Synthesis and duplex stability of oligonucleotides containing cytosine-thymine analogues.

Kong Thoo Lin, P.; Brown, Daniel M.

doi:10.1093/nar/17.24.10373

Occurrence of toxigenic cyanobacterial blooms in freshwaters of Sri Lanka. (2005)
Journal Article
JAYATISSA, L.P., SILVA, E.I.L., MCELHINEY, J. and LAWTON, L.A. 2006. Occurrence of toxigenic cyanobacterial blooms in freshwaters in Sri Lanka. Systematic and applied microbiology [online], 29(2), pages 156-164. Available from: https://doi.org/10.1016/j.syapm.2005.07.007

A previous pioneering study of freshwater bodies in Sri Lanka revealed the presence of toxic cyanobacteria in three out of four water bodies tested. It was therefore important to perform a more detailed investigation into the presence of cyanobacteri... Read More about Occurrence of toxigenic cyanobacterial blooms in freshwaters of Sri Lanka..

Cytochrome P450 CYP1B1 activity in renal cell carcinoma. (2004)
Journal Article
MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 2004. Cytochrome P450 CYP1B1 activity in renal cell carcinoma. British journal of cancer [online], 91, pages 966-971. Available from: https://doi.org/10.1038/sj.bjc.6602053

Renal cell carcinoma (RCC) is the most common malignancy of the kidney and has a poor prognosis due to its late presentation and resistance to current anticancer drugs. One mechanism of drug resistance, which is potentially amenable to therapeutic in... Read More about Cytochrome P450 CYP1B1 activity in renal cell carcinoma..

Two oxazane macrocycles. (2004)
Journal Article
COX, P.J. and KONG THOO LIN, P. 2004. Two oxazane macrocycles. Acta crystallographica section C: structural chemistry [online], 60(5), pages o321-o324. Available from: https://doi.org/10.1107/S0108270104006687

The 20-membered ring in 1,7,11,17-tetraoxa-2,6,12,16-tetraazacycloeicosane tetrahydrochloride, C12H32N4O44+·4Cl-, adopts an endo conformation, while the 18-membered ring in 1,6,10,15-tetraoxa-2,5,11,14-tetraazacyclooctadecane tetrahydrochloride, C10H... Read More about Two oxazane macrocycles..

On-line monitoring of laser modification of titanium dioxide using optical surface second harmonic. (2004)
Journal Article
VRILLET, G., LEE, S.K., McSTAY, D. and ROBERTSON, P.K.J. 2004. On-line monitoring of laser modification of titanium dioxide using optical surface second harmonic. Applied surface science [online], 222(1-4), pages 33-42. Available from: https://doi.org/10.1016/j.apsusc.2003.07.003

TiO2 photocatalysis is a promising technology for the destruction of organic pollutants in both waste and potable waters with the mineralisation of a wide range of compounds having been reported. TiO2 has many advantages over other semiconductors, it... Read More about On-line monitoring of laser modification of titanium dioxide using optical surface second harmonic..

The destruction of 2-methylisoborneol and geosmin using titanium dioxide photocatalysis. (2003)
Journal Article
LAWTON, L.A., ROBERTSON, P.K.J., ROBERTSON, R.F. and BRUCE, F.G. 2003. The destruction of 2-methylisoborneol and geosmin using titanium dioxide photocatalysis. Applied catalysis B: environmental [online], 44(1), pages 9-13. Available from: https://doi.org/10.1016/S0926-3373(03)00005-5

Geosmin (GSM) and 2-methylisoborneol (MIB) are semi-volatile compounds produced by cyanobacteria in surface waters. These compounds present problems to the drinking water industry and in aquaculture because they can taint water and fish producing an... Read More about The destruction of 2-methylisoborneol and geosmin using titanium dioxide photocatalysis..

Processes influencing surface interaction and photocatalytic destruction of microcystins on titanium dioxide photocatalysts. (2002)
Journal Article
LAWTON, L., ROBERTSON, P., CORNISH, B., MARR, I. and JASPARS, M. 2003. Processes influencing surface interaction and photocatalytic destruction of microcystins on titanium dioxide photocatalysts. Journal of catalysis [online], 213(1), pages 109-113. Available from: https://doi.org/10.1016/S0021-9517(02)00049-0

Microcystins are a family of hepatotoxic peptides produced by freshwater cyanobacteria. Their occurrence in drinking water is of concern since chronic exposure to these toxins causes tumor promotion. It is therefore essential to establish a reliable... Read More about Processes influencing surface interaction and photocatalytic destruction of microcystins on titanium dioxide photocatalysts..

Morphological changes in MCF-7 human breast cancer cells in response to Bis-Naphthalimidopropylspermidine-treatment. (2002)
Journal Article
PAVLOV, V., RODILLA, V. and KONG THOO LIN, P. 2002. Morphological changes in MCF-7 human breast cancer cells in response to Bis-Naphthalimidopropylspermidine-treatment. Biotechnology and biotechnological equipment [online], 16(1), pages 118-123. Available from: https://doi.org/10.1080/13102818.2002.10819165

The effects of bis-naphthalimidopropylspermidine (BNIPSpd), a representative of a novel class of polyamine derivatives with antiproliferative properties on the morphology of MCF-7 human breast cancer cells were studied. BNIPSpd was shown to cause cyt... Read More about Morphological changes in MCF-7 human breast cancer cells in response to Bis-Naphthalimidopropylspermidine-treatment..

Mechanistic and toxicity studies of the photocatalytic oxidation of microcystin-LR. (2002)
Journal Article
LIU, I., LAWTON, L.A., CORNISH, B. and ROBERTSON, P., 2002. Mechanistic and toxicity studies of the photocatalytic oxidation of microcystin-LR. Journal of photochemistry and photobiology A: chemistry [online], 148(1-3), pages 349-354. Available from: https://doi.org/10.1016/S1010-6030(02)00062-X

Cyanobacterial toxins present in drinking water sources pose a considerable threat to human health. Conventional water treatment systems have proven unreliable for the removal of these toxins and hence new techniques have been investigated. Previous... Read More about Mechanistic and toxicity studies of the photocatalytic oxidation of microcystin-LR..

Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer. (2001)
Journal Article
MCFADYEN, M.C.E., CRUICKSHANK, M.E., MILLER, I.D., MCLEOD, H.L., MELVIN, W.T., HAITES, N.E., PARKIN, D. and MURRAY, G.I. 2001. Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer. British journal of cancer [online], 85(2), pages 242-246. Available from: https://doi.org/10.1054/bjoc.2001.1907

Ovarian cancer is the most frequent cause of death from gynaecological malignancies world wide. Little improvement has been made in the long-term outcome of this disease, with the 5-year survival of patients only 30%. This poor prognosis is due to th... Read More about Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer..

Physico-chemical treatment methods for the removal of microcystins (cyanobacterial hepatotoxins) from potable waters. (1999)
Journal Article
LAWTON, L.A. and ROBERTSON, P.K.J. 1999. Physico-chemical treatment methods for the removal of microcystins (cyanobacterial hepatotoxins) from potable waters. Chemical society reviews [online], 28(4), pages 217-224. Available from: https://doi.org/10.1039/A805416I

The incidence of cyanobacterial blooms in freshwaters, including drinking water reservoirs, has increased over the past few decades due to rising nutrient levels. Microcystins are hepatotoxins released from cyanobacteria and have been responsible for... Read More about Physico-chemical treatment methods for the removal of microcystins (cyanobacterial hepatotoxins) from potable waters..

Cytochrome P450 CYP3A in human renal cell cancer. (1999)
Journal Article
MURRAY, G.I., MCFADYEN, M.C.E., MITCHELL, R.T., CHEUNG, Y.-L., KERR, A.C. and MELVIN, W.T. 1999. Cytochrome P450 CYP3A in human renal cell cancer. British journal of cancer [online], 79(11-12), pages 1836-1842. Available from: https://doi.org/10.1038/sj.bjc.6690292

Renal cell cancer is the main malignant tumour of the kidney and has an increasing incidence. This type of tumour has a poor prognosis and shows intrinsic resistance to several anti-cancer drugs. The CYP3A P450 family, which consists of three closely... Read More about Cytochrome P450 CYP3A in human renal cell cancer..

Processes influencing the destruction of microcystin-LR by TiO2 photocatalysis. (1998)
Journal Article
ROBERTSON, P.K.J., LAWTON, L.A., CORNISH, B.J.P.A. and JASPARS, M. 1998. Processes influencing the destruction of Microcystin-LR by TiO2 photocatalysis. Journal of photochemistry and photobiology A: chemistry [online], 116(3), pages 215-219. Available from: https://doi.org/10.1016/S1010-6030(98)00312-8

We have previously reported the effectiveness of TiO2 photocatalysis in the destruction of the cyanotoxin microcystin-LR [P.K.J. Robertson, L.A. Lawton, B. Münch, J. Rouzade, J. Chem. Soc., Chem. Commun., 4 (1997) 393; P.K.J. Robertson, L.A. Lawton,... Read More about Processes influencing the destruction of microcystin-LR by TiO2 photocatalysis..

Destruction of cyanobacterial toxins by semiconductor photocatalysis. (1997)
Journal Article
ROBERTSON, P.K.J., LAWTON, L.A., MÜNCH, B. and ROUZADE, J. 1997. Destruction of cyanobacterial toxins by semiconductor photocatalysis. Chemical communications [online], 4, pages 393-394. Available from: https://doi.org/10.1039/A607965B

The rapid destruction of microcystin, a cyanobacterial toxin, using a titanium dioxide photocatalyst is observed; the process is extremely efficient with high concentrations of toxin completely undetectable within 10-40 min, depending on the initial... Read More about Destruction of cyanobacterial toxins by semiconductor photocatalysis..

Synthesis of oligodeoxyribonucleotides containing degenerate bases and their use as primers in the polymerase chain reaction. (1992)
Journal Article
KONG THOO LIN, P. and BROWN, D.M. 1992. Synthesis of oligodeoxyribonucleotides containing degenerate bases and their use as primers in the polymerase chain reaction. Nucleic acids research [online], 20(19), pages 5149-5152. Available from: https://doi.org/10.1093/nar/20.19.5149

Heptadecaoligodeoxyribonudeotides containing one or more of the bases, 6H,8H-3,4-dihydropyrimido[4,5-c] [1,2]oxazin-7-one (P), 2-amino-6-methoxyaminopurine (K), and hypoxanthine (I) and combinations of P with K and I have been synthesised on a DNA sy... Read More about Synthesis of oligodeoxyribonucleotides containing degenerate bases and their use as primers in the polymerase chain reaction..

Polyamide profiles of porcine milk and of intestinal tissue of pigs during suckling. (1991)
Journal Article
KELLY, D., KING, T.P., BROWN, D.S. and MCFADYEN, M. 1991. Polyamide profiles of porcine milk and of intestinal tissue of pigs during suckling. Reproduction nutrition development [online], 31(1), pages 73-80. Available from: https://doi.org/10.1051/rnd:19910107

Previous studies have suggested that luminal polyamines can directly influence intestinal differentiation of neonatal rats. The present investigation has demonstrated the presence of high levels of polyamines in porcine milk and in the intestinal tis... Read More about Polyamide profiles of porcine milk and of intestinal tissue of pigs during suckling..

Pattern of gastric emptying in the pig: relation to feeding. (1990)
Journal Article
GREGORY, P.C., MCFADYEN, M. and RAYNER, D.V. 1990. Pattern of gastric emptying in the pig: relation to feeding. British journal of nutrition [online], 64(1), pages 45-58. Available from: https://doi.org/10.1079/bjn19900008

The aims of the present study were to compare the gastric emptying of dry matter (DM) and liquids during the feeding period with that following meal consumption, to clarify the relationship between feeding and gastric emptying, and to investigate how... Read More about Pattern of gastric emptying in the pig: relation to feeding..

Synthesis and duplex stability of oligonucleotides containing cytosine-thymine analogues. (1989)
Journal Article
KONG THOO LIN, P. and BROWN, D.M. 1989. Synthesis and duplex stability of oligonucleotides containing cytosine-thymine analogues. Nucleic acids research [online], 17(24), pages 10373-10383. Available from: https://doi.org/10.1093/nar/17.24.10373

The synthesis of the deoxynucleoside derived from the base P, 6H, 8H-3, 4-dihydro-pyrimido[4, 5-c][1, 2] oxazin-7-one, 2, and its introduction by established phosphoramidite and H-phosphonate chemistry into oligonucleotides is described. The melting... Read More about Synthesis and duplex stability of oligonucleotides containing cytosine-thymine analogues..

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