All Outputs (62)

The potential use of plant natural products and plant extracts with antioxidant properties for the prevention/treatment of neurodegenerative diseases: in vitro, in vivo and clinical trials. (2018)
Journal Article
POHL, F. and KONG THOO LIN, P. 2018. The potential use of plant natural products and plant extracts with antioxidant properties for the prevention/treatment of neurodegenerative diseases: in vitro, in vivo and clinical trials. Molecules [online], 23(12), article ID 3283. Available from: https://doi.org/10.3390/molecules23123283

Neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease and Huntington's disease, present a major health issue and financial burden for health care systems around the world. The impact of these diseases will further increase o... Read More about The potential use of plant natural products and plant extracts with antioxidant properties for the prevention/treatment of neurodegenerative diseases: in vitro, in vivo and clinical trials..

Sustainable treatment of oil contaminated waste: oil-based mud (OBM) drill cuttings and soil. (2018)
Thesis
NWINEE, S.A. 2018. Sustainable treatment of oil contaminated waste: oil-based mud (OBM) drill cuttings and soil. Robert Gordon University, PhD thesis.

Environmental pollution from oilfield drilling waste poses potential hazards which can lead to ecological imbalance. The predominant pollutant from oilfield waste is petroleum hydrocarbons. Some effects of petroleum hydrocarbon contamination in soil... Read More about Sustainable treatment of oil contaminated waste: oil-based mud (OBM) drill cuttings and soil..

Determination of sinapine in rapeseed pomace extract: its antioxidant and acetylcholinesterase inhibition properties. (2018)
Journal Article
YATES, K., POHL, F., BUSCH, M., MOZER, A., WATTERS, L., SHIRYAEV, A. and KONG THOO LIN, P. 2019. Determination of sinapine in rapeseed pomace extract: its antioxidant and acetylcholinesterase inhibition properties. Food chemistry [online], 276, pages 768-775. Available from: https://doi.org/10.1016/j.foodchem.2018.10.045

Sinapine is the main secondary metabolite present in rapeseed pomace (RSP) with its concentration being dependent on rapeseed processing, growing conditions, extraction parameters and the country of origin. Here we report, the concentration of sinapi... Read More about Determination of sinapine in rapeseed pomace extract: its antioxidant and acetylcholinesterase inhibition properties..

A novel PAA derivative with enhanced drug efficacy in pancreatic cancer cell lines. (2018)
Journal Article
ALSURAIFI, A., KONG THOO LIN, P., CURTIS, A., LAMPROU, D.A. and HOSKINS, C. 2018. A novel PAA derivative with enhanced drug efficacy in pancreatic cancer cell lines. Pharmaceuticals [online], 11(4), article ID 91. Available from: https://doi.org/10.3390/ph11040091

Nanoparticles have been shown to be effective drug carriers in cancer therapy. Pancreatic cancer forms dense tumours which are often resistant to drug molecules. In order to overcome such multidrug resistance, new drug entities, novel delivery system... Read More about A novel PAA derivative with enhanced drug efficacy in pancreatic cancer cell lines..

Caspase-independence and characterization of bisnaphthalimidopropyl spermidine induced cytotoxicity in HL60 cells. (2018)
Journal Article
BESTWICK, C., MILNE, L., DANCE, A.-M., COCHENNEC, G., CRUICKSHANK, G., ALLAIN, E., CONSTABLE, L., DUTHIE, S.J. and KONG THOO LIN, P. 2018. Caspase-independence and characterization of bisnaphthalimidopropyl spermidine induced cytotoxicity in HL60 cells. Toxicology in vitro [online], 52, pages 342-350. Available from: https://doi.org/10.1016/j.tiv.2018.06.023

Bisnaphthalimides are DNA intercalators of potential use as chemotherapeutics but for which the range of mechanism of action is only gradually being elucidated. Using human promyelocytic HL-60 cells, we extend characterization of the cytotoxicity of... Read More about Caspase-independence and characterization of bisnaphthalimidopropyl spermidine induced cytotoxicity in HL60 cells..

Targeting histone deacetylase (HDACs) enzymes with novel bisnaphthalimidopropyl derivatives (BNIPs) as alternative breast cancer therapies. (2018)
Thesis
KOPSIDA, M. 2018. Targeting histone deacetylase (HDACs) enzymes with novel bisnaphthalimidopropyl derivatives (BNIPs) as alternative breast cancer therapies. Robert Gordon University, PhD thesis.

Breast cancer is the most commonly occurring cancer in women, with incidence rates approaching 1.38 million cases per year worldwide. Over the last few decades, there have been numerous attempts to develop, synthesise and advance into the clinic nove... Read More about Targeting histone deacetylase (HDACs) enzymes with novel bisnaphthalimidopropyl derivatives (BNIPs) as alternative breast cancer therapies..

Inhibitors of trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease. (2018)
Journal Article
GASPAR, L., CORON, R.P., KONG THOO LIN, P., COSTA, D.M., PERES-CABEZAS, B., TAVARES, J., ROURA-FERRER, M., RAMOS, I., RONIN, C., MAJOR, L.L., CIESIELSKI, F., PEMBERTON, I.K., MACDOUGALL, J., CIAPETTI, P., SMITH, T.K. and CORDEIRO-DA-SILVA, A. 2018. Inhibitors of trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease. PLoS neglected tropical diseases [online], 12(1), article number e0006180. Available from: https://doi.org/10.1371/journal.pntd.0006180

Chagas disease remains one of the most neglected diseases in the world despite being the most important parasitic disease in Latin America. The characteristic chronic manifestation of chagasic cardiomyopathy is the region's leading cause of heart-rel... Read More about Inhibitors of trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease..

Novel vanillin derivatives: synthesis, anti-oxidant, DNA and cellular protection properties. (2017)
Journal Article
SCIPIONI, M., KAY, G., MEGSON, I. and KONG THOO LIN, P. 2017. Novel vanillin derivatives: synthesis, anti-oxidant, DNA and cellular protection properties. European journal of medicinal chemistry [online], 143, pages 745-754. Available from: https://doi.org/10.1016/j.ejmech.2017.11.072

Antioxidants have been the subject of intense research interest mainly due to their beneficial properties associated with human health and wellbeing. Phenolic molecules, such as naturally occurring Resveratrol and Vanillin, are well known for their a... Read More about Novel vanillin derivatives: synthesis, anti-oxidant, DNA and cellular protection properties..

Thermally triggered theranostics for pancreatic cancer therapy. (2017)
Journal Article
MALEKIGORJI, M., ALFAHAD, M., KONG THOO LIN, P., JONES, S., CURTIS, A. and HOSKINS, C. 2017. Thermally triggered theranostics for pancreatic cancer therapy. Nanoscale [online], 9(34), pages 12735-12745. Available from: https://doi.org/10.1039/c7nr02751f

Hybrid iron oxide-gold nanoparticles (HNPs) are capable of drug binding onto their surface with a triggered release at elevated temperatures. The iron oxide core allows for diagnostic imaging whilst heating of the gold shell upon laser irradiation re... Read More about Thermally triggered theranostics for pancreatic cancer therapy..

Revalorisation of rapeseed pomace extracts: an in vitro study into its anti-oxidant and DNA protective properties. (2017)
Journal Article
POHL, F., GOUA, M., BERMANO, G., RUSSELL, W.R., SCOBBIE, L., MACIEL, P. and KONG THOO LIN, P. 2018. Revalorisation of rapeseed pomace extracts: an in vitro study into its anti-oxidant and DNA protective properties. Food chemistry [online], 239, pages 323-332. Available from: https://doi.org/10.1016/j.foodchem.2017.06.129

Rapeseed pomace (RSP) is a waste product obtained after edible oil production from Brassica napus. Analysis of ubiquitous secondary metabolites in RSP samples (two breeds, harvested in 2012/2014 respectively from North East of Scotland) and their eth... Read More about Revalorisation of rapeseed pomace extracts: an in vitro study into its anti-oxidant and DNA protective properties..

Dual-laboratory validation of a method for the determination of fructans in infant formula and adult nutritionals. (2017)
Journal Article
BRUNT, K., SANDERS, P., SPICHTIG, V., ERNSTE-NOTA, V., SAWICKA, P., IWANOFF, K., VAN SOEST, J., KONG THOO LIN, P. and SEAN, A. 2017. Dual-laboratory validation of a method for the determination of fructans in infant formula and adult nutritionals. Journal of AOAC international [online], 100(3), pages 753-767. Available from: https://doi.org/10.5740/jaoacint.17-0007

Until recently, only two AOAC Official MethodsSM have been available for the analysis of fructans: Method 997.08 and Method 999.03. Both are based on the analysis of the fructan component monosaccharides (glucose and fructose) after hydrolysis. The t... Read More about Dual-laboratory validation of a method for the determination of fructans in infant formula and adult nutritionals..

Novel bisnaphthalimidopropyl (BNIPs) derivatives as anticancer compounds targeting DNA in human breast cancer cells. (2016)
Journal Article
KOPSIDA, M., BARRON, G.A. BERMANO, G., KONG THOO LIN, P. and GOUA, M. 2016. Novel bisnaphthalimidopropyl (BNIPs) derivatives as anticancer compounds targeting DNA in human breast cancer cells. Organic and biomolecular chemistry [online], 14(41), pages 9780-9789. Available from: https://doi.org/10.1039/C6OB01850E

Bisnaphthalimidopropyl (BNIP) derivatives are a family of compounds that exert anti-cancer activities in vitro and, according to previous studies, variations in the linker sequence have increased their DNA binding and cytotoxic activities. By modifyi... Read More about Novel bisnaphthalimidopropyl (BNIPs) derivatives as anticancer compounds targeting DNA in human breast cancer cells..

Thermally triggered theranostics for pancreatic cancer. (2016)
Presentation / Conference Contribution
MALEKIGORJI, M., KONG THOO LIN, P., LEES, M., GUEORGUIEVA, M., CURTIS, A., & HOSKINS, C. 2016. Thermally triggered theranostics for pancreatic cancer. Presented at 24th biennial European Association for Cancer Research congress 2016 (EACR24), 9-12 July 2016, Manchester, UK.

Background: Pancreatic cancer is the 4th most aggressive cancer in the western world with less than 34% of patients surviving past 5 years. Lack of specific symptoms results in delayed diagnosis. Theranostics are new platforms, which offer simultaneo... Read More about Thermally triggered theranostics for pancreatic cancer..

Activity of bisnaphthalimidopropyl derivatives against trypanosoma brucei. (2016)
Journal Article
GRACA, N.A.G., GASPAR, L, COSTA, D.M., LOUREIRO, I., KONG THOO LIN, P., RAMOS, I., ROURA, M., PRUVOST, A., PEMBERTON, I.K., LOUKIL, H., MACDOUGALL, J., TAVARES, J. and CORDEIRO-DA-SILVA, A. 2016. Activity of bisnaphthalimidopropyl derivatives against trypanosoma brucei. Antimicrobial agents and chemotherapy [online], 60(4), pages 2532-2536. Available from: https://doi.org/10.1128/AAC.02490-15

Current treatments for African trypanosomiasis are either toxic, costly, difficult to administer, or prone to elicit resistance. This study evaluated the activity of bisnaphthalimidopropyl (BNIP) derivatives against Trypanosoma brucei. BNIPDiaminobut... Read More about Activity of bisnaphthalimidopropyl derivatives against trypanosoma brucei..

Study into the polyphenol content and antioxidant activity of rapeseed pomace extracts. (2016)
Presentation / Conference Contribution
POHL, F., GOUA, M., BERMANO, G., RUSSELL, W.R., MACIEL, P. and KONG THOO LIN, P. 2016. Study into the polyphenol content and antioxidant activity of rapeseed pomace extracts. Presented at 2016 Nutrition Society's Scottish section meeting: phytochemicals and health: new perspectives on plant based nutrition, 21-22 March 2016, Edinburgh, UK.

Rapeseed pomace (RSP) is a waste product obtained after edible oil production from Brassica napus. This study aimed to determine the polyphenol content, radical scavenging activity, ferric iron reducing antioxidant power and the oxygen-radical absorb... Read More about Study into the polyphenol content and antioxidant activity of rapeseed pomace extracts..

Exploiting the antiparasitic activity of naphthalimides derivatives. (2016)
Journal Article
CRISTO, G., GASPAR, L., NORO, J., BAPTISTA, C., KONG THOO LIN, P., ALVES, M.J. and CORDEIRO-DA-SILVA, A. 2016. Exploiting the antiparasitic activity of naphthalimides derivatives. International journal of chemistry and pharmaceutical sciences [online], 4(1), pages 19-23. Available from: http://www.pharmaresearchlibrary.com/wp-content/uploads/2016/06/IJCPS2793.pdf

A set of 1,8-naphtalimides derivatives were synthesized and tested against three protozoans that cause important human diseases: Leishmania infantum, Trypanosomabrucei and Trypanosoma cruzi. Additionally, toxicity was determined by growth inhibition... Read More about Exploiting the antiparasitic activity of naphthalimides derivatives..

Development and validation of HPLC method with fluorometric detection for quantification of bisnaphthalimidopropyldiaminooctane in animal tissues following administration in polymeric nanoparticles. (2015)
Journal Article
SEGUNDO, M.A., ABREU, V.L.R.G., OSORIO, M.V., NOGUEIRA, S., KONG THOO LIN, P., CORDEIRO-DA-SILVA, A. and LIMA, S.A.C. 2016. Development and validation of HPLC method with fluorometric detection for quantification of bisnaphthalimidopropyldiaminooctane in animal tissues following administration in polymeric nanoparticles. Journal of pharmaceutical and biomedical analysis [online], 120, pages 290-296. Available from: https://doi.org/10.1016/j.jpba.2015.12.033

A simple, sensitive and specific high-performance liquid chromatography method for the quantification of bisnaphthalimidopropyldiaminooctane (BNIPDaoct), a potent anti-Leishmania compound, incorporated into poly(d,l-lactide-co-glycolic acid) (PLGA) n... Read More about Development and validation of HPLC method with fluorometric detection for quantification of bisnaphthalimidopropyldiaminooctane in animal tissues following administration in polymeric nanoparticles..

Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression. (2015)
Journal Article
BARRON, G.A., GOUA, M., KURAOKA, I., BERMANO, G., IWAI, S. and KONG THOO LIN, P. 2015. Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression. Chemico-biological interactions [online], 242, pages 307-315. Available from: https://doi.org/10.1016/j.cbi.2015.10.017

Bisnaphthalimidopropyl diaminodicyclohexylmethane (BNIPDaCHM) bisintercalates to DNA and is a potential anti-cancer therapeutic. In an attempt to elucidate the mechanism(s) underlying the potential of BNIPDaCHM; earlier work was extended to investiga... Read More about Bisnaphthalimidopropyl diaminodicyclohexylmethane induces DNA damage and repair instability in triple negative breast cancer cells via p21 expression..

Evaluation of new naphthalimides as potential anticancer agents against breast cancer MCF-7, pancreatic cancer BxPC-3 and colon cancer HCT-15 cell lines. (2015)
Journal Article
NORO, J., MACIEL, J., DUARTE, D., OLIVAL, A.C.D., BAPTISTA, C., SILVA, A.C.D., ALVES, M.J. and KONG THOO LIN, P. 2015. Evaluation of new naphthalimides as potential anticancer agents against breast cancer MCF-7, pancreatic cancer BxPC-3 and colon cancer HCT-15 cell lines. Organic chemistry: current research [online], 4(3), ID 1000144. Available from: https://doi.org/10.4172/2161-0401.1000144

New 1,8-naphthalimido derivatives with 2,3 and 4 carbon chains bearing a number of different functionalities were synthesized and tested against a panel of breast cancer MCF-7, colon cancer HCT-15 and pancreatic cancer BxPC-3 cell lines. Generally st... Read More about Evaluation of new naphthalimides as potential anticancer agents against breast cancer MCF-7, pancreatic cancer BxPC-3 and colon cancer HCT-15 cell lines..

Study of a novel bisnaphthalimidopropyl polyamine as electroactive material for perchlorate-selective potentiometric sensors. (2015)
Journal Article
GIL, R., AMORIM, C.G., CROMBIE, L., KONG THOO LIN, P., ARUJO, A. and da CONCEICAO MONTENEGRO, M. 2015. Study of a novel bisnaphthalimidopropyl polyamine as electroactive material for perchlorate-selective potentiometric sensors. Electroanalysis [online], 27(12), pages 2809-2819. Available from: https://doi.org/10.1002/elan.201500275

In this work, the new polyamine bisnaphthalimidopropyl-4,4'-diaminodiphenylmethane is proposed as a new ionophore for perchlorate potentiometric sensors. The optimal formulation for the membrane comprised of 12mmolkg-1 of the ionophore, and 68% (w/w)... Read More about Study of a novel bisnaphthalimidopropyl polyamine as electroactive material for perchlorate-selective potentiometric sensors..