A Scottish and Japanese experience of patient-centred diabetic care: descriptive study of interprofessional education on live webinar. (2018)
Journal Article
SUEMATSU, M., JOSEPH, S., ABE, K., YASUI, H., TAKAHASHI, N., OKAZAKI, K., HAXTON, J., MCFADYEN, M., WALKER, P. and DIACK, L. 2018. A Scottish and Japanese experience of patient-centred diabetic care: descriptive study of interprofessional education on live webinar. Nagoya journal of medical science [online], 80(4), pages 465-473. Available from: https://doi.org/10.18999/nagjms.80.4.465

To minimise the global burden of diabetes, the awareness of appropriate intervention methods for diabetes education and practice is essential. This project is the first international interprofessional education (IIPE) for the awareness of diabetes, w... Read More about A Scottish and Japanese experience of patient-centred diabetic care: descriptive study of interprofessional education on live webinar..

Development and evaluation of a novel interprofessional learning activity addressing the management of phenylketonuria. (2013)
Journal Article
DONALD, H., MCFADYEN, M.C.E. and BOYLE, S.P. 2013. Development and evaluation of a novel interprofessional learning activity addressing the management of phenylketonuria. Creative education [online], 4(3), pages 189-193. Available from: https://doi.org/10.4236/ce.2013.43028

This new initiative across the School of Pharmacy and Life Sciences at Robert Gordon University focuses around students from the Overseas Pharmacist's Assessment Programme (OSPAP), and third-year Nutrition and Dietetics students working in an interpr... Read More about Development and evaluation of a novel interprofessional learning activity addressing the management of phenylketonuria..

Differential regulation of CYP4Z1 mRNA in human breast cancer cell lines. (2008)
Presentation / Conference
WARASIHA, B., KNOTT, R. and MCFADYEN, M. 2008. Differential regulation of CYP4Z1 mRNA in human breast cancer cell lines. Presented at the 2008 National Cancer Research Institute cancer conference (NCRI 2008), 5-8 October 2008, Birmingham, UK.

CYP4Z1 is a novel cytochrome P450 enzyme that is preferentially expressed in normal breast and neoplastic breast tissue. This poster reported on the results of a study in which an in vitro cell model was used to define the mechanisms regulating CYP4Z... Read More about Differential regulation of CYP4Z1 mRNA in human breast cancer cell lines..

Cytochrome P450 mRNA profile in human breast cancer cell lines. (2008)
Thesis
WARASIHA, B. 2008. Cytochrome P450 mRNA profile in human breast cancer cell lines. Robert Gordon University, PhD thesis.

Cytochrome P450 enzymes (P450s) are involved in cancer development and treatment due to their roles in the oxidative metabolism of various compounds, both endogenous (e.g. oestrogen) and exogenous (e.g. tamoxifen). Intermediate P450 metabolites deriv... Read More about Cytochrome P450 mRNA profile in human breast cancer cell lines..

Cytochrome P450 CYP1B1 activity in renal cell carcinoma. (2004)
Journal Article
MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 2004. Cytochrome P450 CYP1B1 activity in renal cell carcinoma. British journal of cancer [online], 91, pages 966-971. Available from: https://doi.org/10.1038/sj.bjc.6602053

Renal cell carcinoma (RCC) is the most common malignancy of the kidney and has a poor prognosis due to its late presentation and resistance to current anticancer drugs. One mechanism of drug resistance, which is potentially amenable to therapeutic in... Read More about Cytochrome P450 CYP1B1 activity in renal cell carcinoma..

Anti-cancer drug interaction with cytochrome P450 CYP1B1. (2003)
Presentation / Conference
MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 2003. Anti-cancer drug interaction with cytochrome P450 CYP1B1. Presented at the 2003 British cancer research meeting (BCRM 2003), 2-5 July 2003, Bournemouth, UK.

One mechanism potentially amenable to chemotherapeutic intervention involves cytochrome P450 CYP1B1. Our research has established the concept of over-expression of individual forms of cytochrome P450 - in particular CYP1B1 - in a range of solid tumou... Read More about Anti-cancer drug interaction with cytochrome P450 CYP1B1..

Assessment of a putative oncogene ZNF217 in colorectal cancer by multiplex quantitative real-time PCR. (2002)
Presentation / Conference
ROONEY, P.H., BOONSONG, A., MCFADYEN, M., MCLEOD, H.L., CASSIDY, J. and MURRAY, G.I. 2002. Assessment of a putative oncogene ZNF217 in colorectal cancer by multiplex quantitative real-time PCR. Presented at the 184th Meeting of the Pathological Society of Great Britain and Ireland, 2-5 July 2002, Dublin, Ireland.

Detection of gene amplification is a process that is recognised as a means of identifying oncogenes. This presentation discusses a study in which the gene copy number of a putative oncogene (ZNF217) was assessed in 80 colon carcinomas by multiplex qu... Read More about Assessment of a putative oncogene ZNF217 in colorectal cancer by multiplex quantitative real-time PCR..

Metabolically active cytochrome P450 CYP1B1 in solid tumours: a novel target for chemotherapeutic intervention. (2002)
Presentation / Conference
MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 2002. Metabolically active cytochrome P450 CYP1B1 in solid tumours: a novel target for chemotherapeutic intervention. Presented at the 2002 British cancer research meeting (BCRM 2002), 30 June - 3 July 2002, Glasgow, UK.

Cytochrome P450 CYP1B1 is a member of a superfamily of haemoproteins that are central to the oxidative metabolism of a wide variety of endogenous and exogenous compounds. Several of these enzymes have an established role in the metabolic bio-transfor... Read More about Metabolically active cytochrome P450 CYP1B1 in solid tumours: a novel target for chemotherapeutic intervention..

Use of CYP1B1 inhibitors for treating cancer. (2001)
Patent
MURRAY, G.I., MELVIN, W.T. and MCFADYEN, M. 2001. Use of CYP1B1 inhibitors for treating cancer. International patent application PCT/GB2001/000548. International publication number WO/2001/058444 (WO 01/58444 A1), published 16.08.2001. Available from: https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2001058444

CYP1B1 proteins and their role in metabolising or inactivating anti-cancer drugs are disclosed, together with compositions for treating cancer comprising a substance capable of inhibiting CYP1B1 protein and an anti-cancer drug (e.g. docetaxel, paclit... Read More about Use of CYP1B1 inhibitors for treating cancer..

Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer. (2001)
Journal Article
MCFADYEN, M.C.E., CRUICKSHANK, M.E., MILLER, I.D., MCLEOD, H.L., MELVIN, W.T., HAITES, N.E., PARKIN, D. and MURRAY, G.I. 2001. Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer. British journal of cancer [online], 85(2), pages 242-246. Available from: https://doi.org/10.1054/bjoc.2001.1907

Ovarian cancer is the most frequent cause of death from gynaecological malignancies world wide. Little improvement has been made in the long-term outcome of this disease, with the 5-year survival of patients only 30%. This poor prognosis is due to th... Read More about Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer..

Cytochrome P450 CYP1B1: a novel mechanism of drug resistance. (2001)
Presentation / Conference
MCFADYEN, M.C.E., MELVIN, W.T. and MURRAY, G.I. 2001. Cytochrome P450 CYP1B1: a novel mechanism of drug resistance. Presented at the 2001 British cancer research meeting (BCRM 2001), 1-4 July 2001, Leeds, UK.

CYP1B1 is a member of the cytochrome P450 enzymes, which are central to the oxidative metabolism of a wide range of substrates, including endogenous compounds involved in cell signaling, environmental carcinogens and anti-cancer drugs. This presentat... Read More about Cytochrome P450 CYP1B1: a novel mechanism of drug resistance..