All Outputs (62)

Synthesis and evaluation of polymer-drug conjugates as potential antioxidant and cholinesterase inhibitors for neurodegenerative diseases. (2024)
Journal Article
MAHADIK, N., BARRON, G., KONG THOO LIN, P. and THOMPSON, C. 2024. Synthesis and evaluation of polymer-drug conjugates as potential antioxidant and cholinesterase inhibitors for neurodegenerative diseases. Chemistry of materials [online], 36(21), pages 10514-10527. Available from: https://doi.org/10.1021/acs.chemmater.4c01767

Polymer-drug conjugates (PDCs) may offer improved water-solubility and in vitro activity of potential antioxidant and cholinesterase (ChE) inhibitor drugs compared to the drugs alone. Conjugation of these potential drugs to water-soluble polymers cou... Read More about Synthesis and evaluation of polymer-drug conjugates as potential antioxidant and cholinesterase inhibitors for neurodegenerative diseases..

Polymer-drug conjugates as nano-sized multi-targeting systems for the treatment of Alzheimer's disease. (2024)
Journal Article
MAHADIK, N., BARRON, G.A., KONG THOO LIN, P. and THOMPSON, C.J. 2024. Polymer-drug conjugates as nano-sized multi-targeting systems for the treatment of Alzheimer's disease. RSC pharmaceutics [online], 1(2), pages 161-181. Available from: https://doi.org/10.1039/D3PM00075C

Alzheimer's disease (AD) is a progressive, neurodegenerative condition. There are clear markers for the presence and progression of the disease, including β-amyloid (Aβ) plaques and Tau tangles, with many potential causes debated in the scientific co... Read More about Polymer-drug conjugates as nano-sized multi-targeting systems for the treatment of Alzheimer's disease..

Pharmacological inhibition of acetylcholinesterase improves the locomotion defective phenotype of a SCA3 C. elegans model. (2024)
Journal Article
POHL, F., LINDSAY-MCGEE, V., KONG THOO LIN, P., MACIEL, P. and TEIXEIRA-CASTRO, A. 2024. Pharmacological inhibition of acetylcholinesterase improves the locomotion defective phenotype of a SCA3 C. elegans model. microPublication biology [online], 2024(2), 001086. Available from: https://doi.org/10.17912/micropub.biology.001086

Inhibition of acetylcholinesterase (AChE) is a common used treatment option for Alzheimer's disease. However, there has been limited research on the potential use of AChE inhibitors for the treatment of Machado-Joseph disease (MJD)/Spinocerebellar At... Read More about Pharmacological inhibition of acetylcholinesterase improves the locomotion defective phenotype of a SCA3 C. elegans model..

UNC-49 is a redox-sensitive GABAA receptor that regulates the mitochondrial unfolded protein response cell nonautonomously. (2023)
Journal Article
POHL, F., GERMANN, A.L., MAO, J., HOU, S., BAKARE, B., KONG THOO LIN, P., YATES, K., NONET, M.L., AKK, G., KORNFELD, K. and HELD, J.M. 2023. UNC-49 is a redox-sensitive GABAA receptor that regulates the mitochondrial unfolded protein response cell nonautonomously. Science advances [online], 9(44). Available from: https://doi.org/10.1126/sciadv.adh2584

The γ-aminobutyric acid–mediated (GABAergic) system participates in many aspects of organismal physiology and disease, including proteostasis, neuronal dysfunction and life-span extension. Many of these phenotypes are also regulated by reactive oxyge... Read More about UNC-49 is a redox-sensitive GABAA receptor that regulates the mitochondrial unfolded protein response cell nonautonomously..

Valorisation of whisky distillery waste as a sustainable source of antioxidant and antibacterial properties with neuroprotective potential. (2023)
Journal Article
BLAIKIE, L., WELGAMAGE DON, A., FRANZEN, X., FERNANDEZ, C., FAISAL, N. and KONG THOO LIN, P. 2024. Valorisation of whisky distillery waste as a sustainable source of antioxidant and antibacterial properties with neuroprotective potential. Waste and biomass valorization [online], 15(4), pages 2333-2343. Available from: https://doi.org/10.1007/s12649-023-02292-4

Waste by-products such as pot ale are abundantly produced during the whisky distillation process and are conventionally used as livestock feed, however a significant proportion continues to require land and sea disposal. Here, the novel potential of... Read More about Valorisation of whisky distillery waste as a sustainable source of antioxidant and antibacterial properties with neuroprotective potential..

Experimental modelling of Alzheimer’s disease for therapeutic screening. (2022)
Journal Article
BLAIKIE, L., KAY, G., MACIEL, P. and KONG THOO LIN, P. 2022. Experimental modelling of Alzheimer’s disease for therapeutic screening. European journal of medicinal chemistry reports [online], 5, article 100044. Available from: https://doi.org/10.1016/j.ejmcr.2022.100044

Neurodegenerative diseases, including Alzheimer’s disease (AD), pose a significant and urgent challenge to healthcare systems worldwide. With an increasing life expectancy, these progressive age-related disorders are expected to rise exponentially. N... Read More about Experimental modelling of Alzheimer’s disease for therapeutic screening..

DNA profiling of single sperm cells after whole genome amplification. (2021)
Journal Article
THEUNISSEN, G.M.G., GIBB, A., KONG THOO LIN, P., ROLF, B., FORAT, S. and JÄGER, R. 2021. DNA profiling of single sperm cells after whole genome amplification. Forensic science international: reports [online], 4, article 100240. Available from: https://doi.org/10.1016/j.fsir.2021.100240

Intimate swabs taken for examination in sexual assault cases typically yield mixtures of sperm and epithelial cell types. While powerful, differential extraction protocols to overcome such cell type mixtures by separate lysis of epithelial cells and... Read More about DNA profiling of single sperm cells after whole genome amplification..

Novel nanoparticle drug delivery systems: application in the in vitro study of Bisnaphthalimidopropyl derivatives against human colorectal cancer cell lines. (2021)
Thesis
BRUNET, M. 2021. Novel nanoparticle drug delivery systems: application in the in vitro study of Bisnaphthalimidopropyl derivatives against human colorectal cancer cell lines. Robert Gordon University, MRes thesis. Hosted on OpenAIR [online]. Available from: https://doi.org/10.48526/rgu-wt-1446968

Colorectal cancer is one of the most severe causes of mortality worldwide accounting for 10% of total cancer cases. Although recent advances in early diagnosis have reduced the mortality rate associated with CRC, patients suffering from the later met... Read More about Novel nanoparticle drug delivery systems: application in the in vitro study of Bisnaphthalimidopropyl derivatives against human colorectal cancer cell lines..

Impact of rapeseed pomace extract on markers of oxidative stress and DNA damage in human SH‐SY5Y cells. (2020)
Journal Article
POHL, F., GOUA, M., YATES, K., BERMANO, G., RUSSELL, W.R., MACIEL, P. and KONG THOO LIN, P. 2021. Impact of rapeseed pomace extract on markers of oxidative stress and DNA damage in human SH‐SY5Y cells. Journal of food biochemistry [online], 45(2), article e13592. Available from: https://doi.org/10.1111/jfbc.13592

With increased longevity and subsequent rise in people with age-related neurodegenerative diseases, protection of neurons from oxidative stress damage has become an important field of study. For the first time, we highlight the neuroprotective proper... Read More about Impact of rapeseed pomace extract on markers of oxidative stress and DNA damage in human SH‐SY5Y cells..

Electroanalytical determination of gallic acid in red and white wine samples using cobalt oxide nanoparticles-modified carbon-paste electrodes. (2020)
Journal Article
CHIKERE, C.O., HOBBEN, E., FAISAL, N.H., KONG THOO LIN, P. and FERNANDEZ, C. 2021. Electroanalytical determination of gallic acid in red and white wine samples using cobalt oxide nanoparticles-modified carbon-paste electrodes. Microchemical journal [online], 160(part B), article ID 105668. Available from: https://doi.org/10.1016/j.microc.2020.105668

Beverages like wines, have exhibited a high level of antioxidant capacity, specifically from compounds like Gallic acid (GA) and their derivatives. GA has shown great importance in the food industry and pharmaceutical industry as a food additive, ant... Read More about Electroanalytical determination of gallic acid in red and white wine samples using cobalt oxide nanoparticles-modified carbon-paste electrodes..

Synthesis and in vitro evaluation of vanillin derivatives as multi-target therapeutics for the treatment of Alzheimer’s disease. (2020)
Journal Article
BLAIKIE, L., KAY, G. and KONG THOO LIN, P. 2020. Synthesis and in vitro evaluation of vanillin derivatives as multi-target therapeutics for the treatment of Alzheimer's disease. Bioorganic and medical chemistry letters [online], 30(21), article ID 127505. Available from: https://doi.org/10.1016/j.bmcl.2020.127505

A number of novel naphthalimido and phthalimido vanillin derivatives were synthesised, and evaluated as antioxidants and cholinesterase inhibitors in vitro. Antioxidant activity was assessed using DPPH, FRAP, and ORAC assays. All compounds demonstrat... Read More about Synthesis and in vitro evaluation of vanillin derivatives as multi-target therapeutics for the treatment of Alzheimer’s disease..

Electrochemical determination of gallic acid in food matrices using novel materials. (2020)
Thesis
CHIKERE, C.O. 2020. Electrochemical determination of gallic acid in food matrices using novel materials. Robert Gordon University [online], PhD thesis. Available from: https://openair.rgu.ac.uk

Gallic acid (GA), as an endogenous polyphenol, has shown many different important properties that have influenced its use in the food and pharmaceutical industry. These properties include its antioxidant, anti-cancer, anti-tumor, anti-HIV and anti-ul... Read More about Electrochemical determination of gallic acid in food matrices using novel materials..

DNA profiling of single sperm cells and single skin flakes in forensics using micromanipulation and whole genome amplification. (2020)
Thesis
THEUNISSEN, G.M.G. 2020. DNA profiling of single sperm cells and single skin flakes in forensics using micromanipulation and whole genome amplification. Robert Gordon University [online], PhD thesis. Available from: https://openair.rgu.ac.uk

In forensic DNA profiling, the occurrence of complex mixed profiles is currently a common issue. Cases involving intimate swabs or skin flake tape liftings are prone to mixed profiles, because of more than one donor contributing to a DNA sample. By D... Read More about DNA profiling of single sperm cells and single skin flakes in forensics using micromanipulation and whole genome amplification..

Interaction between amorphous zirconia nanoparticles and graphite: electrochemical applications for gallic acid sensing using carbon paste electrodes in wine. (2020)
Journal Article
CHIKERE, C.O., FAISAL, N.H., KONG THOO LIN, P. and FERNANDEZ, C. 2020. Interaction between amorphous zirconia nanoparticles and graphite: electrochemical applications for gallic acid sensing using carbon paste electrodes in wine. Nanomaterials [online], 10(3), article ID 537. Available from: https://doi.org/10.3390/nano10030537

Amorphous zirconium oxide nanoparticles (ZrO2) have been used for the first time, to modify carbon paste electrode (CPE) and used as a sensor for the electrochemical determination of gallic acid (GA). The voltammetric results of the ZrO2 nanoparticle... Read More about Interaction between amorphous zirconia nanoparticles and graphite: electrochemical applications for gallic acid sensing using carbon paste electrodes in wine..

GST-4-dependent suppression of neurodegeneration in C. elegans models of Parkinson’s and Machado-Joseph Disease by rapeseed pomace extract supplementation. (2019)
Journal Article
POHL, F., TEIXEIRA-CASTRO, A., COSTA, M.D., LINDSAY, V., FIÚZA-FERNANDES, J., GOUA, M., BERMANO, G., RUSSELL, W., MACIEL, P. and KONG THOO LIN, P. 2019. GST-4-dependent suppression of neurodegeneration in C. elegans models of Parkinson’s and Machado-Joseph Disease by rapeseed pomace extract supplementation. Frontiers in neuroscience [online], 13, article ID 1091. Available from: https://doi.org/10.3389/fnins.2019.01091

Genetic mutations and aging-associated oxidative damage underlie the onset and progression of neurodegenerative diseases, like Parkinson’s disease (PD) and Machado-Joseph disease (MJD). Natural products derived from plants have been regarded as impor... Read More about GST-4-dependent suppression of neurodegeneration in C. elegans models of Parkinson’s and Machado-Joseph Disease by rapeseed pomace extract supplementation..

Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands. (2019)
Journal Article
BLAIKIE, L., KAY, G. and KONG THOO LIN, P. 2019. Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands. MedChemComm [online], 10(12), pages 2052-2072. Available from: https://doi.org/10.1039/c9md00337a

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, and a major cause of death worldwide. The number of people suffering from this debilitating disorder is rising at an unprecedented rate, with a subsequent surge in healthcare c... Read More about Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands..

Synthesis of novel vanillin derivatives: study of their antioxidant and potential neuroprotective properties. (2019)
Thesis
SCIPIONI, M. 2019. Synthesis of novel vanillin derivatives: study of their antioxidant and potential neuroprotective properties. Robert Gordon University [online], PhD thesis. Available from: https://openair.rgu.ac.uk

Vanillin (4-hydroxy-3-methoxybenzaldehyde) is a naturally-occurring phenolic compound, forming the main component of the bean and pod of vanilla orchids. It is widely used as a flavouring agent in food and drinks, and as a preservative in the cosmeti... Read More about Synthesis of novel vanillin derivatives: study of their antioxidant and potential neuroprotective properties..

The synergistic effect between graphene oxide nanocolloids and silicon dioxide nanoparticles for gallic acid sensing. (2019)
Journal Article
CHIKERE, C.O., FAISAL, N.H., KONG THOO LIN, P. and FERNANDEZ, C. 2019. The synergistic effect between graphene oxide nanocolloids and silicon dioxide nanoparticles for gallic acid sensing. Journal of solid state electrochemistry [online], 23(6), pages 1795-1809. Available from: https://doi.org/10.1007/s10008-019-04267-9

For the first time, the synergistic effect of graphene oxide nanocolloids (nano-GO) and silicon dioxide (silica) nanoparticles (SiO2-nanoparicles) has been used to modify a glassy carbon electrode (GCE) for the determination of gallic acid (GA). The... Read More about The synergistic effect between graphene oxide nanocolloids and silicon dioxide nanoparticles for gallic acid sensing..

Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer's disease. (2019)
Journal Article
SCIPIONI, M., KAY, G., MEGSON, I.L. and KONG THOO LIN, P. 2019. Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer’s disease. MedChemComm [online], 10(5), pages 764-777. Available from: https://doi.org/10.1039/c9md00048h

Alzheimer’s Disease (AD) is the most common cause of dementia worldwide, normally affecting people aged over 65. Due to the multifactorial nature of this disease, a “multi-target-directed ligands” (MTDLs) approach for the treatment of this illness ha... Read More about Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer's disease..

The potential application of rapeseed pomace extracts in the prevention and treatment of neurodegenerative diseases. (2019)
Thesis
POHL, F. 2019. The potential application of rapeseed pomace extracts in the prevention and treatment of neurodegenerative diseases. Robert Gordon University [online], PhD thesis. Available from: https://openair.rgu.ac.uk

Rapeseed pomace (RSP) is the waste/by-product obtained after edible oil production from Brassica napus and is currently used as animal feed. In an attempt to revalorize this by-product as a potential nutraceutical for the treatment or prevention of n... Read More about The potential application of rapeseed pomace extracts in the prevention and treatment of neurodegenerative diseases..