays... Read More about Bioactivity of two Turkish endemic centaurea species, and their major constituents..

Two oxazane macrocycles. (2004)
Journal Article
COX, P.J. and KONG THOO LIN, P. 2004. Two oxazane macrocycles. Acta crystallographica section C: structural chemistry [online], 60(5), pages o321-o324. Available from: https://doi.org/10.1107/S0108270104006687

The 20-membered ring in 1,7,11,17-tetraoxa-2,6,12,16-tetraazacycloeicosane tetrahydrochloride, C12H32N4O44+·4Cl-, adopts an endo conformation, while the 18-membered ring in 1,6,10,15-tetraoxa-2,5,11,14-tetraazacyclooctadecane tetrahydrochloride, C10H... Read More about Two oxazane macrocycles..

Morphological changes in MCF-7 human breast cancer cells in response to Bis-Naphthalimidopropylspermidine-treatment. (2002)
Journal Article
PAVLOV, V., RODILLA, V. and KONG THOO LIN, P. 2002. Morphological changes in MCF-7 human breast cancer cells in response to Bis-Naphthalimidopropylspermidine-treatment. Biotechnology and biotechnological equipment [online], 16(1), pages 118-123. Available from: https://doi.org/10.1080/13102818.2002.10819165

The effects of bis-naphthalimidopropylspermidine (BNIPSpd), a representative of a novel class of polyamine derivatives with antiproliferative properties on the morphology of MCF-7 human breast cancer cells were studied. BNIPSpd was shown to cause cyt... Read More about Morphological changes in MCF-7 human breast cancer cells in response to Bis-Naphthalimidopropylspermidine-treatment..

Rerefinement of (μ-1,7,11,17-tetraoxa-2,6,12,16-tetraazacycloeicosane-κ4N1,N17:N7,N11)bis[dichlorozinc(II)]. [Dataset] (2002)
Dataset
KUKSA, V.A., WARDELL, S.M.S.V. , KONG THOO LIN, P. and HOWIE, R.A. 2002. Rerefinement of ([mu]-1,7,11,17-tetraoxa-2,6,12,16-tetra­aza­cyclo­ei­cosane-[kappa]4N1,N17:N7,N11)­bis­[di­chlorozinc(II)]. [Dataset]. Acta crystallographica section E: crystallographic communications [online], 58(2), pages m68-m69. Available from: https://doi.org/10.1107/S1600536802001654

This rerefinement of the title compound, [Zn2Cl4(C12H28­N4O4)], based on the original intensity data, differs from the original only in the exchange of the NH and O moieties of the oxa­aza-macrocycle, resulting in a dramatic improvement in the R fact... Read More about Rerefinement of (μ-1,7,11,17-tetraoxa-2,6,12,16-tetraazacycloeicosane-κ4N1,N17:N7,N11)bis[dichlorozinc(II)]. [Dataset].

6-(3,5-Di-O-acetyl-β-D-2-deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7(6H)-one. [Dataset] (1995)
Dataset
VAN MEERVELT, L., KONG THOO LIN, P. and BROWN, D.M. 1995. 6-(3,5-Di-O-acetyl-β-D-2-deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7(6H)-one. [Dataset] Acta crystallographica section C: crystal structure communications [online], 51(7), pages 1347-1350. Available from: https://doi.org/10.1107/s0108270195000096

The title compound, C15H19N3O7 (P), crystallizes with two molecules in the asymmetric unit which differ in sugar and oxazino ring puckering; both occur as the imino tautomer and form P;P wobble base pairs. The supporting information for the published... Read More about 6-(3,5-Di-O-acetyl-β-D-2-deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7(6H)-one. [Dataset].

Direct observation of two base-pairing modes of a cytosine-thymine analogue with guanine in a DNA z-form duplex: significance for base analogue mutagenesis. [Dataset] (1995)
Dataset
MOORE, M.H., VAN MEERVELT, L., SALISBURY, S.A., KONG THOO LIN, P. and BROWN, D.M. 1995. Direct observation of two base-pairing modes of a cytosine-thymine analogue with guanine in a DNA z-form duplex: significance for base analogue mutagenesis. [Dataset]. Hosted on Worldwide Protein Data Bank (wwPDB) [online], 223D. Available from: https://doi.org/10.2210/pdb223d/pdb

The pyrimidine nucleobase analogue 6H,8H-3,4-dihydropyrimido[4,5-c]-[1,2]oxazin-7-one (P) is a mimic both of cytosine and thymine, since it can form stable hydrogen-bonded base-pairs with either guanine or adenine. To investigate the geometric proper... Read More about Direct observation of two base-pairing modes of a cytosine-thymine analogue with guanine in a DNA z-form duplex: significance for base analogue mutagenesis. [Dataset].

Synthesis of oligodeoxyribonucleotides containing degenerate bases and their use as primers in the polymerase chain reaction. (1992)
Journal Article
KONG THOO LIN, P. and BROWN, D.M. 1992. Synthesis of oligodeoxyribonucleotides containing degenerate bases and their use as primers in the polymerase chain reaction. Nucleic acids research [online], 20(19), pages 5149-5152. Available from: https://doi.org/10.1093/nar/20.19.5149

Heptadecaoligodeoxyribonudeotides containing one or more of the bases, 6H,8H-3,4-dihydropyrimido[4,5-c] [1,2]oxazin-7-one (P), 2-amino-6-methoxyaminopurine (K), and hypoxanthine (I) and combinations of P with K and I have been synthesised on a DNA sy... Read More about Synthesis of oligodeoxyribonucleotides containing degenerate bases and their use as primers in the polymerase chain reaction..

Synthesis and duplex stability of oligonucleotides containing cytosine-thymine analogues. (1989)
Journal Article
KONG THOO LIN, P. and BROWN, D.M. 1989. Synthesis and duplex stability of oligonucleotides containing cytosine-thymine analogues. Nucleic acids research [online], 17(24), pages 10373-10383. Available from: https://doi.org/10.1093/nar/17.24.10373

The synthesis of the deoxynucleoside derived from the base P, 6H, 8H-3, 4-dihydro-pyrimido[4, 5-c][1, 2] oxazin-7-one, 2, and its introduction by established phosphoramidite and H-phosphonate chemistry into oligonucleotides is described. The melting... Read More about Synthesis and duplex stability of oligonucleotides containing cytosine-thymine analogues..