All Outputs (63)

Evaluation of new naphthalimides as potential anticancer agents against breast cancer MCF-7, pancreatic cancer BxPC-3 and colon cancer HCT-15 cell lines. (2015)
Journal Article
NORO, J., MACIEL, J., DUARTE, D., OLIVAL, A.C.D., BAPTISTA, C., SILVA, A.C.D., ALVES, M.J. and KONG THOO LIN, P. 2015. Evaluation of new naphthalimides as potential anticancer agents against breast cancer MCF-7, pancreatic cancer BxPC-3 and colon cancer HCT-15 cell lines. Organic chemistry: current research [online], 4(3), ID 1000144. Available from: https://doi.org/10.4172/2161-0401.1000144

New 1,8-naphthalimido derivatives with 2,3 and 4 carbon chains bearing a number of different functionalities were synthesized and tested against a panel of breast cancer MCF-7, colon cancer HCT-15 and pancreatic cancer BxPC-3 cell lines. Generally st... Read More about Evaluation of new naphthalimides as potential anticancer agents against breast cancer MCF-7, pancreatic cancer BxPC-3 and colon cancer HCT-15 cell lines..

Study of a novel bisnaphthalimidopropyl polyamine as electroactive material for perchlorate-selective potentiometric sensors. (2015)
Journal Article
GIL, R., AMORIM, C.G., CROMBIE, L., KONG THOO LIN, P., ARUJO, A. and da CONCEICAO MONTENEGRO, M. 2015. Study of a novel bisnaphthalimidopropyl polyamine as electroactive material for perchlorate-selective potentiometric sensors. Electroanalysis [online], 27(12), pages 2809-2819. Available from: https://doi.org/10.1002/elan.201500275

In this work, the new polyamine bisnaphthalimidopropyl-4,4'-diaminodiphenylmethane is proposed as a new ionophore for perchlorate potentiometric sensors. The optimal formulation for the membrane comprised of 12mmolkg-1 of the ionophore, and 68% (w/w)... Read More about Study of a novel bisnaphthalimidopropyl polyamine as electroactive material for perchlorate-selective potentiometric sensors..

Anti-pancreatic cancer potential of secalonic acid derivatives from endophytic fungi isolated from Ocimum basilicum. (2013)
Journal Article
SHOEB, M., HOQUE, M.E., KONG THOO LIN, P. and NAHAR, N. 2013. Anti-pancreatic cancer potential of secalonic acid derivatives from endophytic fungi isolated from Ocimum basilicum. Dhaka University journal of pharmaceutical sciences [online], 12(2), pages 91-95. Available from: https://doi.org/10.3329/dujps.v12i2.17624

The word endophyte means "in the plant" and refers to all microorganisms that live in the intercellular spaces of stems, petioles, roots and leaves of plants causing no apparent symptoms of disease. Seven endophytic fungi were isolated from the medic... Read More about Anti-pancreatic cancer potential of secalonic acid derivatives from endophytic fungi isolated from Ocimum basilicum..

Poly(allylamine) magnetomicelles for image guided drug delivery. (2013)
Journal Article
BARNETT, C. M., LEES, M. R., CURTIS, A. D. M., KONG THOO LIN, P., CHENG, W. P. and HOSKINS, C. 2013. Poly(allylamine) magnetomicelles for image guided drug delivery. Pharmaceutical nanotechnology [online], 1(3), pages 224-238. Available at: https://doi.org/10.2174/22117385113019990002

Polymeric micelles have received considerable interest for their use as drug delivery vehicles for hydrophobic drug solubilisation. Inorganic metallic nanoparticles have already been exploited clinically in diagnostics for their contrast ability, usi... Read More about Poly(allylamine) magnetomicelles for image guided drug delivery..

Anti-colon cancer activity of endophytic fungal strains from Terminalia chebula Rezt (2012)
Journal Article
SHOEB, M., KONG THOO LIN, P. and NAHAR, N. 2012. Anti-colon cancer activity of endophytic fungal strains from Terminalia chebula rezt. Bangladesh journal of pharmacology [online], 12(1), pages 47-49. Available from: https://doi.org/10.3329/bjp.v7i1.10507

Endophytic microorganisms are fungi or bacteria that live inside the healthy tissues of the host plants causing no apparent symptoms of diseases. Five endophytic fungal strains labeled as IR-1, IR-2, IR-4, IR-6 and IR-7 (identified as Penicillium thi... Read More about Anti-colon cancer activity of endophytic fungal strains from Terminalia chebula Rezt.

The use of nano polymeric self-assemblies based on novel amphiphilic polymers for oral hydrophobic drug delivery. (2011)
Journal Article
CLARE, H., KONG THOO LIN, P., TETLEY, L. and CHENG, W.P. 2012. The use of nano polymeric self-assemblies based on novel amphiphilic polymers for oral hydrophobic drug delivery. Pharmaceutical research [online], 29(3), pages 782-794. Available from: https://doi.org/10.1007/s11095-011-0602-7

Purpose: To investigate the use of nano self-assemblies formed by polyallylamine (PAA) modified with 5 or 10% mole fluorenylmethoxy carbonyl (Fmoc5/10), dimethylamino-1-naphthalenesulfonyl (Dansyl5/10) and 5% mole cholesteryl group (Ch5) for oral hyd... Read More about The use of nano polymeric self-assemblies based on novel amphiphilic polymers for oral hydrophobic drug delivery..

Nano self-assemblies based on cholate grafted poly-L-lysine enhanced the solubility of sterol-like drugs. (2011)
Journal Article
GU, J., CHENG, W.P., HOSKINS, C., KONG THOO LIN, P., ZHAO, L, ZHU, L., QU, X. and YANG, Z. 2011. Nano self-assemblies based on cholate grafted poly-L-lysine enhanced the solubility of sterol-like drugs. Journal of microencapsulation [online], 28(8): micro and nano carriers, pages 752-762. Available from: https://doi.org/10.3109/02652048.2011.615951

The physicochemical compatibility between amphiphilic polymers and hydrophobic drugs has been recognized as an important issue for improving the drug solubilisation in polymeric micelle formulations. In this work, poly-L-lysine (PLL) grafted by chola... Read More about Nano self-assemblies based on cholate grafted poly-L-lysine enhanced the solubility of sterol-like drugs..

In vitro and in vivo antimalarial activity assays of seeds from Balanites aegyptiaca: compounds of the extract show growth inhibition and activity against Plasmodial aminopeptidase. (2011)
Journal Article
KUSCH, P., DEININGER, S., SPECHT, S., MANIAKO, R., HAUBRICH, S., POMMERENING, T., KONG THOO LIN, P., HOERAUF, A. and KAISER, A. 2011. In vitro and in vivo antimalarial activity assays of seeds from Balanites aegyptiaca: compounds of the extract show growth inhibition and activity against Plasmodial aminopeptidase. Journal of parasitology research [online], 2011, article ID 368692. Available from: https://doi.org/10.1155/2011/368692

Balanites aegyptiaca (Balanitaceae) is a widely grown desert plant with multiuse potential. In the present paper, a crude extract from B. aegyptiaca seeds equivalent to a ratio of 1:2000 seeds to the extract was screened for antiplasmodial activity.... Read More about In vitro and in vivo antimalarial activity assays of seeds from Balanites aegyptiaca: compounds of the extract show growth inhibition and activity against Plasmodial aminopeptidase..

In vitro and in vivo anticancer activity of a novel nano-sized formulation based on self-assembling polymers against pancreatic cancer. (2010)
Journal Article
HOSKINS, C., OUAISSI, M., LIMA, S.C., CHENG, W.P., LOUREIRIO, I., MAS, E., LOMBARDO, D., CORDEIRO-DA-SILVA, A., OUAISSI, A. and KONG THOO LIN, P. 2010. In vitro and in vivo anticancer activity of a novel nano-sized formulation based on self-assembling polymers against pancreatic cancer. Pharmaceutical research [online], 27(12), pages 2694-2703. Available from: https://doi.org/10.1007/s11095-010-0268-6

Purpose: To evaluate the in vitro and in vivo pancreatic anticancer activity of a nano-sized formulation based on novel polyallylamine grafted with 5% mole cholesteryl pendant groups (CH5-PAA). Methods: Insoluble novel anticancer drug, Bisnaphthalimi... Read More about In vitro and in vivo anticancer activity of a novel nano-sized formulation based on self-assembling polymers against pancreatic cancer..

The characterisation and identification of body fluid proteins for forensic purposes. (2010)
Thesis
VINCINI, L. 2010. The characterisation and identification of body fluid proteins for forensic purposes. Robert Gordon University, PhD thesis.

Advances in DNA technology have led to the extremely sensitive and rapid analysis methods used in forensic science. It can often be crucial to a criminal case to unequivocally identify the body fluid source of DNA. This is of particular importance in... Read More about The characterisation and identification of body fluid proteins for forensic purposes..

Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system. (2010)
Thesis
BARRON, G. 2010. Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system. Robert Gordon University, PhD thesis.

The synthesis and characterisation of novel bisnaphthalimidopropyl polyamine (BNIPP) derivatives has gained pace over the last couple of years, as they have enhanced aqueous solubility without loss of biological activity in contrast to parent bisnaph... Read More about Novel bisnaphthalimidopropyl polyamine derivatives: their mode of action in a breast cancer cell system..

The use of novel poly(allylamine) based amphiphilic polymers for drug delivery. (2010)
Thesis
HOSKINS, C. 2010. The use of novel poly(allylamine) based amphiphilic polymers for drug delivery. Robert Gordon University, PhD thesis.

Fourteen novel comb shaped amphiphilic polymers were successfully synthesised to determine the effect of polymer architecture on the potential of these amphiphilic polymers for hydrophobic drug delivery. Polyallylamine (PAA) was grafted with four dif... Read More about The use of novel poly(allylamine) based amphiphilic polymers for drug delivery..

The effect of CLAs on the expression of PKC isoforms and cell viability in breast cancer cell lines. (2008)
Thesis
CRABB-WYKE, R. 2008. The effect of CLAs on the expression of PKC isoforms and cell viability in breast cancer cell lines. Robert Gordon University, MPhil thesis.

Breast tumours make up 15% of the total cancer burden in the UK and around 8% of the total number of cancer related deaths. Protein kinase C (PKC) isoforms have been shown to be strongly modulated in many androgen sensitive tumour cell lines. Increas... Read More about The effect of CLAs on the expression of PKC isoforms and cell viability in breast cancer cell lines..

Bioactivity of the extracts and isolation of lignans and a sesquiterpene from the aerial parts of Centaurea pamphylica (Asteraceae). (2007)
Journal Article
SHOEB, M., MACMANUS, S.M., KONG THOO LIN, P., CELIK, S., JASPARS, M., NAHR, L. and SARKER, S.D. 2007. Bioactivity of the extracts and isolation of lignans and a sesquiterpene from the aerial parts of Centaurea pamphylica (Asteraceae). DARU journal of pharmaceutical sciences [online], 15(3), pages 118-122. Available from: http://daru.tums.ac.ir/index.php/daru/article/view/315/315

Centaurea pamphylica Boiss. & Heldr. (Family: Asteraceae), commonly known as 'pamphylia daisy', is a Turkish endemic species of the genus Centaurea that comprises ca. 500 species, many of which have been used as traditional medicines. The n-hexane, d... Read More about Bioactivity of the extracts and isolation of lignans and a sesquiterpene from the aerial parts of Centaurea pamphylica (Asteraceae)..

Bioactivity of two Turkish endemic centaurea species, and their major constituents. (2007)
Journal Article
SHOEB, M., MACMANUS, S.M., JASPARS, M., KONG THOO LIN, P., NAHAR, L., CELIK, S. and SARKER, S.D. 2007. Bioactivity of two Turkish endemic centaurea species, and their major constituents. Revista Brasileira de Farmacognosia/Brazilian journal of pharmacognosy [online], 17(2), pages 155-159. Available from: https://doi.org/10.1590/S0102-695X2007000200003

The antioxidant activity, general toxicity and cytotoxicity of the methanol extracts of Centaurea urvillei subs, armata and C. mucronifera have been assessed, respectively, by the DPPH assay, the brine shrimp lethality and the MTT cytotoxicity assays... Read More about Bioactivity of two Turkish endemic centaurea species, and their major constituents..

Cytotoxic compounds from the genus Centaurea. (2005)
Thesis
SHOEB, M. 2005. Cytotoxic compounds from the genus Centaurea. Robert Gordon University, PhD thesis.

This thesis, which is divided into four chapters, represents an account on the isolation, identification and the assessment of bioactivity of cytotoxic compounds from the genus Centaurea (Family: Asteraceae alto Compositae), a large genus of about 50... Read More about Cytotoxic compounds from the genus Centaurea..

Two oxazane macrocycles. (2004)
Journal Article
COX, P.J. and KONG THOO LIN, P. 2004. Two oxazane macrocycles. Acta crystallographica section C: structural chemistry [online], 60(5), pages o321-o324. Available from: https://doi.org/10.1107/S0108270104006687

The 20-membered ring in 1,7,11,17-tetraoxa-2,6,12,16-tetraazacycloeicosane tetrahydrochloride, C12H32N4O44+·4Cl-, adopts an endo conformation, while the 18-membered ring in 1,6,10,15-tetraoxa-2,5,11,14-tetraazacyclooctadecane tetrahydrochloride, C10H... Read More about Two oxazane macrocycles..

Morphological changes in MCF-7 human breast cancer cells in response to Bis-Naphthalimidopropylspermidine-treatment. (2002)
Journal Article
PAVLOV, V., RODILLA, V. and KONG THOO LIN, P. 2002. Morphological changes in MCF-7 human breast cancer cells in response to Bis-Naphthalimidopropylspermidine-treatment. Biotechnology and biotechnological equipment [online], 16(1), pages 118-123. Available from: https://doi.org/10.1080/13102818.2002.10819165

The effects of bis-naphthalimidopropylspermidine (BNIPSpd), a representative of a novel class of polyamine derivatives with antiproliferative properties on the morphology of MCF-7 human breast cancer cells were studied. BNIPSpd was shown to cause cyt... Read More about Morphological changes in MCF-7 human breast cancer cells in response to Bis-Naphthalimidopropylspermidine-treatment..

Rerefinement of (μ-1,7,11,17-tetraoxa-2,6,12,16-tetraazacycloeicosane-κ4N1,N17:N7,N11)bis[dichlorozinc(II)]. [Dataset] (2002)
Data
KUKSA, V.A., WARDELL, S.M.S.V. , KONG THOO LIN, P. and HOWIE, R.A. 2002. Rerefinement of ([mu]-1,7,11,17-tetraoxa-2,6,12,16-tetra­aza­cyclo­ei­cosane-[kappa]4N1,N17:N7,N11)­bis­[di­chlorozinc(II)]. [Dataset]. Acta crystallographica section E: crystallographic communications [online], 58(2), pages m68-m69. Available from: https://doi.org/10.1107/S1600536802001654

This rerefinement of the title compound, [Zn2Cl4(C12H28­N4O4)], based on the original intensity data, differs from the original only in the exchange of the NH and O moieties of the oxa­aza-macrocycle, resulting in a dramatic improvement in the R fact... Read More about Rerefinement of (μ-1,7,11,17-tetraoxa-2,6,12,16-tetraazacycloeicosane-κ4N1,N17:N7,N11)bis[dichlorozinc(II)]. [Dataset].

6-(3,5-Di-O-acetyl-β-D-2-deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7(6H)-one. [Dataset] (1995)
Data
VAN MEERVELT, L., KONG THOO LIN, P. and BROWN, D.M. 1995. 6-(3,5-Di-O-acetyl-β-D-2-deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7(6H)-one. [Dataset] Acta crystallographica section C: crystal structure communications [online], 51(7), pages 1347-1350. Available from: https://doi.org/10.1107/s0108270195000096

The title compound, C15H19N3O7 (P), crystallizes with two molecules in the asymmetric unit which differ in sugar and oxazino ring puckering; both occur as the imino tautomer and form P;P wobble base pairs. The supporting information for the published... Read More about 6-(3,5-Di-O-acetyl-β-D-2-deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7(6H)-one. [Dataset].