Projects (13)

Development of Fast Field MRI as a novel method to monitor liver regeneration in non-alcoholic fatty liver disease (NAFLD) Mar 1, 2018 - Feb 28, 2019

sFRPs as a novel modulator of diastolic heart failure Oct 1, 2017 - Dec 31, 2021
Following a heart attack, or because of persistently high blood pressure the heart is damaged and has to work harder to circulate blood around the body. This condition is known as heart failure. In the UK alone, 500,000 people have heart failure re... Read More about sFRPs as a novel modulator of diastolic heart failure.

The in vitro effect of natural products and anti-cancer agents: targeting the efflux transporter ABCG2 Jul 1, 2017 - Dec 31, 2019
Medicinal use of natural products, such as, extracts from plants have existed for many years particularly in China and are now widely available around the world. Several different types of cancer including breast cancer are becoming insensitive and r... Read More about The in vitro effect of natural products and anti-cancer agents: targeting the efflux transporter ABCG2.

Defining the emerging roles of GPR55 Oct 1, 2019 - Feb 4, 2023
The G-protein coupled receptor (GPCR) superfamily play crucial roles in cell communication. Given their involvement in neurological disorders, inflammatory and metabolic diseases, diabetes and cardiac dysfunction they represent the largest and most s... Read More about Defining the emerging roles of GPR55.

Extracting added value from the Seaweed Industry - a search for novel anti-obesity agents Oct 1, 2018 - Dec 31, 2022
Seaweed farming is a growing industry in the UK, with the majority of the biomass being used for the extraction of high yield products such as aliginates, or for use as biofuels.

However, a significant amount of the biomass remains un-used and t... Read More about Extracting added value from the Seaweed Industry - a search for novel anti-obesity agents.

Exploring the relationship between age-related zinc deficiency and obesity and the extent of myocardial damage following acute myocardial infarction Oct 1, 2018 - Jan 1, 2021
Zinc (Zn 2+) is a metal found in trace amounts in the body and plays an essential role in maintaining the healthy functioning of most organs, including the heart. The body does not store zinc in large quantities and so replenishment of Zn 2+ through... Read More about Exploring the relationship between age-related zinc deficiency and obesity and the extent of myocardial damage following acute myocardial infarction.

Protective effects of cannabidiol in doxorubicin induced cardiotoxicity Oct 1, 2018 - Dec 31, 2019

Multi-targets drug against Alzheimer (AD) disease: Mechanistic studies of drug action through amyloid and associated signalling pathways. Sep 1, 2020 - Dec 31, 2022

The aim of this project is to synthesise a small discrete library of novel compounds based on our lead compound, by applying the methodology developed in our laboratory, and to study the mechanism of action of active one and confirm the multi targe... Read More about Multi-targets drug against Alzheimer (AD) disease: Mechanistic studies of drug action through amyloid and associated signalling pathways..

Bioactivity of compounds derived from Amaryllicaea (Daffodil) Feb 1, 2021 - Jul 31, 2022
Heart Failure (HF) is a long-term complication of cardiovascular (high blood pressure and heart attack) and cardiovascular-related (obesity and metabolic syndrome) disorders and of drug-induced cardiotoxicity. HF is characterised by thickening (hype... Read More about Bioactivity of compounds derived from Amaryllicaea (Daffodil).

Valorisation of Biomass from the Daffodil Growing Industry Oct 1, 2021 - Sep 30, 2025
The UK is a world leader in the commercial production of daffodils, with Scottish-based farmers’ cooperative Grampian Growers Ltd (GG) at the forefront of the industry. The majority of daffodil biomass produced by GG is used for bulb and flower expo... Read More about Valorisation of Biomass from the Daffodil Growing Industry.

Development and characterisation of novel polymer-drug conjugates for the treatment of Alzheimer’s disease Sep 1, 2022 - Aug 31, 2024
Using new polymer-drug compounds to improve the ability to deliver anti-Alzheimer drugs in the body.

Cannabidiol and CBD oil for prevention of cardiac dysfunction Mar 9, 2023 - Dec 19, 2024
Cannabidiol (CBD) has cardioprotective properties against the outcome of myocardial ischaemia and reperfusion. CBD oil, which contains not only cannabidiol but a host of biologically active molecules that may also offer some benefits to cardiac heal... Read More about Cannabidiol and CBD oil for prevention of cardiac dysfunction.

Multitargets drug for Sepsis: Mechanistic studies of drug action through mitigating infection and inflammatory responses associated with sepsis. Oct 1, 2023 - Sep 30, 2025
Sepsis is a life-threatening clinical condition caused by an overreacting immune system fighting an infection. It is often treated with broad-spectrum antibiotics together with anti-inflammatory drugs. However, due to the heterogeneous nature of the... Read More about Multitargets drug for Sepsis: Mechanistic studies of drug action through mitigating infection and inflammatory responses associated with sepsis..