Dr Sarah Walsh's Projects (11)

Bioactivity of a compound derived from Amaryllidaceae (Daffodil) in a C.elegans model of obesity Sep 1, 2023 - May 30, 2024
A previous proof-of-concept study demonstrated that an alkaloid extracted from daffodil bulbs by Agroceutical Products Ltd (APL), alongside sustainable galanthamine production (alkaloid used for Alzheimer’s disease management), selectively reduced re... Read More about Bioactivity of a compound derived from Amaryllidaceae (Daffodil) in a C.elegans model of obesity.

Exploring the anti-atherogenic properties of a compound derived from Amaryllidaceae (Daffodil) Sep 1, 2023 - Apr 30, 2024
Agroceutical Products Ltd (APL) produces sustainable quantities of the naturally derived alkaloid galanthamine from daffodils, which is a key active pharmaceutical used for the treatment of Alzheimer’s disease. Daffodils contain an abundance of other... Read More about Exploring the anti-atherogenic properties of a compound derived from Amaryllidaceae (Daffodil).

The role of Glutathione Peroxidase 4 (GPX4) and the GPX4 single-nucleotide polymorphism (SNP), rs713041, in metabolic syndrome associated vascular dysfunction Sep 1, 2023 - Apr 30, 2025
High blood sugar, high blood pressure, and obesity are all features of the ‘umbrella term’ metabolic syndrome (MetS) which affects 1 in 3 people over 50 years old in the UK. MetS increases the risk of developing heart disease and in particular the co... Read More about The role of Glutathione Peroxidase 4 (GPX4) and the GPX4 single-nucleotide polymorphism (SNP), rs713041, in metabolic syndrome associated vascular dysfunction.

Cannabidiol and CBD oil for prevention of cardiac dysfunction Mar 9, 2023 - Dec 19, 2024
Cannabidiol (CBD) has cardioprotective properties against the outcome of myocardial ischaemia and reperfusion. CBD oil, which contains not only cannabidiol but a host of biologically active molecules that may also offer some benefits to cardiac heal... Read More about Cannabidiol and CBD oil for prevention of cardiac dysfunction.

Valorisation of Biomass from the Daffodil Growing Industry Oct 1, 2021 - Sep 30, 2025
The UK is a world leader in the commercial production of daffodils, with Scottish-based farmers’ cooperative Grampian Growers Ltd (GG) at the forefront of the industry. The majority of daffodil biomass produced by GG is used for bulb and flower expo... Read More about Valorisation of Biomass from the Daffodil Growing Industry.

Bioactivity of compounds derived from Amaryllicaea (Daffodil) Feb 1, 2021 - Jul 31, 2022
Heart Failure (HF) is a long-term complication of cardiovascular (high blood pressure and heart attack) and cardiovascular-related (obesity and metabolic syndrome) disorders and of drug-induced cardiotoxicity. HF is characterised by thickening (hype... Read More about Bioactivity of compounds derived from Amaryllicaea (Daffodil).

A novel G protein-coupled receptor target for metabolic syndrome Sep 1, 2020 - Feb 28, 2022
Metabolic syndrome is the medical term for a group of risk factors that increase the likelihood of developing heart disease, diabetes, and stroke. The risk factors for metabolic syndrome include high blood pressure, high blood sugar (insulin resistan... Read More about A novel G protein-coupled receptor target for metabolic syndrome.

Protective effects of cannabidiol in doxorubicin induced cardiotoxicity Oct 1, 2018 - Dec 31, 2019

Exploring the relationship between age-related zinc deficiency and obesity and the extent of myocardial damage following acute myocardial infarction Oct 1, 2018 - Jan 1, 2021
Zinc (Zn 2+) is a metal found in trace amounts in the body and plays an essential role in maintaining the healthy functioning of most organs, including the heart. The body does not store zinc in large quantities and so replenishment of Zn 2+ through... Read More about Exploring the relationship between age-related zinc deficiency and obesity and the extent of myocardial damage following acute myocardial infarction.

sFRPs as a novel modulator of diastolic heart failure Oct 1, 2017 - Dec 31, 2021
Following a heart attack, or because of persistently high blood pressure the heart is damaged and has to work harder to circulate blood around the body. This condition is known as heart failure. In the UK alone, 500,000 people have heart failure re... Read More about sFRPs as a novel modulator of diastolic heart failure.

Protective effects of cannabidiol in combined chemotherapy induced cardiotoxicity Jul 8, 2019 - Sep 1, 2019
Doxorubicin, an anthracycline, is one of the most effective and commonly used drugs for the treatment of cancer. This anthracycline is used both alone and in combination with other chemotherapeutic agents such as taxanes e.g. paclitaxel. Despite its... Read More about Protective effects of cannabidiol in combined chemotherapy induced cardiotoxicity.